It's hard to believe that the last time I posted Five Best anti-aging serums was in April. Since then we have made such good finds that it restores my faith in the cosmetic industry. In a sea of department store crap, there are some real islands of excellence.

Although Image Skincare remains a favorite of mine, there are some new contenders that are so powerful that they have ousted three of the former Five Bests. Gone are Osmotics (I was allergic to it, however, I must admit that I gave it to a friend who has great results with it) Tracie Martyn Firming Serum, Mychelle Supreme (the new version doesn't have matrixyl 3000 and the performance was poor in my experience), and Remergent DNA Repair.

And now a small drumroll for the latest Five Best anti-aging serums that actually live up to the name:

Image Skincare's Ageless Total Anti-Aging Serum ($40).I think I've been using this for the last two years for about five days a week. I supplement it with other collagen and cell-building serums (such as Reluma) because I think that Ageless is primarily a gentle but effective glycolic acid. It is brilliant at keeping the surface of the skin plump and bright. This is due to three acids - glycolic, lactic and malic - and hyaluronate. And it does have alpha lipoic acid, a good anti-ager. A little goes a long way - not only is this well priced, it can be eked out for nearly a year. The only problem is that it is not that easy to find so I'll have to direct you to my estheticianIdli Pekar.

Reluma Skin Illuminating Anti-aging serum ($130). This works at fading wrinkles and encouraging new growth. I like it so much that I'll be buying a second bottle (always the litmus test). The mercifully simple list of ingredients contains one that is extremely complex. The active in ReLuma, which is made by Invitra Cosmeceuticals from where you can buy direct, is human fibroblast conditioned media. In all, ReLuma has nine different human cytokines in the human fibroblast conditioned media.

Nutra-Lift Rejuvenating Therapy ($40). This well-priced product puts a lot of those $100-plus creams to shame. In addition to matrixyl 3000, this is choca with most of the anti-aging ingredients known to man. The collagen and elastin are from fish, so that should mean there's no danger of estrogen (as there is if they have been derived from human or other animal cells). Also included is astaxanthin, which is supposed to be 100-500 times more powerful as an antioxidant than vitamin E. Pycogenol is another antioxidant from the bark of the French maritime pine tree. I'm using it right now and the results on fine lines are very good.

Circadia's Myo-Cyte Rx Serum ($150). I won't pretend that it isn't on the pricy side, but this really works. As soon as I finished the tiny sample bottle (which was enough to fade a few lines pretty dramatically), I immediately forked out $150. Myo-Cyte has Matrixyl 3000, carnosine (which extends the Hayflick Limit - the number of times a cell can reproduce itself) and threonine, which helps keep connective tissues and muscles throughout the body strong and elastic.

Your Best Face Control($160). Control has YBF's signature ingredient, spin trap. This is a clever little molecule that seeks out free radicals that are spinning out of control and sets them right before they can do damage. While spin trap is going after free radicals, Matrixyl 3000 is promoting collagen growth, assisted by idebenone (CoQ10), another antioxidant with a good pedigree, and vitamins C and E. YBF can be bought in the TIA Shop.

Ingredients in Nutra-Lift Rejuvenating Therapy

Certified Organic Aloe Vera Gel, Matrixyl 3000 at 5% (Palmitoyl Oligopeptide, Palmitoyl Tetrapeptide-7 PAL KTTKS), Vitamin C ester, sea kelp / algae, liposomes, astraxanthin, grape seed extract, cetyl esters, nikkomulese, co-Q10, pycogenol, natural mixed tocopherals (vitamin e), anti-oxidant complex 14, natural firming complex (dmae, alpha lipoic acid) fruit flower complex 12, herbal complex 30, plant derived polysorbate 20, hydroxyethyl-cellulose, hyaluronic acid, copper peptide, marine collagen, marine elastine, organic royal jelly, Mexican yam, green tea, milk thistle, retinyl palmitate, ( vitamin A) ppgsmdi co-polymer., l-tyrosine, zinc sulfate, squalene, colloidal minerals.

Ingredients in ReLuma Skin Illuminating Anti-Aging Serum

Human Fibroblast Conditioned Media, deionized water, gycerin, sodium PCA,
allantoin, panthenol, cellulose gum, DMDM hydantoin, iodopropynyl butylcarbamate

Ingredients in Circadia Myo-Cyte

Water, Hyaluronic Acid, Acetyl Hexapeptide, Palmitoyl Pentapeptide, Palmitoyl Tetrapeptide, Ethoxydiglycol, Tretrasodium EDTA, Passion Flower Extract, Rosemary Extract, Chamomile Extract, Magnesium Ascorbyl Phosphate, Amino Acid Complex (L-Carnosine, L-Threonine, L-Glycine), Propylene Glycol, Diazolidinyl Urea, Methylparaben, Propylparaben.

Ingredients in Your Best Face Control

Reverse osmosis water, argireline (acetyl hexapeptide-3), cyclomethicone, ppg-5 ceteth-20, matrixyl 3000 (palmitoyl oligopeptide, palmitoyl tetrapeptide-3), c10-30 alkyl crylate crosspolymer, dimethyl isosorbide, ascorbyl tetraisopalmitate, spin trap (phenyl butyl nitrone), jojoba, nylon 12, idebenone, triethanolamine, alpha lipoic acid, polysorbate 20, sodium hyaluronate, vitamin e, paraben du.