Mark my words, sirtuin is going to be the new anti-ager that tout la America will be speaking about in 2009. Not least because it is the ingredient that Estee Lauder will be throwing its weight behind with two new potions, Time Zone Line and Wrinkle Reducing Moisturizer, to be launched in December in time for the holidays. For Truth In Aging readers who want to put the sirtuin hype to the test before then, I have a bottle of REN Sirtuin Phytohormone Replenishing Cream ($80) for a reader to review.

I posted a What Is It on sirtuin about month ago. The backstory is fascinating and worth a quick reprise. The main role of sirtuins is to regulate the activity of the genes responsible for metabolism, cell defense and reproduction. When food is scarce, the body's sirtuins go into self-preservation mode. Researchers discovered the role of sirtuins when trying to find out why mice live longer if you put them on a subsistence diet. Ever since, anti-aging potion makers have been trying to find things that will activate the sirtuins.

It seems that the magic ingredient in grape, resveratol, can do it and so can rice germ. REN has gone with the rice germ oil. In addition to activating the sirtuins, REN says it is also activating perlecans. These are proteins that cross-link across the surface of cells and, claims REN, prevent sagging skin. Phytohormones derived from wild yam are the perlecan activators.

This being REN, the product uses only natural ingredients (no PEGs, silicones, sulfates, parabens etc) and has packed a dizzying number of them in. Worth a call out are cranberry (an antioxidant with moderate levels of vitamin C), candle tree (an anti-fungal used for treating skin infections) and kudzu (an invasive plant that is full of flavenoids).

Before you post a comment to convince us that you are deserving and honest (when you say you will write a review, it means that you will write a review), please note that REN positions this product as being aimed at the pre and post menapausal.

Ingredients in REN Sirtuin

Rosa Damascena Flower Water, Butyrospermum Parkii (Shea) Butter, Caprylic/Capric Triglycerides (Source Coconut Oil), Cetearyl Octanoate (Source Palm Oil), Cetearyl Alcohol (Source Palm Oil), Oryza Sativa (Rice) Germ Oil, Myristyl Myristate (source Palm Oil), Oleyl Alcohol (source Palm Oil), Cetearyl Glucoside (source Corn), Glycerin (Source Coconut Oil), Camellia Oleifera Seed Oil, Triheptanoin (source Coconut Oil), Lauryl Laurate (Source Palm Oil), Dioscorea Villosa (Wild Yam) Root Extract, Glycine Soja (Soybean) Lipid, Vaccinium Vitis-Idaea (Lingonberry) Seed Oil, Palmitoyl Hydrolyzed Wheat Protein (source Palm Oil and Wheat), Oryzanol (source Rice), Calcium PCA, Dipalmitoyl Hydroxyproline (Source Amino Acid), Phenoxyethanol (Source Aromatic Ether), Vaccinium Macrocarpon (Cranberry) Seed Oil, Mannitol (source Sugar), Cyclodextrin (source Sugar), Faex (Yeast) Extract, Disodium Succinate (source Salt), Omega 6 Ceramide (source Carthame), Commiphora Myrrha Resin Extract, Laminaria Ochroleuca (Algae) Extract, Carbomer (source Polymer), Sodium Hyaluronate (source Wheat), Cassia Alata (Candle Tree) Leaf Extract, Inulin (source Wheat), Alpha Glucan Oligosaccharide (source Wheat), Pueraria Lobata (Kudzu) Symbiozome Extract, Sodium Hydroxymethyl Glycinate (source Amino Acids), Oryza Sativa (Rice) Extract, Hippophae Rhamnoides (Seabuckthorn) Berry Oil, Rosa Damascena Flower Oil, Citrus Aurantium Dulcis (Orange) Flower Oil, Citrus Grandis (Grapefruit) Peel Oil, Natural Fragrance (100%).