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Lifeline Stem Cell Daily Defense Complex

Size: 1 oz (30 ml)

Lifeline Stem Cell Skincare Daily Defense Complex uses extracts from pluripotent non-embryonic human stem cells. These stem cells have powerful concentrations peptides, amino acids and signaling proteins that can instruct neighboring cells to create new cells and repair damaged tissue. Because they are suspended in liposomes, Lifeline’s stem cells are more easily delivered where they are needed to stimulate tissue repair, as well as collagen and elastin production. Together, these technologies help reduce the appearance of aging skin. Marta tested it for 30 days and loved it, so you can shop with confidence!

Along with human stem cells, Daily Defense Complex contains enzymes that support the skin’s natural DNA repair process and an antioxidant-rich UGL complex to boost skin’s defenses. Applied daily, the potent formula visibly firms, tones and defends. Dispense two pumps and spread evenly over clean skin every morning. Its lightweight consistency absorbs quickly and layers easily under other products. Daily Defense Complex is proven to diminish the appearance of fine lines and wrinkles while tightening sagging skin.

Tested for 30 days and recommended by Marta:

Human stem cells have got to be the biggest breakthrough in topical anti-aging skin care. Since the technology is so cutting edge, it stands to reason that really serious stem cell brands are few and far between. This is why I was very excited to come across Lifeline Stem Cell Skincare and to test its Daily Defense Complex ($160).

Before I report on my experience with Daily Defense Complex, I want to give some context on the company and its approach to stem cells. Lifeline is a subsidiary of International Stem Cell Corporation (ISCO), a publicly traded biotech company with a stem cell technology that uses unfertilized eggs and is ultimately intended for curing certain diseases. The same technology is being used in the Lifeline skin care line and the company goes out of its way to make some key points and claims: These are not embryonic stem cells, but from unfertilized eggs; these stem cells have signaling proteins and amino acids; they are more powerful than adult stem cells; they are much better than the “human conditioned media” used by some other stem cell brands.

Lifeline also uses liposomes, or nanospheres, that stabilize the stem cells and act as a delivery system. Typically, nanospheres are physiologically similar to cell membranes and on contact merge with them and release their payload of active ingredients into the cells. Not only is this a targeted delivery system, but the release takes place over an extended period of time.

I have been extremely pleased with my experience with Lifeline Daily Defense Complex. My skin is looking very smooth and glowing, and there is a definite impact on wrinkles, especially my forehead lines. The lightweight cream is easily absorbed, not at all greasy and I find that I do not need an additional moisturizer — even on my neck, which tends to be drier and where I’m happily noticing a significant reduction in red, crepey skin. This is one stem cell serum worth finding.

There is, however, more to Daily Defense than stem cells. I’ll deal with the good stuff first. Although Lifeline does mention somewhere on its site that plant stem cells can’t communicate with human stem cells, it has thrown in Phytocell, an ingredient based on argan stem cells, that is supposed to protect and vitalize human dermal stem cells. The formula also has a handful of heavy hitters including collagen amino acids, niacinamide (an antioxidant vitamin B), glucosamine HCI (an anti-inflammatory that may also help with elasticity), yeast and algae extracts, moisture-attracting phospholipids and vitamin C.

Especially interesting for me is micrococcus lysate, a marine microbe that is known to be incredibly resistant to UV light. I always love coming across new ingredients (new to me) and here there is something called Celligent, a complex of antioxidants and DNA protectors. The components are antioxidant ethyl ferulate, rosemary, and disodium uridine phosphate, which supports DNA repair.

In my opinion, the good far outweighs the bad in this serum. I should point out some of the nasties, though. There is retinyl palmitate, which reacts with UV light and has been linked to cancer. Perhaps the effects are offset by the aforementioned marine microbe’s UV protective properties. But, honestly, I don’t know why anyone formulates with RP anymore. For instant gratification, there’s Lipolight, a light diffuser that helps minimize the appearance of wrinkles. A confection of nylop and polymers, it is not for natural ingredient lovers, but EWG rates Lipolight low hazard. The preservatives are the controversial sodium benzoate and phenoxyethanol.

In conclusion, I’m looking forward to continued use — and skin improvement — now that my test is over. In other words, I will be incorporating Lifeline into my normal regimen. This is the ultimate litmus test. I highly recommend it for anyone interested in stem cells and what they can do for their skin.

