My latest project is to return to some of the tried, tested and true to test them specifically on deep wrinkles. In my case, they are the horizontal forehead lines (one of which first appeared in my 20s). A few months ago a close friend, who I hadn't seen for two years, came to visit. After about half an hour, she remarked that my forehead was less lined. At the time, I was using Dr Pugliese's Circadia Myo-Cyte Rx Serum. So I decided to go back to it. I can confirm that it goes straight to work on deep wrinkles.


At $150 for half an ounce, it is expensive and, unless you're flush, best saved for the really stubborn wrinkles.   Circadia Myo-Cyte Rx Serum (catchy name, huh?) is based on blessedly simple formulation of some excellent anti-aging ingredients: hyaluronic acid, peptides, amino acids, vitamin C and a couple of botanicals.


The three peptides: acetyl hexapeptide, palmitoyl pentapeptide, palmitoyl tetrapeptide. The first is the neuropeptide that relaxes the facial muscles and thereby reduces expression wrinkles. The second and third team up to form Matrixyl 3000, a potent booster of collagen production. Amongst the amino acids, is one of my favorite ingredients, L-carnosine. Carnosine actually extends the Hayflick Limit. Skin cells can only reproduce themselves around 52 times and then that’s it, they’re a gonna. Carnosine extends their ability to reproduce to just over 60 times, making it a real anti-ager. And then there is threonine, which helps keep connective tissues and muscles throughout the body strong and elastic. Finally, there is L-glycine, an amino acid that helps the body produce proteins.


The botanicals, passion flower and chamomile, both contain apigenin, a flavenoid that is anti-inflammatory, anti-oxidant, anti-irritant, lightening agent, anticarcinogenic, and antiseptic. Rosemary contains carnosol, an antioxidant. If only Dr P could find alternatives to parabens, propylene glycol and diazolidinyl urea, he'd have an absolute winner.


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Ingredients in Circadia Myo-Cyte


Water, Hyaluronic Acid, Acetyl Hexapeptide, Palmitoyl Pentapeptide, Palmitoyl Tetrapeptide, Ethoxydiglycol, Tretrasodium EDTA, Passion Flower Extract, Rosemary Extract, Chamomile Extract, Magnesium Ascorbyl Phosphate, Amino Acid Complex (L-Carnosine, L-Threonine, L-Glycine), Propylene Glycol, Diazolidinyl Urea, Methylparaben, Propylparaben.