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Deciem NIOD Copper Amino Isolate Serum 1% Review

is a Solution for:
Dull Skin, Sagging Skin, Sensitive Skin
Deciem NIOD Copper Amino Isolate Serum 1%
April 4, 2016 Reviewed by Marta 7 Comments
TRU Rating
A collagen-boosting serum that works best with a moisturizer


Firms and tightens


Contains potential toxins

As members of the Truth In Aging community well know, one of my favorite ingredients is copper peptides. This ingredient is a powerful booster of collagen and restorer of hair with a long and rich research history going back to the 1970s. So Deciem’s NIOD Copper Amino Isolate Serum 1% ($60 in the shop) had me at hello.

The copper used here is a tripeptide, meaning that it has been combined with three amino acids. I was able to mentally reference the fact that in my Truth Vitality Advanced Complex for hair, the key active is copper with five amino acids. What makes NIOD’s face serum neat is that it packages the copper tripeptide-1 part of the formula separately and you mix it with what they call an activator, a copper salt from two more amino acids.

The 1% that Deciem boasts about is actually worth the hubris, as research has been conducted at 0.68% and produced results on inflammation. Talking of hubris, it is claimed that this serum will make you younger looking in only five days. I am not so sure I can concur with that, but after a month of testing it, I am convinced that it should be part of my regimen.

I didn't particularly notice wrinkle reduction as a result of my test. That may come later. But where NIOD seemed to really be helping was with firming, especially my lower cheeks and sides of my mouth going to the chin. This is where sagging tends to begin for me and I believe that the copper peptides (along with ultrasound and LED) made a difference.

NIOD Copper Amino Isolate Serum 1% really is a serum and does not for one minute pose as a moisturizer or even as a serum that can be used on its own. My slightly oily skin can often wear a serum without the need to layer a moisturizer, but not in this case. Despite the low-molecular version of sodium hyaluronate, this serum is very drying without an additional moisturizer.

One reason for this may be that it includes myristoyl nonapeptide-3, a peptide that is said to mimic retinol and exfoliate the skin in order to encourage cell turnover. There’s not much research on this ingredient that I can find. I was intrigued to see some decapeptides and an oligopeptide and discovered that along with wheat protein they are marketed as an ingredient called Renaissance Powder. The manufacturer promises it will regenerate the skin and minimize scars.

There are a couple of potential toxins amongst the preservatives and solvent that could be irritating. I had no adverse reactions. Overall, I would heartily recommend this to anyone wanting to introduce collagen-boosting copper into their skincare routine.

  • February 27, 2018

    by Dawn

    please recommend me an am and pm routine of niod products. I currently use cereve hydrating cleanser and I use thayers alcohol free witch hazel as a toner so need to know if I need to eliminate those? I also have 2 vitamin c serums, timeless c e feluric and truth treatments vitamin c very expensive and need to know where to add those into routine. I am 54 white worried about fine lines, age spots, getting loose and saggy around jowls, neck and skin above eye below brow, large pores, dry sensitive skin with some rosacea

  • July 24, 2017

    by Gail

    I am on my 2nd bottle of CAIS serum 1% . There is a firmness that I can tell. Unsure about the wrinkle effect.
    I am 63 years old. I have used many products. This one is a keeper. I am using the neck serum. have been using for 3 days
    along with retina. I have high expections about it too. thanks for all your research.

  • July 2, 2017

    by Marta

    Hi Cristina, retinols are best used alone and at night. However, if you must layer then retinol goes first, then wait 15 minutes before applying anything else

  • July 1, 2017

    by Cristina

    Love this serum and been using it for a good while. I really wanted to introduce retinols to my routine ( i am REALLY getting old ;) ) . Also wondering if that would just not interfere with the CAIS. Also, better to use retinols before or after it? Thank you

  • October 9, 2016

    by Marta

    Hi Shalini, glad to hear that you like this. You can certainly layer it under those other serums.

  • October 8, 2016

    by Shalini

    (5 out of 5)

    This far I'm loving using this serum. I feel it really balances my skin and it just feels healthier. I do want to understand however, if I can layer either the Rejuvel or the stemulation hi impact serum on top of this? Will the efficacy of the ingredients be negated by layering any products? Thank you!

  • April 18, 2016

    by Lorna


    Preksha recommended some products for me, which included a couple of Deciem products:-

    ~ NIOD Fractionated Eye-Contour Concentrate Serum (15ml), and
    ~ NIOD Copper Amino Isolate Serum 1.00% (30ml).

    The NIOD Copper Amino Isolate Serum 1.00% (30ml @ $60.00 in the TIA Shop) is also available in a 15ml bottle in the UK @ £38.00, or the full 30ml size @ £60.00.
    Aqua (Water), Sodium Hyaluronate Crosspolymer, Dimethyl Isosorbide, Ethoxydiglycol, Glycerin, Copper Tripeptide-1, Myristoyl Nonapeptide-3, Copper Lysinate/Prolinate, Zinc Palmitoyl Nonapeptide-14, Decapeptide-22, Ogliopeptide78, Palmitoyl Decapeptide-21, Methylglucoside Phosphate, Hydrolyzed Wheat Protein, PPG-26-Buteth-26, PEG-40 Hydrogenated Castor Oil, Pentylene Glycol, Ethylhexylglycerin, Xanthan Gum, Caprylyl Glycol, Glyceryl Caprylate, Phenylpropanol, Chlorphenesin, Phenoxyethanol.

    However, there is a NIOD Copper Amino Isolate Serum available in a 5% version in the UK too (15ml @ £130.00). The ingredients listed for this 5% Copper Amino Isolate Serum are as follows:-
    Glycerin, Copper Tripeptide-1, Aqua (Water), Methylglucoside Phosphate, Copper Lysinate/Prolinate, PPG-26-Buteth-26, PEG-40 Hydrogenated Castor Oil, Chlorphenesin, Phenoxyethanol.
    Aqua (Water), Sodium Hyaluronate Crosspolymer, Glycerin, Dimethyl Isosorbide, Ethoxydiglycol, Decapeptide-22, Ogliopeptide-78, Palmitoyl Decapeptide-21, Zinc Palmitoyl Nonapeptide-14, Myristoyl Nonapeptide-3, Hydrolyzed Wheat Protein, Pentylene Glycol, PPG-26-Buteth-26, PEG-40 Hydrogenated Castor Oil, Xanthan Gum, Caprylyl Glycol, Glyceryl Caprylate, Phenylpropanol, Ethylhexylglycerin, Chlorphenesin, Phenoxyethanol.

    Would you advise I started out with the NIOD 1% version, or should I risk the added power of the 5% Copper Amino Isolate Serum?

    I'd appreciate your advice!

    Many thanks,


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