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Our Take

Human stem cells have got to be the biggest breakthrough in topical anti-aging skin care. Since the technology is so cutting edge, it stands to reason that really serious stem cell brands are few and far between. This is why I was very excited to come across Lifeline Stem Cell Skincare and to test its... read more

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3 Reviews
  • Dana

    I absolutely love Lifeline Daily Defense Complex. The lines on my face (especially marionette) are so much more unnoticeable. My face glows and it evens my skin tone. I am now using the nighttime serum in conjunction with the daytime serum and love them. I am really happy that my marionette lines are barely there and working on them becoming nonexistent, if that can truly be accomplished. My skin tone is very healthy looking- FINALLY!! This product line is one I won't ever be without.

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  • Marta

    Hi Meaghan, they really need something to repair. There are other ingredients that are preventative in this serum, however, I would still say that it is premature for a mid-30-something without wrinkles.

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  • Meaghan

    Hi Marta! Do you recommend stem cells for 35 year old skin? Or does it need something to repair?

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  • Marta

    October 11, 2016


    Hi Melissa, the very best thing is not a topical but ultrasound treatment. Having said that, there are some topicals that do help. Of my ten best round up I would probably choose the Deciem copper and/or the DDG Firming Oil:

  • Melissa

    October 10, 2016


    Hi Marta, what product would be your current number one topical recommendation for sagging? Are there any topicals that actually make a somewhat visible difference in sagging??

  • Marta

    September 22, 2016


    Hi Karen, we are working on getting it in the shop, but the company can't give us a supply date. Rejuvel doesn't have growth factors so its a little bit apples to pears. I'd say they are both good but I would turn to both of them for wrinkles rather than sagging.

  • Karen

    September 22, 2016


    Sorry so many e-mails...I can't find where to purchase this on the TIA site.
    Lifeline Stem Cell Skincare Daily Defense Complex- Help, please.

    Thank you!

  • Karen

    September 22, 2016



    How does this compare to Rejuvel 3D for sagging skin. Sounds terrific, love the ingredients, but need to stay on top of maintain firm skin: face, neck, decollete.

    Thank you!

  • Karen

    September 22, 2016



    I was thinking the same thing...that there needs/should/can be a different way to categorize articles. Thanks for braining it up!

  • Marta

    September 1, 2016


    Hi Marie
    AQ uses human conditioned media, so its a little different. In terms of performance, I would cautiously say it is comparable - but bear in mind that I have been using AQ for years and Lifecell is a new BFF.

  • Marie

    August 29, 2016


    How does this compare with aq serum?

  • Maryam

    August 29, 2016


    Hi Marta ❤️ Can I ask you to categorize your articles, which displays on your sidebar (Show archives by year from just one category). Categorizing an article in this way allows us to easily find posts that cover a specific topic.

  • Water (Aqua)
  • Caprylic/Capric Triglyceride
  • Stearic Acid
  • Butyrospermum Parkii (Shea) Butter
  • Peptides from Human Stem Cells
  • Glycerin
  • Cetyl Alcohol
  • Glyceryl Stearate
  • PEG-100 Stearate
  • Algae Extract
  • Argania Spinosa Sprout Cell Extract
  • Helianthus Annuus (Sunflower) Seed Oil
  • Rosmarinus Ofïflcinalis (Rosemary) Leaf Extract
  • Saccaromyces Cerevisiae Extract
  • Collagen Amino Acids
  • Micrococcus Lysate
  • Phospholipids
  • Isomalt
  • Cetearyl Alcohol
  • Urea
  • Glucosamin HCl
  • Ceteareth-20
  • Niacinamide
  • Carbomer
  • Tocopheryl Acetate
  • Polyvinylalcohol Crosspolymer
  • Retinyl Palmitate
  • Sodium PCA
  • Sodium Starch Octenylsuccinate
  • Calcium Pantothenate
  • Disodium EDTA
  • Maltodextrin
  • Panthenol
  • Sodium Ascorbyl Phosphate
  • Lecithin
  • Ethyl Ferulate
  • Polyglyceryl-5
  • Trioleate
  • Pyridoxine HCl
  • Ubiquinone
  • Sodium Benzoate
  • Silica
  • Nylon-12 Fluorescent Brightener 230 Salt
  • Hexylene Glycol
  • Disodium Uridine Phosphate
  • Aminomethyl Propanol
  • Ethylhexyglycerin
  • Caprylyl Glycol
  • Phenoxyethanol
  • Citric Acid.
Dispense two pumps and spread evenly over clean skin every morning. Its lightweight consistency absorbs quickly and layers easily under other products.

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