I got some useful feedback about Truth In Aging the other day. A reader said "I'm confused, you keep coming up with interesting new serums and what not. Now I just don't know which one to try." We agreed that a helpful course of action would be to regularly update the Five Best (serums, moisturizers, eye creams, whatevers) to see if any of the new ones are good enough to topple anything from the previous list. So here we have an updated Truth In Aging's Five Best anti-aging serums.

First, a quick reminder of the last line-up (you can click here to read the entire January post): Image Skincare's Ageless Total Anti-Aging Serum; Tracie Martyn's Firming Serum; Boots No7 Restore & Renew Serum; Alaur Rederma Cellular Energizing Serum; Stella McCartney's Radiance & Youth Elixir.

A couple of new discoveries are creating some stiff competition for Five Best and after some careful thought and weighing the three key criteria - my experience, reader experience and clinical evidence (where it exists) - two of January's Five Best have been ousted.

So, here are Truth In Aging's Five Best anti-aging serums:

Image Skincare's Ageless Total Anti-Aging Serum. I started using this last August and I am now getting close to investing in a second bottle. The fact that I will do so without hesitation is endorsement in itself. I truly think my skin looks supple and healthy as a result of using it. It contains two key things: acid (glycolic and lactic) and the matrixyl peptide that is a very good anti-oxidant. Plus there's lots of plant extracts and soothing arnica.

Boots No7 Restore & Renew Serum. This just has to stay on as a Five Best for three reasons: it is just such good value at $22 or thereabouts; I have used it with good results and know others who have too; there is a clinical trial that was independent and demonstrated that the results are almost as good as with prescription tretinoin (retin).

Remergent DNA Repair Formula Age Retaliator Serum. This is a newcomer to Five Best. I've been trying this out for a couple of weeks and think it would make a good alternative to Image Skincare's Ageless. The key ingredient is an enzyme extracted from plankton that is supposed to repair DNA. Otherwise the ingredients are pretty similar - plant extracts and AHAs, but with a different anti-oxidant, ergothioneine. It is light and pleasant to use.

Zelens Radical Defence Serum It has been reformulated without fullerenes C60 but still has some powerful ingredients including, for example, retinol and dimethylmethoxy chromanol, synthetic vitamin E (also used in Elizabeth Arden's Prevage). Zelens also contains Arguireline (acetyl hexapeptide-8), which I consider to be a waste of time since all it does is superficially, temporarily and not very effectively inhibit muscle movement. AH8 (or AH3 or Argireline) is the key ingredient in StriVectin, Freeze 24:7, Avetone and Athena 7 Minute Lift. The packaging is pretty sexy.

Tracie Martyn Firming Serum. Although I've moved on to Image Skincare and like Remergent and Zelens, this stays on the list because I was happy with it for a number of years and it doesn't have anything nasty in the way of preservatives or silicones. I just received an email from someone who has just started using it and she finds it greasy and unpleasant. It will be interesting to see if it survives the next Truth In Aging Five Best revision.