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Five Best anti-aging products with teprenone

osmotics renovage
Is a Solution for:
Sagging Skin
September 15, 2010 Reviewed by Marta 16 Comments

Telomeres were recently popularized – and legitimized – by a Nobel Prize winning team of scientists. Research on telomeres and aging has led to an ingredient called teprenone (sometimes marketed under the name of Renovage) cropping up in anti-aging products, potions and lotions.

Telomeres shorten every time a cell divides. When they become very short, they trigger cell crisis and cell death. In cosmetics, the objective not to lengthen the teleomeres, stabilize them so that at least they won’t shorten. Maintaining telomere length extends, we are told, the Hayflick Limit by one third. Renovage (made by the people behind Matrixyl) aims to do just that.

Here’s a round up of the Five Best anti-aging products that feature Renovage/teprenone. I should qualify this by saying that these are the best that we’ve tried out so far. I hope that this list will updated as we find even better – feel free to make suggestions.

Osmotics Renovage Cellular Eye Repair Cream ($78) This has another ingredient that may help extend the hayflick limit, carnosine. What makes it stand apart from other antioxidants is its potential ability to fight against, not just oxidative damage done by free radicals, but also damage done by sugar-related glycation. There are plenty of independent studies on  another ingredient here, aminoguanidine. It seems that it inhibits the cross-linking of proteins that cause signs of aging such as break down of elastin. Resveratol has been isolated from polygonum cuspidatum root extract, also known as Japanese knotweed.

Your Best Face Correct ($150 in the TIA shop). The reformulation of what I found to be an excellent eye cream included teprenone and also some of the latest heavy hitters known to cosmeceuticals such as the antioxidant lipochroman-6 and collagen building Syn-Tacks. The fascinating spin trap, a molecule that catches free radicals is sill included, as is Matrixyl 3000. Firmer skin, reduced crepiness, diminished lines as well as help for chronic dark circles have all been reported by testers. Your Best Face also added teprenone to its face cream Boost.

CSI Telomere Fine Line Repair Cream ($31.75). This little guy is very similar to another teprenone cream that costs $100. A simple formula with three good skin hydrators: squalane, hyaluronic acid and xylitylglucoside anhydroxylitol xylitol. Sure there’s a few fillers, but you can’t quibble at the price.

Jack Black Protein Booster Skin Serum ($60). Launched a year or so ago,  this covers all bases. In addition to teprenone and heavy hitters such as Matrixyl 3000. There are omegas, green tea and vitamins A, C and E.  Some of the botanicals are organic, although not sorghum bicolor stalk juice, interesting ingredient that you’ll be hard pressed to find in the mainstream and which is known to tighten the skin. In the mostly mediocre men’s skincare market, this serum is a standout.

Skinn Wrinkle Balm Night Treatment ($40). This comes in two versions. The dry-normal version starts with olive butter, shea butter, sweet almond butter, and soybean sterols, normal-combination lists lavender extract, sunflower seed extract, shea butter, and squalane as its most populous components. The overall picture of each is uniquely quite nice, with interesting inclusions like barley, wild yam, green bean, tomato, and noni extracts in one (dry-normal), and more mainstream botanicals, such as sandalwood, algae, rapeseed, thyme, and aloe, in the other (normal-combo).

Ingredients in Skinn Wrinkle Balm Night Treatment (dry/normal)

Olea europaea (olive butter), butyrospermum parkii (shea butter), prunus amygdalus dulcis (sweet almond butter), glycine soja (soybean) sterols, santalum album (sandalwood) wood extract, phellodendron amurense bark extract, hordeum distichon (barley) extract, caprylic/capric triglyceride and teprenone (Renovage™), bisabolol, dioscorea villosa (wild yam) root extract, C12-15 alkyl benzoate and tribehenin and ceramide 2 and PEG-10 rapeseed sterol and palmitoyl oligopeptide (Dermaxyl™), caprylic/capric triglyceride and spilanthes acmella flower extract (Gatuline Intense™), phaseolus lunatus (green bean) extract, solanum lycopersicum (tomato) extract, lavandula spica (lavender) flower oil, superoxide dismutase, thioctic acid, linoleic acid, tetrahexyldecyl ascorbate, morinda citrifolia (noni) seed oil, tocopherol acetate (vitamin E)

