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Estrogen applied topically and benefits for skin

August 16, 2011 Reviewed by Marta 25 Comments

At the urging of Arandjel, I decided to take a look at estrogen as an anti-aging skin care ingredient. I’m confining my research to topical estrogen and what its positive effects – if any -- might be. For those interested in the broader topic of hormone replacement therapies, there’s a discussion thread led by Susan after my post on the Second Half of Your Life. Here I want to try to work out if the good imparted by topical estrogen outweighs the possible risks.

Estrogen and Skincare

The general theory is that postmenopausal women on estrogen replacement therapy develop fewer wrinkles and have better skin texture and elasticity than those not taking estrogen. So, it seems logical that topical application of estrogen should also be helpful. There are two ways to do this. One is with a topical estradiol or estriol cream. The other is with phytoestrogens, plant-derived ingredients that mimic human estrogens.

Does Estrogen Improve Skin?

Estradiol and estriol are typically used in gels to treat vaginal dryness in post menopausal women. As far as their success with dry, wrinkled skin is concerned there is one much-quoted study from the University of Vienna Medical School, Austria. The trial was conducted with 0.01% estradiol or 0.3% estriol on 59 postmenopausal women. After six months of treatment, a marked improvement in skin elasticity and firmness was noted; wrinkle depth and pore size decreased by over 60% in both estradiol and estriol groups. Skin moisture and collagen synthesis increased significantly.

However, other studies have not been so positive and in 2009, dermatologist Margaret E. Parsons, MD, FAAD from the University of California reviewed them and concluded that at best the results where mixed as to whether estrogen improves the appearance of the skin.

“Based on the research conducted thus far, it does not appear that topical or oral estrogens are a viable long-term solution for improving sun-damaged or aging skin,” said Dr. Parsons. “In my practice, I do not prescribe estrogens for skin rejuvenation because of the lack of consistent data to support their use and the known risks of prolonged estrogen therapy – including an increased risk of breast cancer.”

For example, one study examined whether low-dose hormone therapy improved aging skin in 485 women who were on average five years post-menopausal. The study concluded that estrogen supplementation did not provide any significant improvement in sun-damaged skin.

Could Other Factors Influence Estrogen's Effectiveness for Skin?

Timing might be a factor. In one study, using Premarin cream, researchers observed a trend, although not statistically significant, of improvement in the skin of women who were less than 24 months postmenopausal. Two other studies concluded that the use of topical estrogens, such as Premarin cream or topical estradiol gel, could decrease fine wrinkling, improve roughness of the skin and stimulate collagen synthesis. Yet another found local that estriol, when applied to abdominal skin for three weeks, thickened fibers in the papillary dermis of patients.

Alternatives to Estrogen for Skincare

Phytoestrogens are another option. They tend to appear in anti-aging creams as plant derivatives such as black cohosh or isoflavonoids derived from soy. It turns out that black cohosh may not even be a phytoestrogen. Soy isoflavones, on the other hand, are a class of estrogen-like compounds, specifically genistein and daidzein. There are a few studies that suggest that soy is promising.  In 2004, European researchers found that soy extract resulted in increased collagen and HA synthesis and “appears to rejuvenate the structure of mature skin”.

Estrogen and Acne

But some dermatologists are not convinced. Acne (of the post menopausal varieties) is one of the skin conditions that estrogen is supposed to help with. Decline of estrogen can leave testosterone unopposed and this can increase sebum activity leading to acne. However, Diane Thiboutot, M.D at Penn State Hershey College of Medicine the concentration of estrogen needed to decrease sebum production would need to be very high. If there were high doses of topical estrogens, they might be able to reduce sebum production and offset the effects of androgen and the development of acne, but there would be concerns about systemic side effects."

Concerns About Estrogen

How likely are those systemic effects? Dr Leslie Baumann cites a trial by Kainz et al on 17 women for three months with a topical that suggested no systemic effects and estrogen may, therefore, she concludes be useful for aging skin. Nonetheless, she urges extreme caution and treatment of a small area only by post-menopausal women.

