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Argireline

*Also known as acetyl hexapeptide-3 or AH-3 *Read TIA's article Will Argireline Make My Skin Sag? *Read TIA's article Argireline: What It Does and How It Works *Read TIA's article Pentapeptides and the Latest 'Botox in a Jar' Potion

Argireline is a synthetic hexapeptide consisting of the amino acids arginine, Glutamine, methionine and acetylated glutamic acid. It was formulated in an attempt to visibly reduce wrinkles that occur around the forehead and eyes (PubMed, International Journal of Cosmetic Sceiences). Argireline has been described as “Botox in a jar” due to it being a substrate of botulinum toxin (Botox), as well as being shown to inhibit muscle movement, although by a very different mechanism to how Botox does.

*Also known as acetyl hexapeptide-3 or AH-3

*Read TIA's article Will Argireline Make My Skin Sag?

*Read TIA's article Argireline: What It Does and How It Works

*Read TIA's article Pentapeptides and the Latest 'Botox in a Jar' Potion

Functions:

Argireline is a synthetic hexapeptide consisting of the amino acids arginine, Glutamine, methionine and acetylated glutamic acid. It was formulated in an attempt to visibly reduce wrinkles that occur around the forehead and eyes (PubMed, International Journal of Cosmetic Sceiences). Argireline has been described as “Botox in a jar” due to it being a substrate of botulinum toxin (Botox), as well as being shown to inhibit muscle movement, although by a very different mechanism to how Botox does.

 It is this inhibition of muscle movement caused by Argireline mimicking a protein in a complex called SNARE (responsible for activating muscle contraction), thus destabilizing the complex, preventing muscle contraction and wrinkles from forming. The Internal Journal of Cosmetic Sciences reported a 10% concentration of Argireline resulting in a 30% reduction in wrinkles over the course of 30 days.

There have been some anecdotal reports that Argireline can cause skin to actually sag in the long term. There is some logic to these claims. The body recognises that certain muscles are being inhibited and not used, so it will stop renewing the proteins which give the skin structure and muscle strength in these regions– eventually causing the skin to sag. There have been no scientific studies that show that Argireline causes skin sagging.

Safety Measures/Side Effects:

Due to this ingredient so newly being introduced to the market (2002) there has been no long term double-blind clinical trials published. Shorter term trials regarding the safety of this substance have shown it to be non-toxic and it to cause minimal irritation, even at high doses (International Journal of Cosmetic Science).

Recommended Products with Argireline:

 BRAD Biophotonic Ultra Elastin Lift ($210 in the shop), Benir Beauty BV-9 Platinum Provectus Super Serum ($195 in the shop)

As much as possible, products in the Truth In Aging shop are chosen for their safety profile as well as effectiveness.

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