The first problem I have with Dermapril-SP is that it isn't 100% clear that it contains matrixyl 3000, a powerful anti-oxidant that is the result of combining two peptides: palmitoyl oligopeptide and palmitoyl tetrapeptide-3. Dermapril's ingredients list has palmitoyl oligopeptide-7, but no tetrapeptide. Anyway, let's give it the benefit of the doubt.

And while I'm in such a generous frame of mind, I should note that there are plenty of other anti-oxidants in Dermapril-SP in the form of green and white tea, plus grape. There is argan oil and gotu kola, a plant extract that is an anti-inflammatory and a wound healer that restores type 1 collagen (it has been used in the past as a leprosy cure). So far, rather good.

However, the second problem I have with Dermapril is that there are no less than another 20 or so ingredients that are padding (in the form of silicones), emulsifiers and other such things that go into making creams, and preservatives.

Mychelle Supreme Polypeptide's ($40 for 2.2oz) ingredients, on the other hand, are almost all there to do some good. Plus there is really nothing that will do evil. Matrixyl 3000 is the fourth most dominant ingredient. Then there are moisturizers and vitamin E, plus another peptide (from marine extracts). There are anti-oxidant green tea, wine and carrot. There is also some retinol. Plus phospholipids and sphingolipids (the essential molecules in cellular membranes). The preservatives are totarol, a naturally occurring (in plants) anti-bacterial and sodium hydroxymethylglycinate, which is not an irritant.

At some point in the near future I'll compile a Five Best matrixyl 3000 creams round up. To avoid suspense, I can tell you that Mychelle will make it in, Dermapril will not.

UPDATE 2/3/2008: Mychelle Supreme no longer uses matrixyl. Mychelle said it didn't meet standards of hygiene. You can read about the new formulation here.