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Avon Anew Clinical Derma-Full X3

Is a Solution for:
Sagging Skin
April 16, 2009 Reviewed by Marta 5 Comments
Posted by Marta

In a crowded world of barely differentiated potions and lotions, Avon has come up with something new. Anew Clinical Derma-Full X3 ($54), is injectable-grade derma filler in tube, not a syringe! And the nice people at Avon sent me two, so one of them is on offer for a reader to review.

Did you know that hyaluronic acid injections are the second most popular surgical or non-surgical procedure in the US? HA is the naturally occurring and widespread component found within the extra-cellular space within bodily tissues, especially those of the face. The stuff used for injected fillers used to be extracted from rooster combs, but is now produced as a reactive byproduct of a benign bacteria and is identical to the substance found within the skin. Its water-binding and water-attracting attributes fill up the spaces between the connective fibers collagen and elastin in the dermis, which together make up the structural totality of the extra-cellular matrix (ECM). When injected into the face, HA functions to hydrate and separate the skin, holding onto water and supporting all that makes the face plump and voluptuous.

As procedures go - and by now you know I am not a fan of them - this is one I would consider. A 2007 study by the University of Michigan strongly suggests that injectable fillers actually lead to the creation of new collagen. The study only used a particular brand of filler called Restylane (Restylane did not pay for the research) and only 11 volunteers aged 64 to 84 were involved. Still, the researchers seem pretty clear about having produced meaningful results. What seems to happen is that the injected filler stretches the fibroblast and tricks it into thinking it is still young and virile and so it produces more collagen.

So much for the background check, now back to Avon. Anew Clinical Derma-Full X3 has the same HA facial filler as that injected by dermatologists, although it is listed in the ingredients as plain old sodium hyaluronate. This has a smaller molecule size than HA and so should be able to better penetrate the skin. However, it is a very standard cosmetic ingredient. Not sure what purpose the blue helix thing has, but it looks pretty cool, I must say.

As well as HA, Avon has added in Matrixyl, a powerful antioxidant peptide. Thiodipropionic acid is also an antioxidant, although it is primarily used for preserving food and I couldn't find any evidence of its role in skin care. Trioxaundecanedoic acid is an oxa diacid and a form of retinoid that acts as an exfoliator. Phytol is a precursor to vitamin E and A and an antioxidant, while studies have demonstrated that fennel is an anti-inflammatory and antioxidant.

Avon claims that 82% of women who tried the cream in a trial and responded said they thought their cheeks looked more full and youthful. So if you'd like to compare notes with these women (and with me as I'll be trying it out too), then post a comment convincing us that you will come back to the community with an honest review and be sure to email us at with your shipping address and BE SURE to put Avon in the subject line.

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What is it: hyaluronic acid

What is it: matrixyl

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Water, glycerin, cyclopentasiloxane, propylene glycol, glycolic acid, thiodipropionic acid, trioxaundecanedioic acid, ethylhexyl salicylate, sodium hyaluronate, phytol, fennel extract, palmitoyl oligopeptide, palmitoyl tetrapeptide-7, PEG/PPG-18/18 dimethicone, dimethicone crosspolymer, butylene glycol, carbomer, ammonium hydroxide, caprylyl glycol, polysorbate 20, fragrance, phenoxyethanol, disodium EDTA, Mica/CI 77019, titanium dioxide/CI 77891, blue 1/CI 42090, Red 4/CI 14700.
  • January 31, 2010

    by ghania haddad

    I am 45 and never tryed any anti aging product before just ROC moisturiser, I don't drink and don't smoke,I would like to use this product .

  • May 21, 2009

    by Sue Coorey

    I am not asking for the sample as I am already using it and just ordered a second bottle! I just wanted to share my experience with you.I noticed a big difference overnight on the first application and am now on day 4. I can honestly say that having spent a small fortune on creams and potions and thinking Olay Regenerist was probably the best, so far Derma Full X3 has by far exeeded all expectations. I don't usually write into forums although I do often read them, but this product has made me want to shout out to every woman (and man!) out there who wants their skin to look like it did 10 years ago - get yourself a bottle! You won't regret it. If my skin feels and looks this good after 4 days then who knows what it will do in 4 weeks.

  • April 28, 2009

    by jul mcwhallan

    OMG i have been waiting to try this for weeks but just cannot afford at this time. I do product reviews for my friends all the time and they are awaiting the Avon the X3 overview. There seems to be varying results for this product and the only site that shows more than one or two reviews is Avon...which...well...I read with some reservations. anyway, send it to me and i will give you a play by play on daily usage, i have just finished a verbal review to friends for the Vitamin C serum at Avon (great for age spots on hands but has not done much for skin damage to face) so I am ready for a new challenge!

  • April 18, 2009

    by Karen

    I've had fabulous results from Restylane but it's, well, expensive, so I have been looking for alternatives. I'm a writer by trade and would happily review Avon's Anew, though frankly I still think of Avon as passe and for *cough* older women. (I guess that's me, now, yikes!) I'm glad to see Avon is getting a facelift too!

  • April 16, 2009

    by Justine

    I would love to try out Avon's Anew. I am still suffering from withdrawal after my too brief love affair with TNS. Sigh. $250 was a little beyond my budget.

    How's about having a mini Truth in Aging experiment? I take some before and after pics and readers can judge (blindly) if there is a difference. Might be fun. Although now I come to mention it, I might be a little nervous getting that up close and personal with everyone :)

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