Another part of the concern about estrogens in cosmetics is that they are there "by stealth" as ingredients that mimic human estrogen (albeit usually weakly), such as parabens and they have been controversially been linked to cancer. Some of these ingredients and the types of concerns are in my post Estrogen In My Shampoo and Copley’s Estrogen In My Face Cream.

The way I feel about topical estrogen is that there may be risk of cancer. Certainly more research is needed on this area. In the meantime, the evidence of benefits of topical estrogen hasn’t convinced me to take that risk with a hormone gel. Would that mean I would ditch a cream that had soy or black cohosh in it? No, not yet. When I looked at soy in some detail, it seemed to me that there wasn't a very robust link to cancer in studies done so far and the amounts in cosmetic formulations are relatively small. On the other hand, they don't really convince me as skin rejuvenators so I won't be going out of my way to use them either.

  • June 2, 2018

    by Traci

    I'm pretty sure that estriol can't convert to estradiol or estrone so I wouldn't worry about topicals that contain only estriol. I was taking DHEA for hot flashes and night sweats and it worked great until I started breaking out like I was a teenager. I didn't lose my hair or grow a mustache but the acne was horrible so now I'm using Emerita estriol on my face and stopped the DHEA. My face already looks better after three days. :)

  • April 26, 2018

    by Crystal

    I use a very good brand of Estradiol / Estriol cream by LIFE FLO bought on Amazon, cheaper than health food store. Comes in a pump. Ive been using for a couple years now. It saved my life! It completely removed my depression and brain fog. Its about 25.00. I use for HRT on insides of my arm and chest and leg area. Due to a complete surgically hysterectomy I had at age 40. I used oral estrogen for a while , about 5 years right after surgery, I still looked SO YOUTHFUL. Until I stopped oral estrogen, Then the wrinkles appeared big time!! Do NOT use Premarin, its from horse urine. But I might start using what I have on my face to test and see!

  • March 20, 2018

    by Rebecca

    I've been using a millimeter of Premarin every day for the last five months on the skin around my mouth. Perhaps it's my imagination, but I think the fine lines have have become less obvious. I'm going to continue for the next seven months, a year total, and then decide.

  • January 10, 2018

    by Helen

    For anyone using Premarin, (the name is derived from 'pregnant mare') please know it is made from the urine of pregnant horses. The hormone is extracted from the urine. so as to increase the amount of hormone in the urine, the horse is kept confined and in a constant state of thirst. its cruel and there are plant-based alternatives that deliver the same result.

  • December 29, 2017

    by Tressie

    Nice post! This is a very interesting and informative article. I was not knowing that Estrogen therapy is of this much importance. Can PCOD cause wrinkles? I've heard that women with PCOD can face acne problem, can it result in early aging problem also?

  • November 27, 2017

    by Andrea Smith-Wilson

    I have been using Premarin under my eyes and above my lip generously for a few weeks and the face looks great. I am 54 years old and still taking a low dose of estrogen contraceptive pill. I also take hormone balancing supplements. BUT I am very sportive and buff and all of a sudden a see a steady weight increase on my scale and I work out twice a day and eat very consciously. So how does this weight gain come to pass? I am suspecting the extra estrogen I put on my face. Does anybody have any experience or ideas? Please share!! I need some info, doing research......

  • November 24, 2017

    by Laramie

    Hello, thank you for this post. It is an excellent topic of discussion. I just wanted to warn that this treatment may increase your risk of dark spots as it did for me. After using .01% natural estrogen cream on my face every morning for three months I developed dark spots under my eyes and the center of my forehead. I went to a dermatologist who is now treating me with a prescription skin bleaching regimen. He said that the sudden onset of the dark spots he guessed were hormone related. I fessed up about using the estrogen treatment on my face and his jaw dropped. So, warning to people with olive complexions.... It may not be worth it.

