My main motivation for trying out Cosmedix Affirm (around $60) is that it is a product twin. It is not identical, but extremely similar in formulation to Sircuit Skin’s Addict, while being much less expensive. We are outing products that charge top dollar for white label formulas on our YouTube series, Twin Tuesdays and I wanted to see if it was worth taking a chance on the lower priced Cosmedix Affirm. And I have to say that I have found it to be very good.

Cosmedix Affirm is a lightweight serum and I have been testing it once a day on my forehead for exactly one month. I see visible results in the form of tighter skin and the horizontal forehead lines are definitely fainter. It reminds me of the old formula Osmosis Replenish in terms of performance and I have been using it with Skin Nutrition Cell CPR layered over the top.

Affirm is an antioxidant powerhouse.  Like Osmosis Replenish, it has catalase. This enzyme is super useful in that it is the catalyst that turns hydrogen peroxide into water and oxygen, which is naturally occurring but builds up over time.

Meanwhile one of the ingredients in Affirm and not shared by Sircuit Skin is thioredoxin, a kind of antioxidant protein that has a role in cell-to-cell communication.

Join the conversation on our Facebook Fan Page!

Ingredients that they do have in common include peumus boldus extract. This is a tree native to Chile and a well-known antioxidant and free radical scavenger. It is also called diacetyl boldine and is marketed under the name of Lumiskin as a skin brightener/lightener that inhibits the body’s melanin production.  Another scavenger is spin trap, a molecule that stops free radicals from spinning out of control and causing damage to cells (it is a favorite of the Your Best Face line).

Fullersomes is another heavy hitter. Aka fullerenes, these are more effective nutrient carriers than lipsomes and nanosomes (thanks to being up to 10 million times smaller). However, there’s been some controversy about fullerenes in cosmetics as some believe they actually cause radical damage.

There are plenty of independent studies on aminoguanidine. It seems that it inhibits the cross-linking of proteins that cause signs of aging such as break down of elastin. One researcher concluded that “aminoguanidine improves wound heating, restores growth factor TGF-β1 expression, and preserves collagen ultra structure”. Another useful ingredient is a skin hydrator, cassia angustifolia. The polysaccharides (galactomannan) from this botanical mimic hyaluronic acid.

There are plenty of other actives to note, including EGCG, the active component in green tea, blueberry and superoxide dismutase. And making this even better value is that, aside from a smidge of silicone, there are no fillers.


Ingredients in Cosmedix Affirm

Hamamelis Virginiana (Witch Hazel) Water, Glycine Soja (Soybean) Protein, Aqua (Water), Peumus Boldus (D-boldine) Leaf Extract, Glycerin, Catalase, Cassia Angustifolia Seed Polysaccharide, Epigallocatechin Gallate (EGCG), D-alpha-tocopherol, Silicone, Heavy Water (Deuterium Oxide), Vitis Vinifera (Grape) Seed Extract, Resveratrol, Whey Protein, Thioredoxin, Xanthan Gum, Vaccinium Angustifolium (Blueberry) Fruit Extract, Glutathione (L), Superoxide Dismutase, D-beta-glucosamine, Aminoguanidine, Spin Trap (PBN), Fullersomes, Citrus Reticulata Leaf Oil, Santalum Album (Sandalwood) Oil, Benzyl Alcohol