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A&G Skin Solutions Active Serum and four cell growth ingredients

Is a Solution for:
Sagging Skin
May 14, 2008 Reviewed by Marta 38 Comments
Today I received an email from Ildi Pekar, my esthetician. She wanted to share with me a new product she has been trying out for the last two weeks with great results. She says her skin looks younger and wrinkles are diminished (not that she really has any compared to tortoises like me). The product is called A&G Skin Solutions Active Serum and it has four very interesting ingredients that promote cell growth.

This is a product that takes the opposite approach to anti-aging than, say, a retinol. Retins and hydroxy acids work by exfoliating to make the skin think it has had a trauma so that it starts to make new cells. The problem with this (other than the fact it is irritating) is that you eventually reach the Hayflick Limit: cells can't divide and reproduce indefinitely - if they are healthy - and so reach their limit at 52 divisions before dying completely. Cell growth ingredients are different because they aim to replace or augment the natural growth agents that we lose as we get older.

The first of these cell growth ingredients in A&G Skin Solutions Active Serum is TGF-beta (1-3). This is a 'super' protein that controls cell functions such as growth and proliferation. It also regulates cell death. Studies at Cornell, Vanderbilt and Jefferson show that TGF-beta stimulates collagen and elastin production. Jan Marini uses TGF-beta (1) in her product line called Transformation (pictured below).

Photobucket

Next there is PDGF (platelet derived growth factor). This is also a protein that regulates cell growth and division. The third protein in AG Skin Solutions Active Serum is granulocyte-macrophage colony-stimulating factor (GM-CSF). This one stimulates stem cells. Finally, there are more cytokines (molecules that send out controlling signals) called interleukins.

In addition, the two doctors behind A&G have included an anti-oxidant concoction of vitamins C and E, evening primrose and Pycnogenol, an anti-oxidant from a maritime pine tree that grows in France. The manufacturer of Pycnogenol claims that 170 studies and trials have been pubished over that last 35 years backing it up as an anti-oxidant.

As Ildi pointed out, at $190 this product isn't cheap. But if my research bears out, it may prove to be well worth it. Anyway, I pressed the buy now button.  We'll report back.
  • April 6, 2009

    by Justine

    Ummm, I think I meant Bess!

  • April 6, 2009

    by Justine

    Michelle,

    I have read different reports about topically applied estrogen and its role in supporting collagen renewal. The theory seems to be that is works by signaling to cells like fibroblasts that something is up and the those cells need to kick into gear. Fibroblast cells support synthesis of collagen, as well as other stuff, in the extracellular matrix.

    The similarity between like A & G, TNS, etc., is that they use actual fibroblasts as the external signal rather than a middle man, estrogen. In that respect, it seems that both products are working on the same mechanism, but I don't think that is the same thing as saying that one is acting like the other. I could be way off though.

  • April 6, 2009

    by marta

    Hello Bess,

    This is a complex question. First, Copley wrote a piece on topical estrogen - or I should say, topical ingredients that mimic estrogen. Basically, these are linked to cancer. It is why people don't like parabens, they mimic estrogens. However, this is a controversial area and the research is contradictory. Copley's piece is very informative: http://www.truthinaging.com/2008/12/what-is-it-estrogen-in-my-face-cream.html

    As to whether, human fibrobast conditioned media - the active A&G et al - behaves like topical estrogen. Not that I know of and I've just checked back over my earlier posts.

    And yes it does go quickly. I've reduced my current use of Reluma to once a day.

  • April 4, 2009

    by Bess

    Dear Michelle,

    I'm a real consumer. Does anyone on this forum know anything about topical estrogen? I read somewhere, perhaps a Marta post, that the cell growth material like that used in A&G, TNS, Reluma, Revive, etc. behaves similarly to topical estrogen, I just purchased my second bottles of A&G serum, face and eyes. It's amazingly effective, though I am trying to justify the price. A&G recommends using two pumps in the AM and a pump in the PM. At this rate, it doesn't last long.

