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Hydropeptide Cellular Transformation Growth Serum

Is a Solution for:
Sagging Skin
November 5, 2008 Reviewed by Marta 8 Comments
These days, more than ever, if I'm going to invest $100 in a face cream, I want to be sure that it will deliver a bang for the bucks. So I browsed the ingredients list of Hydropeptide Cellular Transformation Growth Serum ($119) in detail before reaching for my credit card. What had initially caught my eye is that Hydropeptide Serum contains several growth factors.

I was first introduced to growth factors by A&G Skin Solutions and then by a serum that I have found to be very effective called Reluma. They are essential to formation of new skin. As part of the first response to injury, for example, platelet-derived growth factor (PDGF) and transforming growth factor-beta (TGF-beta) are released and ensure that cells get their act into gear. They can also prevent cancer cells from developing. Definitely worth my hard-earned cash.

Hydropeptide Serum has three growth factors: Recombinant Epidermal Growth Factor (EGF), Recombinant Transforming Growth Factor-â1 (TFG- â1), Vascular Endothelial Growth Factor (VEGF). Although ReLuma has nine different growth factors, Azure's serum was beginning to look pretty good especially as there is also palmitoyl tripeptide-3, dubbed synthetic collagen (you'll also see it go by the name of Syn-Coll) because it mimics the skin's ability to produce collagen.


I was heartened by the liberal use of antioxidant green tea and hydrolized oats, as well as a strong, stable and non-irritant form of vitamin C.

Of borderline interest are DMEA, which is supposed to counteract sagging skin but with scant evidence to prove it, and zinc gluconate, a natural detoxifier that has been tried as an acne cure with mixed results.

Unfortunately what could be a very good product is marred by an overly generous handful of ingredients that I would prefer not to be paying good money for. Sodium polystyrene sulfonate is a film former that is used to superficially mask the appearance of wrinkles. There are three silicones and there are additional potential irritants in the form of triethanolamine, phenoxyethanol and every paraben known to man. My flexible friend stayed in my purse.

Ingredients in Hydropeptide Serum

Water, Camellia Sinensis (Green Tea) Leaf Extract, Tocopheryl Acetate, Retinyl Palmitate, Panthenol, Tetrahexyldecyl Ascorbate, Magnesium Aspartate, Zinc Gluconate, Copper Gluconate, Hydrolyzed Oats, Sodium Hyaluronate, Hydrolyzed Hibiscus Esculentus Extract, Dextrin, Hydrolyzed Soy Protein, Dipeptide Diaminobutyrooyl Benzylamide Diaceate, Acetyl Glutamyl Heptapeptide-3, Dimethyl MEA, Acetyl Tyrosine, Dipropylene Glycol, Palmitoyl Tripeptide-3, Palmitoyl Hydrolyzed Wheat Protein, Recombinant Epidermal Growth Factor (EGF), Recombinant Transforming Growth Factor-â1 (TFG- â1), Vascular Endothelial Growth Factor (VEGF), Butylene Glycol, Sodium Polystyrene Sulfonate, Glycerin, Glycereth-26, Menthyl Lactate, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Squalane, Cyclohexasiloxane, Cyclopentasiloxane, Simmondsia Chinensis (Jojoba) Seed Oil, Polysorbate 60, PEG-12 Dimethicone, Thiotic Acid, Hydrogenated Lecithin, Acrylates/C10-30 Alkyl Acrylates Crosspolymer, Xanthan Gum, Triethanolamine, Tetrasodium EDTA, Phenoxyethanol, Methylparaben, Ethylparaben, Propylparaben, Butylparaben, Isobutylparaben

  • August 6, 2013

    by Huy

    Thanks for the review, no wonder there's no ingredient list on their website ;)

  • March 26, 2011

    by Justd

    Dang margaritas, a whole year since my last, but obviously sufficient...ok, re-read this, what I should have asked is there an update to this product, does anyone know, I did't check the ingredients, as I should've on their site..and I only had one!

  • March 26, 2011

    by Justd

    I recently received some samples from Hydropeptide, wanted to try out their various face products, and curious if anyone else has used any of them. I really like their Dark Circle under eye cream, I had purchased it in a kit and used it after my battle with Lilash and it eradicated all vestiges of discoloration I incurred with that product. Now I'm curious, having read this article if anyone has an update. I have tried their Face Anti-Wrinkle Repair & Prevent Treatment Nd Anti-Wrinkle Cellular Transformation Serum and like them very much. I really need a good face plumper and fine line reducer for my face, and I woke up feeling a suppleness and softness to my face that hasn't been there for a while from the stuff I've been trying out. I really liked & was using Olay's Regenerist before I came into the knowledge of what I was using on TIA, but it kept me feeling moisturized thru out the day... These three products seem to really be good, any additional insights on them anyone? Trying to find that elusive moisturizer that will do it all ;)

  • February 12, 2009

    by JulieK

    Terrie- how has the serum worked out for you longterm?

  • November 6, 2008

    by Marta

    <p>That's good to hear. The growth factor ingredients look really good. Please do let us know how you get on.</p>

  • November 6, 2008

    by Terrie Bell

    <p>Well I called HydroPeptide today (800-932-9873) and spoke with one of their customer service representatives and she told me the preservatives are only included to maintain product stability and increase the longevity of the products ingredients. You have me second guessing this, but I've been using the serum for almost 3 weeks and so far it seems to be giving me "real" results...I'll check back with you later and let you know how everything is going.</p>

  • November 6, 2008

    by Marta

    <p>Well, its not that its a negative so much as it just leaves a film on your skin so the wrinkles are harder to see. So I would feel I am paying for something that just has a superficial action. I'd be more worried about the silicones and preservatives in this product though.</p>

  • November 6, 2008

    by Terrie Bell

    <p>That's odd that you think having "Sodium polystyrene sulfonate" is a negative. HydroPeptide's line came highly recommended to me by my dermatologist because she said ingredients like that helped you see immediate results, whereas all the other ingredients you mention focus on long term results. What do you think?</p>

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