Be prepared to stampede the shopping aisles for Boots No 7. It happened in 2007 and it's about to happen again. Scientists have endorsed an anti-wrinkle cream, Boots No7 Protect & Perfect Intense Beauty Serum, that costs about $30. In the US, the serum is called Refine & Rewind.

The scientists published their study in the British Journal of Dermatology yesterday (Tuesday, April 28) and it showed that 70% of individuals using Protect & Perfect had significantly fewer wrinkles after 12 months of daily use compared to volunteers using a placebo. Dermatologists at The University of Manchester carried out a clinical trial on 60 volunteers with typical signs of sun-damaged skin.

This is the same research team, headed by Professor of Dermatology Chris Griffiths, that reported last year that the original No7 Protect & Perfect Beauty Serum (this year's version is supposed to "richer") stimulated the production of fibrillin-1, a protein that promotes elasticity in the skin.

The previous studies were fairly short-term, so this year-long study (a rarity in the cosmetic world) is bound to cause a sensation. Griffiths' conclusion is that the Boots serum is as good as a prescription retinoid. In actual fact, Protect & Perfect is basically retinyl palmitate (a relatively mild form of vitamin A) and pentapeptide-3, which is Matrixyl. The ingredients are below - note that I haven't been able to find the ingredients for Protect & Perfect Intense, but would guess that they are fairly similar.

I reviewed the original in its US incarnation as Refine & Rewind back when I was starting this website. Before I got to see much in the way of results, I had to give up using it because my skin reacted badly to it. You can read my 'reviewed and rejected' here.

Related posts

A round-up of products that contain retinol and Matrixyl


Cyclopentasiloxane, Aqua, Butylene glycol, Dimethicone corsspolymer, Cyclohexasiloxane, Glycerin, Dimethicone copolyol, Sodium ascorbyl phosphate, Polysorbate 20, Magnesium sulphate, Phenoxyethanol, Sodium PCA, Retinyl palmitate, Methylparaben, Propylene glycol, Lupinus albus, Carbomer, Butylparaben, Ethylparaben, Propylparaben, Isobutylparaben, Panax ginseng, Morus alba, Tocopherol, Palmitoyl pentapeptide-3.