  • March 15, 2009

    by Michelle

    Wow,

    Everyone seems to love this A & G product and has had great results with it except for Marta. Since "Jennifer" and "Sylvia" were marketers/fakes, and Marta didn't have dramatic results with this product, I'm starting to question the integrity of these other comments about how great this product is (no offense to any real consumers who posted). Can anyone tell me the difference between ReLuma and A & G? I thought they used to be related somehow. I think Reluma is about $60 less, but is Reluma or A & G better, and why?
    Also, how does Image Skincare's Ageless Total Anti-Aging Serum compare since it was listed as top of the most updated Five Best anti-aging serums? It's confusing that this keeps changing. If anyone could respond to my questions, it'd be greatly appreciated! Thank you!

  • February 28, 2009

    by Anne

    Bees, Linda, Mary and Everybody!

    A&G is the real thing!! I've been using it for 5 months and yesterday I met a friend who I didn't see for a year and she asked me right away: what happened? What did you do to your face? You're glowing!! It's true. I feel like I have new skin. I tried everything else on this web site that is on the top 5 lists and NOTHING comes close. Get in on line and throw away everything else you have in your cabin. Really important is not to use it with RetinA or Renova. It does work great with peptides. No more dry skin, no more deep wrinkles and it even took away my break outs. They're on to something over there........

  • February 18, 2009

    by Mary from Phoenix

    Hi Bess and Linda,
    I agree with you, I am a watch dog when it comes to cosmetics. I tried TNS recovery and I did not like it at all. I did not hear of A&G until I saw a blog about it. After doing some research, I discovered this site. I've been using it for 2 months now and I am very pleased. My skin does not dry and Marta is right about the deep wrinkles. I could not find it here and been ordering it from online. Anyone knkows where I can find it in Phoenix?
    Thanks
    M

  • February 16, 2009

    by Linda Kang

    Bess,
    I agree with you regarding A&G and I too use it and recommend it to my patients. I think its the best product to date and will be along time till we see another product like it in the market.

  • February 6, 2009

    by Bess

    Dear Marta, et al,

    Thanks for this site. Like you, I too am a label reader, ingredient hound and the higher the price tag, the higher my expectations for results. I discovered A&G through this site, and can report with confidence that this is a highly active and effective product. My frame of reference is TNS, which I've used consistently on the recommendation of my dermatologist for the last four years. The difference is that A&G is the only thing I put on my face the last three months, and I live in Chicago! The hydration quality is excellent. Also am using the eye product. My skin is glowing. It is worth noting that A&G advises against using RetinA or Renova in combination with the serums.

  • January 28, 2009

    by marta

    No I'm not using it. I switched to ReLuma.

  • January 27, 2009

    by Zoe

    So, Marta: it's been seven months since the original post, I believe. How do you like A&G now and are you even still using it?

  • January 8, 2009

    by Linda Kang

    "FDA does not "approve" health care facilities, laboratories, or manufacturers. FDA does inspect product manufacturers to verify that they comply with good manufacturing practices". A&G products are produced in a facility that was inspected by the FDA and shown to comply with good manufacturing practices, I've seen a proof of that and this what I was trying to say.
    Next time you don't need to write to the FDA just visit their website its easier..;)
    http://www.fda.gov/consumer/updates/approvals093008.html

  • January 8, 2009

    by marta

    How interesting that you should have seen an FDA "certificate". I wrote to the FDA and this is the response - in a nutshell saying the law does not permit them to approve cosmetic facilities:

    "FDA can and does inspect cosmetic manufacturing facilities to assure cosmetic product safety and determine whether cosmetics are adulterated or misbranded under the Food Drug and Cosmetic Act or the Fair Packaging and Labeling Act (http://www.cfsan.fda.gov/~dms/cos-214.html). However, these laws do not give FDA the authority to approve cosmetic laboratories, cosmetic products or their labels before marketing, or require pre-market notification to the Agency of finished cosmetic products and their constituent ingredients. However, FDA may pursue enforcement action against violative products, or against firms or individuals who violate the law."

