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6 Hi-Tech Breakthroughs in Anti-Aging

Hi-tech Skin Care
April 21, 2015 Reviewed by Marta 11 Comments

UPDATE: Read our updated list of high-tech beauty breakthroughs.

Say what you like about the big beauty brands, they do invest in research and development and they have teams of incredibly experienced scientists who have come up with skin care breakthroughs such as ceramides or glycolic. So when the pointy heads at L’Oréal start to mention medical breakthroughs on anti-aging frontiers, I sit up and take notice. This is one of the reasons why glycans are on my radar. Read on to find out the other reasons, as well as what other high tech beauty breakthroughs I have identified.


Glycans are macromolecules, or polysaccharides, and without them the cells in our bodies can't communicate with each other. Glycans can, for example, send a message to produce collagen. In fact, there are so many different glycans that a whole new branch of science has been established called glycobiology. MIT says it is one of the sciences that will change the future of medicine. The study of glycans has recently opened up new insights into skin aging. L’Oreal’s researchers say that glycans are the new frontier in skin care. It has now been clearly established that glycans are major constituents of the skin and play a decisive role in skin homeostasis. As well as delivering messages at the cellular level, they play a role in the structure of skin tissue.

My interest in glycans was recently piqued when I was introduced to Moana, an all-natural and extremely effective skin care brand with marine glycans (from red seaweed indigenous to New Zealand) as its star ingredient. Moana Serum ($119.50) is almost 100% glycans.

Matrixyl Synthe'6

There are dynasties in politics and dynasties in skin care. Matrixyl Synthe 6 comes from a long line of synthetic peptides, but don’t go dismissing it as the Jeb Bush of cosmetics. Matrixyl® is a trademark of Sederma and is the name given for a series of anti-wrinkle actives (the first was launched in 2000) that contain a specific “matrikine,” a peptide that can link to a matching cell-surface receptor. Matrixyl has always been a reliable ingredient and the latest is Matrixyl Synthe’6 (palmitoyl tripeptide-38). As the name implies, Matrixyl Synthe’6 stimulates six major constituents of the skin matrix and the dermal-epidermal junction, including collagen and hyaluronic acid.

Still a new kid on the block (and expensive as a raw ingredient), Matrixyl Synthe’6 is slowly appearing in serums. You can find it in Lumavera Anti-Aging Serum ($120), and it is one of the additions to the new formula in Your Best Face Correct ($150 in the shop).

Far Infrared (FIR)

On my radar for a couple of years now, I have been fascinated by far infrared (FIR), part of the electromagnetic spectrum. In Asia especially, it has been investigated for its therapeutic effects, especially in wound healing. I am currently researching the development of a device with far infrared. Believe it or not, we all emit infrared wavelengths. Far infrared waves are the longest rays in the light spectrum and easily absorbed by the body to a depth of up to three inches. There they can do useful things, wound healing being one of them. A Japanese study found that wound healing “was significantly more rapid with than without FIR.” Findings also revealed “greater collagen regeneration and infiltration of fibroblasts."

Until I’ve figured my device out, we can settle for Far Infrared Ceramic Powder, a ceramic powder that emits far infrared wavelengths. E’shee has made FAR Ceramic Powder a feature of its most recent addition, the above mentioned Alpha Omega and E’shee KI Therapy Serum - Elixir of Life ($189 in the shop).


An ingredient that I’ve been taking a strong interest in is perfluorodecalin, a perfluorocarbon that mimics the blood’s ability to carry oxygen to the skin cells. It is used in wound healing therapies and for treating acne. Although, I haven’t found research to back this up, it is postulated that perfluorodecalin promotes collagen production. On the other hand, there is research showing that perfluorodecalin boosts moisture in the skin. It allows the skin to breathe to optimum levels and to self-regulate better in polluted environments. Also, it boosts SPF performance.

I made perfluorodecalin a key ingredient in Truth Vitality Treatment Gel ($49 in the shop), face mask and conductivity gel to be used with ultrasound and microcurrent devices. Lumavera Oxygenating Masque ($70 in the shop) has it in the form of perfluoroisohexane, which essentially works in the same way to dissolve oxygen.

Trifluoroacetyl tripeptide-2

I am always on the lookout for actives that promote elastin in the skin. This is the highly elastic protein in connective tissue that allows many tissues in the body to resume their shape after stretching or contracting. The elastase enzyme attacks structural proteins, e.g. elastin, and so ingredients that inhibit it are a good thing. A peptide called Trifluoroacetyl tripeptide-2, also known as TT2, does just that and, as a result, reduces sagging and slacking.

You can find it in E'shee Clinical Esthetic Alpha and Omega Gene Therapy Eye Cream ($284 in the shop).


So you thought you knew all about plant stem cells? Well, this one is a little different. It is made by Sederma (the company that makes Matrixyl Synthe’6) and comes from Globularia Cordifolia, a kind of daisy. Sederma says that it mimics the body’s defense produced by “hormesis”. It seems that stress is good for you (bring it on, New York City!) Really. As scientists get to understand hormesis, there is a growing body of thought around the idea that mild repetitive stress has anti-aging effects. By mimicking hormesis, Resistem reduces micro-inflammation caused by toxins. Sederma says that Resistem protects the skin’s own stem cells and stimulates sirtuin-1 (an enzyme that contributes to the longevity of cells).

