My Cart 0 $0.00

You have no items in your shopping cart.

Problems Adding to Cart? Click here for assistance.

Palmitoyl Pentapeptide-4

* Molecules that link amino acids

* Also known as Matrixyl and Palmitoyl Pentapeptide-3

* Please read TIA's articles on What Is It: Pentapeptides and the Latest Botox in a Jar Potion and What Is It: Matrixyl

Functions:

Palmitoyl Pentapeptide-4 was developed by the corporations Sederma SA and Proctor & Gamble and originally named Palmitoyl Pentapeptide-3, but later renamed to Palmitoyl Pentapeptide-4 to reflect a correction in the data on its molecular structure, according to research. It is also included in many commercial formulas under the trademark of Matrixyl.

Palmitoyl Pentapeptide-4 is a pentapeptide, synethsized chain protein created by linking five amino acid peptides. This chain creates a response in the dermis of the skin that stimulates collagen and elastin fibroblasts, developing fibronectin (FN) and glycosaminoglycans (GAG), according to research. Palmitoyl Pentapeptide-4 is a small molecule that penetrates the skin easily and is structurally similar to the precursor of collagen type I. It is thought that pentapeptides can communicate with a cell and program it to do specific things, including repair work.

Palmitoyl Pentapeptide-4 is considered to be as effective against wrinkles as retinol, but less irritating. According to SmartSkinCare.com, "One study found that Palmitoyl Pentapeptide-4 was as effective as retinol in repairing sun-damaged skin but was devoid of side-effects. Most other studies showed at least some improvement in various objective and subjective measures of wrinkles."

Independent in vitro studies (unlike most studies available on Palmitoyl Pentapeptide-4, which have been done by P&G, originators of Matrixyl) demonstrated an increase in synthesis of Collagen I by 212%, Collagen IV by 100 to 327% and Hyaluronic Acid by 267%. Collagen I is predominant among the 19 forms of collagen found in the human body; therefore increasing production of Collagen I has a very dramatic effect on rebuilding the skin. Six month in vivo studies showed mean wrinkle depth was reduced by 17%, surface area containing deep wrinkles was reduced by 68%, surface area containing moderate wrinkles was reduced by 51% and skin roughness by 16% (Source).

Safety Measures/Side Effects:

The EWG gives Palmitoyl Pentapeptide-4 a zero rating based on  100% data gap. No studies were found that noted harmful side effects or safety warnings regarding its use. However, independent studies of this ingredient are rare.

Recommended Products with Palmitoyl Pentapeptide-4:

Medik8 Pretox Infin8 2nd Generation Triple Peptide Gel ($135 in the shop); Michael Todd Damascus Rose Enriched Anti-Wrinkle Cream ($89 in the shop); Juice Beauty Green Apple Firming Body Moisturizer ($18 in the shop); Medik8 Firewall ($145 in the shop)

Discover with Marta

Discover With Marta

Members get to find out what anti-agers really work.

Join Today

Truth In Aging Videos

Helpful how-tos from Marta and friends.

Watch Now

Becky

Meet Our Contributors

The TIA community consists of our trusted reviewers.

Meet Them

jennifer aniston

Be Inspired

Inspiring thoughts and women who are aging gracefully.

Read More

Please wait...

Continue shopping or View cart & checkout
Continue shopping or View cart & checkout
  Loading...