Ingredients in Osmotics Renovage

Purified Water, Cyclomethicone, Butyrospermum Parkii Seed (Shea) Butter, Caprylic/Capric Tryglyceride, Squalane, Teprenone, Butylene Glycol, Aminoguanidine, Decarboxy Carnosine HCL, Peumus Boldus Leaf Extract, Polygonum Cuspidatum Root Extract, Spilanthes Acmella Flower Extract, Saccharide Isomerate, Cetyl Alcohol, Stearic Acid, Glycerol Stearate, PDG-100 Stearate, Ubiquinone, Vitis Vinifera (Grape) Seed Oil, Tocopheryl Acetate (Vitamin E), Dimethicone, Zea Mays (Corn) Oil, Retinyl Palmitate, Cholecalcipherol, Oenothera Biennis (Evening Primrose) Oil, Ascorbic Acid (Vitamin C), Carbomer, Titanium Dioxide, Disodium EDTA, Diazolidinyl Urea, Iodopropynyl Butylcarbamate, Tromethamine, Phenoxyethanol.

Ingredients in  YBF Correct

Reverse osmosis water, Eyeseryl (water, acetyl tetrapeptide-5), licorice root extract, Haloxyl (hydroxysuccinimide, chyrsin, palmitoyl oligopeptide, palmitoyl tetrapeptide-3), Snap-8 (water, acetyl octapeptide-3), olivem (cetearyl olivate), Matrixyl 3000 (glycerin, butylene glycol, water, carbomer, polysorbate-20, palmitoyl oligopeptide, palmitoyl tetrapeptide-3), cucumber extract, Renovage (triglyceride, teprenone), nylon-12, triglyceride, Syn-Tacks (glycerin, palmitoyl dipeptide-5, diaminobutyroyl hydroxythreonine, palmitoyl dipeptide-5 diaminohydroxybutyrate),alpha arbutin, nutmeg butter, caffeine, olive leaf extract, vitamin e, ethyhexyl palmitate, vitamin B5, dimethyl isosorbide, spin trap (phenyl butyl nitrone), Lipochroman-6 (dimethylmethoxy chromanol), Sepilift DPHP (dipalmitoyl hydroxyproline), idebenone, alpha lipoic acid, sodium hyaluronate, c10-30 alkyl acrylate crosspolymer, violet leaf absolute, oakmoss absolute, triethanolamine, paraben du.

Ingredients in CSI

Purified water, squalane, hyaluronic acid, caprillic/capric triglyceride, teprenone, polyacrylate 13, polyisobutene, polysorbate 20, xylitylglucoside, anhydroxylitol, xylitol, phenoxyethanol and ethylhexylglycerin.

Ingredients in Jack Black

Water, Glycerin, Sodium Polystyrene Sulfonate, Caprylic/Capric Triglyceride, 1, Sorghum Bicolor Stalk Juice, Palmitoyl Oligopeptide, Palmitoyl Tetrapeptide-7, Teprenone, Dipeptide Diaminobutyroyl, Linum Usitatissimum (Linseed) Seed Oil*, Camellia Sinensis (Green Tea) Leaf Extract*, Plantago Lanceolata Leaf Extract**, Sodium Hyaluronate (L), Taurine, Tocopherol (D-alpha), Retinyl Palmitate, Ascorbyl Palmitate (L), Simmondsia Chinensis (Jojoba) Seed Oil*, Aloe Barbadensis Leaf Juice*, Pelargonium Graveolens (Geranium) Flower Oil, Anthemis Nobilis (Chamomile) Flower Extract, Rosmarinus Officinalis (Rosemary) Leaf Oil, Lonicera Caprifolium (Honeysuckle) Flower Extract, Lonicera Japonica (Honeysuckle) Flower Extract, Cocos Nucifera (Coconut) Oil*, Zea Mays (Corn) Oil, Glycine Soja (Soybean) Oil, Citric Acid, Hamamelis Virginiana (Witch Hazel) Water, Xanthan Gum, Potassium Sorbate, Butylene Glycol, Carbomer, Polysorbate 20, Benzylamide Diacetate, Caprylyl Glycol, Phenoxyethanol. *Certified Organic.