  • February 28, 2017

    by Suzanne

    What does Dr. Pardon recommend for skin rejuvenation, if not w/estrogen?

  • June 13, 2015

    by margaret

    Where do you buy the face cream and the exact name and strength

  • February 16, 2015

    by ClIre

    Hi - I'm interested to hear what exactly Julie is using to mix her cream for face and eyes. I am also keen to use something on my lips because I have just started noticing little lines above and below my lips and they are looking not as full as they were! Was thinking of using Premarin bu not sure! Any advice?

  • January 20, 2015

    by sherri

    Julie, I would love to know more details about the cream you are using. My Dr. has prescribed an estriol face cream, but my skin is so sensitive almost all bases irritate it. I would love to make my own cream where I can have control over all ingredients. What pharmacy do you use to purchase the estrogen for your cream? What peptides and other actives do you use? Any specifics you can give would be so appreciated!

  • January 16, 2015

    by Julie

    My dermatologist used to sell me an eye cream that he said was .05% estrogen, that he compounded himself, to improve the look of my lids (decrease lines, etc.). This was around 2004.

    It seemed to work, but I didn't like the $50/ half-ounce price tag, so I bought some of the weak estrogen online myself from a pharmacy, and started mixing my own, also resulting at .05% (same as my dermatologist's). I also add other actives (peptides, etc.) I've been doing this for over 10 years now. (So, counting the actives, the credit may not all be the estrogen's.)

    I've also been taking low-dose BC pills, but will phase those out since my blood pressure has raised somewhat - possibly just normal aging. Previously, I usually had low blood pressure.

    I'm 55, have very few lines, and great skin tone. My skin isn't blotched - but I also use sunscreen regularly (since age 20), and self-exfoliate with over-the-counter 10% alpha-hydroxy about once a week. Maybe less often.

    I stopped using Retin-A type exfoliants in my 30s, since I felt it thinned my skin too much.

    People often don't believe me when I tell them my age. They usually think I'm at least 10 years younger, usually even younger. My mom was always youthful, but I know my skin is in better shape now than hers was at her age. She was on Premarin at my age. I'm not a fan of that stuff, for numerous reasons.

    I made a similar cream as mine for my husband, sans estrogen - his skin improved quite a lot over the course of a few months. Lots of his friends who haven't seen him in awhile can't get over how much better he looks now.

  • September 9, 2014

    by Denise

    I feel in many ways, some of the info posted here is a disservice to women who could be using a whole safe estrogen to relieve low E symptoms and preserve their facial skin with little to no systemic effects (when using estriol in the facial skin). Please read the French longterm clinical study and the studies attached to the bottom of link two.

  • August 25, 2013

    by Kim

    I have been using a bioidentical USP estriol cream (over-the-counter) for about a year now. I do see positive results with every other day use on my face and neck. The biggest positive result is the decrease of those horizontal neck lines and sagging. Also, estriol USP is SAFE! It is a weak estrogen, and research shows it not only does NOT increase your risk of breast cancer, but research shows it actually may help protect you from breast cancer. Do the research online if you don't believe me. :)

  • January 3, 2013

    by Michele Watson

    Hi Marta
    Any updates on this thread? Always interested in this as I am postmenopausal (52)and still not on on HRT but symptom free with few wrinkles. Still I am interested in maintenance. This past year I have noticed a definite loss of elasticity in my body-especially funny enough,my upper arms and neck area.

  • October 18, 2012

    by Ken G. Knott, M.D.

    Thank you for your comments in regard to using low density estradiol or estriol creams to treat aging skin. Would you mind advising about the authentic studies that have proven a connection of bio-identical estrogens and breast cancer? Are you repeating what you have heard, like most well meaning people or do you have hard evidence that I've not seen? Either way, I would appreciate getting to the truth of the matter. Please don't quote the WHI study as you are aware the study was about the effects of a patent medicine and not bio identicals.