  • January 7, 2009

    by Linda Kang

    Thank you Marta,
    I agree, he did mention to me that their concentration is way higher than the others and their methods are more advanced which justify their pricing. I do remember ReLuma, its been in the market longer than A&G if I remember correctly. I remember we did not like it. Mostly because the product did not perform as good as TNS or Biogel and some patients reacted to it badly. One of the nurses is tell me now that Reluma changed color a week after opening the bottle. I heard it was pulled out of the market or something like that. TNS-recovery smells bad and its hard to keep patients on it longer than a month.
    I love google maps, its a good tool if you are in the market to buy a house. But in fairness, I am familiar with the lab. they are using and its FDA approved. I know this for a fact, because we are in the process of carrying the A&G line at the clinic and they did provide us information about their production sites and showed us their FDA approved certificate.
    My question for you Marta, do you think GF based products are the future in skin care? You are the best person to answer this ;)

  • January 7, 2009

    by marta

    Hi Linda,
    I think that these products are rather similar. A&G's founders used to be associated with a product called ReLuma. If there is a difference it would be 1) the amount of growth factors used (ReLuma has nine, some of the others have three or four) and 2) how the stuff is made. I've talked to some formulators who won't touch human growth conditioned media because of hygiene concerns. So how is it sourced and are proper lab conditions used to make the serum would be key questions. Google maps is a useful resource: I did a search on the address of one of these serum-makers and the satellite picture clearly showed a condominium. Not exactly a hi-tech, FDA approved lab.

  • January 6, 2009

    by Linda Kang

    I am 47yrs old dermatologist. I've seen them all and I always keep myself up to date with new products. I have to say that this site is just great and I applaud those who are keeping it up. I got to learn about A&G through this website 6 months ago or even longer and always wanted to try it but never go to it mostly because of my schedule. Nevertheless, I kept reading about it online and through some reviews. Recently during a seminar, I met one of the doctors of A&G and I got the chance to talk to him about it. I didn't mention this site to him or let him know that I was a doctor. I was impressed with his knowledge and was convinced to try it. The product and results were great, I agree with Marta that packaging can use some help. Being a doctor myself I can understand doctors are not good with artistic things. I placed 5 of my patients on the A&G active serum and all loved it. The results were stunning in comparison with other similar products which I sell in my clinic. The question here is, why A&G is different than the other brands such as TNS-recovery, biogel and Revive? All of these products uses the same technology or similar scientific background. I asked some of my colleagues this question and never got a satisfying answer. If anyone has an answer for me, I will love to hear it.

  • December 16, 2008

    by Anne

    So I've been using this for over a month now and this is the real thing. You do have to use it twice a day and put a full pump on. On days that I skip a dose or put less I can see a difference but when I put it twice a day with a good moisturizer (I use Origins, Youthtopia!) I get a lot of people asking me what have I done to my skin. I'll be using this for a while and although it's SO expansive, I tell my self that I used to buy so much shit that didn't work... at least now I only need this and my moisturizer.

  • December 7, 2008

    by Barbara

    Thank you Marta!!

  • December 6, 2008

    by marta

    Hi Barbara
    I don't have them for the serum, but I do for the eyecream and, as I recall, they were very similar:
    Water (aqua), human fibroblast conditioned media, acetyl
    hexapeptide-8, glycerin, hesperidin methyl chalcone, steareth 20,
    dipeptide 2, palmitoyl tetrapeptide-7, butylene glycol, evening
    primrose seed extract, polysorbate 20, chrysin, n-hydroxysuccinimide, palmitoyl oligopeptide, aminoethylphosphinic acid,
    xanthan gum, green tea leaf extract, grapefruit extract, lactic acid,
    bergamot oil, phenoxyethanol, 1,2-hexanediol, caprylyl glycol.

  • December 6, 2008

    by Barbara

    Anybody can post ingredients list for A&G Skin Solutions Active Serum? I'd very appreciate it. Thank you!