  • January 14, 2016

    by Marta

    Hi Mike, welcome to the Truth In Aging community. You can browse our shop and our samples section:

  • January 13, 2016

    by Michael

    I am new to this site and am interested in anti wrinkle and under eye care. Can you tell me how I can try a few samples of some of these products. I am 60 yrs old and need some help with a more natural safe products. Thank you, Mike

  • November 3, 2010

    by Charlotte

    Thank you for your amazingly informative posts! I wanted to find a product that contains Teprenone, but not any of the fillers (PEGs, parabens,phenoxyethenol, sulfates etc.) that are typically in cosmetic products. Do you have any suggestions?

  • September 16, 2010

    by Julie Kay

    Isanna- I use Dermalogica AGE Smart Super Rich Repair at night now in place of Skinn's night cream. I also like their AGE Smart Antioxidant Toner. ~jk

  • September 16, 2010

    by Susan

    YBF's Correct is the very best eye cream period. I didn't use it for a 6-month period, and I saw the skin beneath my eyes turn crepey. I been using it again for about two months and the crepiness is gone. Cheers to YBF!

  • September 16, 2010

    by Pam Robbins

    Marta, Isn't Teprenone a chemical used in Japan to treat gastric ulcers?!?!?

  • September 16, 2010

    by marta

    You can buy Skinn products from their website

  • September 16, 2010

    by colinmack

    Where can I get the Skinn products? I don't see a link. I really want to try it!!

  • September 15, 2010

    by Susan Dent

    Hi Ines,

    After much reading about Correct here at TIA, and Darrell sending me a few samples, I decided to buy the full size from The Skincare Shop. When I received my package, I found they had ALSO sent me a full size trial version!

    This was very generous of them, but perhaps more than I really need - so would you like to try my full size trial one?

  • September 15, 2010

    by Isanna

    what Dermalogica products are using? I bought shaving kit for my brother after reading Marta's review and he loved it.

  • September 15, 2010

    by Darrell Owens

    Hi Ines,
    We have some new things in the works that you might like and we'll continue to offer complimentary trials and samples of Correct as often as we can - stay tuned! :-)


  • September 15, 2010

    by Ines

    As Julie I am a big fan of Skinn Anti wrinkle balm. I use the normal/combo and next morning my skin is soft and hydrated. I only wish that Correct will come with a trial size for those who, like me, cant afford the full size.:)

  • September 15, 2010

    by Julie Kay

    Marta, you have to know I'm smiling here! I use Skinn's normal/combination Night (or did before Dermalogica) and found it was a wonderful product. I'm happy to see it in a Five Best. Readers beware: the dry is for very dry skin and Skinn suggests you use normal/combo first than gently pat the dry/normal atop to cap it off as a extra needed boost for that extra dry skin. I've never been that dry myself. ~jk

  • September 15, 2010

    by Mark

    I, too, always look forward to the "Five Best" lists. Thanks for asking, Junko.

  • September 15, 2010

    by marta

    Good call Junko. Its high time we surfaced the very best antiaging ingredients. I also want to research how well some of these things are absorbed.

  • September 15, 2010

    by Junko

    I'm a big fan of the Best Five's as I'm sure everyone else is too! Marta, kindly consider a best five antioxidant's as my heads starting o spin over this one with so many saying that they're thousands of times better than what used to be the standard of Vitamin C and the likes. While I'm asking...maybe it's been updated but I'm not finding it, an update to the Five Best anti-aging ingredients to look out for (last one I'm seeing is Feb. 2009)??? Thanks for

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