close-up of cells

Epidermal growth factors are among the big breakthroughs in anti-aging skincare actives. They have been around for a good while though, having been first identified as wound healers more than 50 years ago. The stimulation of wound healing and of collagen production by EGF is due to increased fibroblast proliferation. Animal saliva has tons of EPG, giving new force to the concept of licking one’s wounds. Over the years, the Truth In Aging community has made some great discoveries of anti-aging products that feature epidermal growth factors and this is my current take on the Five Best.

  • AQ Skin Solutions Eye Serum

    AQ Skin Solutions Eye Serum ($99 in the shop). AQ’s eye serum remains an outstanding bestseller and I go back to it over and over. The growth factor is a sophisticated complex with TGF-Beta, GM-CSF and PDGF. These signal the cells to repair, stimulate collagen and produce glycosaminoglycans. They also inhibit matrix degradation. They also — at least in my case — make eyelashes grow. AQ has also ensured that this eye serum is a good all rounder with the collagen-boosting peptide complex Matrixyl 3000 and dipeptide 2, a depuffer that improves lymphatic drainage.
  • Stemulation Hi-Impact Serum

    Stemulation Hi-Impact Serum ($185 in the shop). The approach that stimulation has taken is to blend epidermal growth factors with vitamin C ester to optimally boost collagen production. This serum really is a great favorite of mine and can be trusted to give my skin a velvety glow. The key ingredient is sH-oligopeptide-1, which has an identical chemical structure to an epidermal growth factor. There’s a ton of brightening ingredients including Madonna lily leaf extract, which according to at least one study may prevent hyperpigmentation by inhibiting tyrosinase activity, sodium lactate, vitamin C and niacinamide. And there is hexapeptide-33, which is said to brighten skin as well as repair wrinkles.
  • ExPürtise Effective Anti-Aging Face Serum

    ExPürtise Effective Anti-Aging Face Serum ($120 in the shop). Expurtise doesn’t mess around. The first 12 ingredients in this serum include Matrixyl 3000, hyaluronic acid, Matrixyl Synthe 6, vitamin A, vitamin E, vitamin C, apple stem cells and epidermal growth factor (EGF). This new brand launched in 2015 with a mission to combine natural ingredients with proven heavy hitters, no fillers or nasties. With great results reported by testers in the Truth In Aging community, ExPürtise is a very welcome addition to this year’s Five Best.
  • E'shee Clinical Esthetic Elixir of Life KI Therapy Serum

    E'shee Clinical Esthetic Elixir of Life KI Therapy Serum ($189 in the shop). This is E’shee's most potent formula and combines growth factors (FGF 1) and Far Infrared Ceramic Powder (cFIR). E’shee says it “firm skin, increase volume, smooth texture, reduce redness caused by rosacea and repair broken capillaries” and it does all of that for me and I go back to it again and again. FGF’s are the building blocks of any fibrous tissue in the body and the far infrared boosts the fibroblasts that express transforming growth factor-(TGF-1). Yes, I know there are parabens and I wish there weren’t.
  • Skinfinite Peptide Repair Serum

    Skinfinite Peptide Repair Serum ($69 in the shop). This well-priced serum has rH‐Oligopeptide‐1 (EGF), a recombinant human growth factor. It is in the fibroblast cells of the skin and aids in stimulating cells so that they produce collagen. Skinfinite’s formula has some other heavy hitters as well, including alpha lipoic acid, CoQ10, spin trap and vitamin C, A great example of why Skinfinite is deservedly popular for its quality ingredients and decent price points.