  • September 14, 2008

    by Southernbreed

    <p>It is very nice to read A$G website, plenty of disclosure and real information. Many other sites of "similar" products websites just pushed you to telemarketeer without disclosing anything about the companies. </p>

  • July 19, 2008

    by Mia Shcmidt

    <p>The active serum i absolutely amazing!It is the nest best thing to surgerey and botox itself! I noticed a difference in less than a week! Worth every penny!</p>

  • June 10, 2008

    by Cristina

    <p>I not tried the J&M product but I have tried the A&G skin solutions serum and I love it! I tend to try anything new on the market and most are a waste of money but this one really does work- the fine lines around my eyes have almost disappeared and my skin is a lot firmer. It's an amazing product and I can't wait to see what else they have. </p>

  • June 1, 2008

    by jan Raza

    <p>Hi Marta, my sister lasted her for one month exactly. I used a lot of it at the beginning but last week I used less. My skin feels great now, and the redness under my chin went away. she's going to wait for a week before she get another one just to see if her skin changes. <br />
    p.s. email A&G regarding the marketers (Sylvia and Jennifer) and demand an apology. They respond fast and post their respond here for us to see.</p>

  • May 29, 2008

    by Marta

    <p>Well, well, well Sylvia. What a coincidence that you should have the same email address as the previous commenter called Jennifer. I thought you're comments were suspiciously unauthentic. I don't mind marketers fessing up to who they are, but don't come on my site posing as a consumer. If you won't be able to because you are banned.</p>

  • May 29, 2008

    by Marta

    <p>I've been using it for nine days. I think there are results but not dramatic so far. I will give it several weeks longer before I review it. If it really lasts barely a month then I would conclude that it is ridiculously overpriced. </p>

  • May 29, 2008

    by Sylvia

    <p>I'm using the A&G twice a day-morning and before bed. One bottle lasts almost a month. Most importantly- it works great and is well worth the expense.</p>

  • May 29, 2008

    by Jennifer

    <p>I have used the Active Serum twice daily for 9 days and I already see dramatic results.It's by far the best product I have ever used.</p>

  • May 23, 2008

    by jan Raza

    <p>I thought you gals might enjoy this, my husband is using it too now and his skin improved more than mine. He use it after shaving and now he loves going to work ;) </p>

  • May 22, 2008

    by Marta

    <p>Depends how I feel my skins looks, but usually either Image Skin Care serum or Image Skin Care Ormedic Balancing Bio-Peptide (which is really a moisturizer, but a good one).</p>

  • May 22, 2008

    by Kathy

    <p>Okay, sounds reasonable. The bottle only has like .6 oz, that I don't want to use it more often than I should. What are you using in the evenings if not the AG?</p>

  • May 21, 2008

    by Marta

    <p>My esthetician, Ildi Pekar, says "For the best result I would use the Ag serum twice a day for two weeks. You only need a small amount. I been using my for a couple weeks and still feels pretty full. And maybe after two weeks just in the morning."</p>

    <p>I just started using it yesterday (mornings only). A little seems to go a long way.</p>

  • May 21, 2008

    by Jan Raza

    <p>Hi Kathy,<br />
    I use it twice a day in the mornings and before bed. The bottle I think is perfect size, especially when you think about how long it takes to generate the serum. I emailed them to ask about other products and they said the rest of the A&G line will be launched on the Vegas show, they have the link on their web site (www.agskinsolutions.com) anyone here is going to the vegas show that can report to us about their products and news? I am telling you gals, this will be the next big thing. </p>

  • May 20, 2008

    by Kathy

    <p>Are you gals using it once a day or twice a day? I used it last night and loved it But the bottle is so teeny, I hesitate to use it more than once daily. And if you're using it once a day, what do you use in the morning? thanks!</p>

  • May 17, 2008

    by Marta

    <p>The image is of Jan Marini's Transitions - also mentioned in the post. I couldn't get hold of a pic of the A&G, but I'll take a product shot when my order arrives.</p>

  • May 16, 2008

    by Jan Raza

    <p>my sister is using it and her skin now is gorgeous, I just got mine 3 days ago and my skin never felt better. I emaild the company and they said a full launch of the product will start in September for now its only available though their web site. </p>

  • May 16, 2008

    by Mrs. Smile

    <p>got it, loved it, want more of it..finally something really works ..<br />
    the picture in the article is not the right picture of the product,,hmmm why is that? where can I get it in NY?</p>

  • May 16, 2008

    by A&G Active Serum User

    <p>The best product in the market hands down, I bought it from their web site agskinsolutions.com . I am loving it !!!</p>

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