    Thank you,
    Dr. Knott

  • August 19, 2011

    by Kira

    I read books by Susanne Somers on this subject, as well as listened to many physician interviews. So far - I am convinced of the benefits of BHRT. The key is proper regular testing and monitoring the hormonal level, and tweaking the regimen as needed. There is no one single dose safe and effective for every woman, it is highly contextual.

  • August 18, 2011

    by Marta

    Hi Lina, thank you for contributing. I couldn't agree more about the whole area of hormones being something we need to be more educated on.

  • August 18, 2011

    by LIna Jacobson

    Bear with this long post. Please refer to Dr. Neal Rouzier, He has been teaching other physicians and prescribing bio-identical hormones for 18 years. If you're interested I'll share my osteoporosis story at another time, for me nothing short of miraculous.But the topic here is wrinkles. Let me first refer to the use of estrogen and progesterone.
    "Estradiol and progesterone demonstrated no increased risk of breast cancer. Synthetic estrogen (Premarin) and synthetic progestins (medroxyprogesterone and noresterone) all dramatically increased the risk of breast cancer. This was a ten year study of over 100,000 women, the largest and longest study to date comparing natural hormones to synthetic hormones". Breast Cancer Res Treat 2007:101:125-134 pg.225 "How to Achieve Healthy Aging", Neal Rouzier, M.D.
    The real anti-aging hormone is testosterone, not just for men. "The benefits can produce improvement in well being, energy, body composition, bone density, and sexual function. Testosterone has many health benefits in preventing skin wrinkles and skin thinning from loss of collagen. Testosterone protects against deterioration of muscle, ligaments, joints, tendons, bone and skin-anything that has to do with our structure and aesthetics."
    So bottom line, lets get educated about this important issue for our health and then see what incredible anti-aging benefits appear.Demand that your doctors become educated themselves, there is over 40 years of science to back up these claims. You deserve great health and great beauty.

  • August 18, 2011

    by Arandjel

    Sorry to hear about your bad experience, Faye. The hyperpigmentation aside, which is fairly common for estrogen, did you notice any improvements? And what made you try it in the first place? I had a look at the tri-estrogen cream, and it appears to be extremely potent; just like you mentioned, it's not intended for the face. Then again, there was that woman on the Oprah show who had used Premarin on her face for decades without any harm. We are all so different. I do hope you get that hyperpigmentation sorted out: what's your skin care regimen like now?

  • August 17, 2011

    by Faye

    Ciao, A couple of years ago, I tried some tri-estrogen cream (though not intended for the face) one side of my face for a few months...stopped immediately when I noticed lots of hyperpigmentation! Not nice--I'm still dealing with it.

  • August 17, 2011

    by Julie Kay

    Hi Marta, and thanks for this article! I take HRT (Premarin) and have done for a number of years (a decade, more)- the lowest dosage and that cut in half. I had issue with estrogen dominance a few years back and began using progesteron cream to combat this. It was during this time that I began halving my estrogen tabs. I no longer feel the need to take or use progesteron. My point, yes, I have one HA! is that the whole HRT is a tricky business all by itself without worrying or thinking if it can help w wrinkles. If it's a side benefit, great, but it really shouldn't be the focus. In my opinion. ~jk

  • August 17, 2011

    by Marta

    Well thanks for the idea in the first place! I didn't come across a single study that included men. But I am guessing its a moot point because as men age their testosterone declines and estrogen increases - the exact opposite of women.

  • August 17, 2011

    by Arandjel

    Thank you, Marta, for yet another well-researched article. :) I wonder, though, how this all applies to men. In one study I came across, done on both sexes, the results were equally successful in treating aging skin. And as I understand it, there are no risks of developing female features, being that the concetratíon of estrogen and its derivatives, at least in OTC creams, isn't high enough to penetrate into the blood stream. But then who really knows with so few studies conducted on the subject matter...

  • August 16, 2011

    by Evening Feeding: Mother Of 13-Year-Old Who Smashed Up Shop In London Riots Blames Government | Mommyish

    [...] Estrogen applied topically benefits skin (Truth In Aging) [...]

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