I first came across Resistem in BRAD’s Sublime Youth Creator Gel-Cream ($245) and more recently in Sciote OMNI Phyto-Cell Crème ($110 in the shop).

  • April 24, 2015

    by Lorna

    I'm 42 and my blackheads and I have been together (unhappily) for approx. 30 years. I firmly believe that if the world were to end in a nuclear catastrophe, the only things left (apart from cockroaches) would be my blackheads! They have resisted all my efforts over the years to destroy them, including AHA's, peels, exfoliators, clay masks, (etc), and yet they stubbornly remain.
    I've been introduced to many amazing products through TIA that have been brilliant for my other skin concerns, but I must admit that I've all but given up hope that there may be a product or treatment out there that can shift these blackheads for good. However I've never tried anything like the Labelle Ultrasonic Skin Scrubber, and I find myself daring to believe that finally this may be the answer!
    As I'm in the UK I realise that you may feel I'm not eligible to review this device as I might need an adaptor if it has a US plug (although I do have a US/UK adaptor already). But even if I'm not chosen I can't wait to see what your reviewer makes of this product, especially if it can annul my three decades long relationship with my blackheads!

  • April 23, 2015

    by Christian

    I am a male with sensitive skin and always looking for ways to gently exfoliate and clean my pores. Like Terry I had one of these devices used on my skin some time ago by an esthetician and the effect was incredible. I would love to get one to use and review for Truthinaging.

  • April 22, 2015

    by Tiffany

    The Labelle Ultrasonic Skin Spatula sounds awesome! Recently I've been having more issues with my skin then normal and its hard to treat because there's so many different issues (clogged pores, dryness and flakiness, oily nose, hyperpigmentation). I'm a clarisonic user, but it doesn't feel like it's helping like it used to :/ I would love to see if this product might be the next step!

  • April 22, 2015

    by Steph

    All of these are great actives except, it seems to me, Matrixyl Synthe'6. I'm mystified by this one. The 2 month 'after' photo in Sederma's own marketing literature shows a person who has far fewer wrinkles, but at the expense of the collapse of her under-eye zone. The area looks puffy and saggy, as if key support structures in the skin have given way. The nasojugal groove is deeper and extends an additional half inch below the eye than it did at the start of the study.

    Another manufacturer's trial results I found showed even odder results - more puffing and strange re-shaping of the under-eye. I'm surprised these photos are being used for marketing. I guess people just fixate on wrinkles, rather than the overall result.

    This doesn't mean that palmitoyl tripeptide-38 might not a have a valid role as part of a clever recipe of combined peptides and other actives, but I am still puzzled by the positive talk about it. I almost felt reluctant to mention it, like it's the elephant in the room. Just my two cents!

  • April 21, 2015

    by Imelda

    These Hi-Tech breakthroughs make me want to go back to school and revisit my science subjects! Anyway, I wonder if the Trophy Skin Labelle Ultrasonic Skin Scrubber/Spatula would really be necessary if one follows a strict regimen of cleansing, exfoliating with the use and application of excellent products, such as those in the Sciote Skin line. I say so because after I tested the Sciote Skin Advanced Micro Derm Creme ( I found that clogged pores were a thing of the past and smooth prepped skin last for days. So can the Trophy Skin Labelle Ultrasonic Spatula do much more? I would love to be the doubtful tester...

  • April 21, 2015

    by Barbara Wicklund

    I have been trying to decide if and which one of these to try! Would love to use and review this!

  • April 21, 2015

    by Terri

    Oh my! I have been wanting one of these forever!
    Amazing device it is, had one used on my skin
    during a facial I had and it was awesome. Would
    absolutely love to use this on my skin at home, thus more frequently than once a month. Please please
    pick me to use on this tired old skin of mine!

  • April 21, 2015

    by Frances

    I would love to try the Labelle Ultrasonic Skin Spatula. My skin is very uneven, I'm noticing enlarged pores, flaky areas around my nose, chin and forehead. Yet still experiencing oily skin in those same areas. Along with dull skin on my face , neck and chest. My skin needs HELP!

  • April 21, 2015

    by ilene

    Would love to try this innovative skincare product! Sounds amazing and it seems it would make a difference in my skincare routine.

  • April 21, 2015

    by Tina

    I'd love to review the Labelle Ultrasonic Skin Spatula! My clogged pores all took a vote, and it was unanimous---I need this device in my life. :-)

  • April 21, 2015

    by Kathy

    I would love to try the Trophy Skin Labelle Ultrasonic Skin Scrubber. I would be a great tester since I already have a routine of brushing my face twice a day. But I do have a couple issues that brushing alone is not overcoming. I have a scaley rosacea spot on each cheek. strange rough bumps at my hairline and fine lines on forehead with light crows feet. All in all not bad for 51 and I want to keep it that way!

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