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* An enzyme that breaks down collagen fibers and hyaluronic acid in the skin
* Read TIA’s article about Phytessence Wakame that includes a good summary of Hyaluronidase
Although Hyaluronidase is a pesky enzyme that breaks down collagen in the skin. It destroys the natural hyaluronic acid created in the body, therefore disabling it from binding collagen and elastin molecules. This prevents the formation of new collagen and elastin and causes premature wrinkling and sagging. Levels of Hyaluronidase are increased by free radicals (Souce).
However, new uses have been found for Hyaluronidase. Although fillers such as Juvederm, Elevess, Perlane and Prevelle have done wonders for the elimination of wrinkle appearance, overfilling is a common problem and leads to an unnatural appearance of the skin. Hyaluronidase is now being used as a problem solver rather than a problem causer. It's natural tendency to break down Hyaluronic acid is now being harnessed to lessen the effects of overfilling. When injected, it breaks down the Hyaluronic acid filler in the skin, while not dissolving natural tissue, according to RealSelf.com. Rather than waiting for the plumping hyaluronic acid to be absorbed into the body naturally, Hyaluronidase speeds up the process.
A study published in the medical journal, Dermatology, found that within 4 - 7 days of an injection of Hyaluronidase into a previously filled site, 80% of the filler gel had disappeared, while on a control site, 90% of the gel remained.
Safety Measures/Side Effects:
There are no negative side effects associated with the use of Hyaluronidase as a filler disintegration ingredient at this time.