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Glycolic acid and pH levels- getting the balance right

December 21, 2010 Reviewed by Marta 14 Comments
Glycolic acid is one of the cosmetic industry’s favorite weapons and so Dermagenics got my attention when its new cream proudly (perversely?) claimed to be glycolic free. I mentioned this in my post on Dermagenics the other day and afterwards received an email from the company’s CEO that made me realize that we might need to take care about what kinds of potions our glycolic comes in.

It seems that it all comes down to pH balance. As Debbye McGlothen, the CEO of Applied Skin Technology (the company behind Dermagenics) put it:

“Glycolic acid and AHA’s rely on a low pH of about 2 to be effective at drying and peeling the skin. On the other hand, moisturizing products operate in the normal skin pH range of about 5. Moisturizers claiming to have alpha hydroxys and/or glycolic acids in them will actually neutralize the acids, thus rendering the acids inactive. Thus, it becomes more of a marketing issue than a skin health issue. Additionally, there is some gray area as to the efficacy of over use of AHA and glycolics, even at this reduced effectiveness combination.”

A few days later I noticed that Dermaquest advertising that its Glycolic Acid 30% Resurfacer With Stem Cells with this tag: “lower pH increases product efficacy”. It struck me that I should look a bit further into the issue of glycolics and pH levels.

It seems that in addition to the level of glycolic acid, pH also plays a large part in determining the potency of glycolic acid in solution. Physician-strength peels can have a pH as low as 0.6 (strong enough to completely keratolyze the epidermis), while acidities for home peels can be as high as 2.5.

Some companies claim it is possible to raise the to raise the pH of glycolic acid closer to the pH of skin, without compromising its efficacy.  For example, VIVITÉ (owned by the Botox company Allergan) says its uses a proprietary buffering process called “partial neutralization”, a technology that is the “result of more than 10 years of scientific study”.  I’m not really sure how this works, but VIVITÉ claims that the glycolic acid is released over an extended time period.  The only thing I can add to this is that I have tried VIVITÉ and was not impressed by the results.

It seems that most neutralized products range from pH 4 to pH 7. The normal acid mantle of the skin is approximately pH 5.4. I’m not sure what happens to glycolic acid at the 5-6pH level. But I did read (source) that at a pH of 6.2, 85% of the glycolic acid is neutralized. At a pH 7.0, 100% of the glycolic acid is neutralized to salt.

Even the FDA has weighed in on the issue and says that products containing AHAs glycolic and lactic acid are safe for use by consumers if the AHA concentration is 10% or less and the final product has a pH of 3.5 or greater.

Just when I thought I’d got a handle on this, I confusingly found a 1996 study on the effects of glycolic acid at pH levels of 3.25, 3.80, and 4.40, and at 3.25%, 6.50%, 9.75%, and 13.00%. It concluded that: “All pH levels and concentrations demonstrated significant improvement in the condition of the skin with trends implying that increasing the pH increases efficacy.”

When I looked for more studies, I found that typically they looked at the every high (50-70%) concentrations used in chemical peels. One suggested that a pH level below 2 resulted in more “necrosis”, which means premature cell death.

Overall, it seems that pH level does matter. The lower it is, the more likely the glycolic acid product is going to sting and damage cells. The higher the pH level, the more likely the acid will be compromised (at least that seems to be the consensus).  So, where possible, look for products that give you information about the pH level as well as the acid concentration so that you can work out what the trade off is before buying something and wondering why it doesn’t work.
  • December 1, 2018

    by jignesh virani

    dear all
    i am very much agree with this write up, but as per my technical experience on glycolic acid peel it is depend upon the formulation , there lots of factors affected on final result avails finally, partial neutralization concept, on which buffer company has selected , after 100% neutralization which buffered acid is used for re ph, base materials types, penetration enhancing formulation,
    therefore, we have to aware about the formulation and ph and final pKa value, actually glycolic acid is too much enough to replace stratum corneum which is hurdle our beauty, also help in remove acne, removes pigmentation,after all expertise requires in skin selection.

  • May 19, 2015

    by Amanda

    I started using a 3% glycolic acid everyday a month ago...also with my face oil which has rentinal A in it...I now have brown spots on my forehead and side of my face.

  • March 6, 2015

    by dar

    What happened to MD Forte.? Was it any good?

  • September 7, 2014

    by Cass

    Folks Tsp of lemon juice+ tsp brown sugar. Stop paying money for the same chemicals they use in Elmer's glue.

  • July 7, 2014

    by JEC

    Hi there, hopefully there is someone that can help me figure out a PH concentration issue with regards to GA. One scholarly article points out that at PH2, GA is 100% effective, or in other words a 10% GA would behave at 10%. Moreover, it states that at PH4, it would be 35% effective, hence a 10% GA would in fact act as 3.5%, and at PH6 or higher, it is neutral, hence not active. From my own experience, it seems a neutral PH GA does indeed work.

    Does anyone know how to calculate this number?

  • March 7, 2013

    by Pink Moped

    I so wish someone could elaborate more on this statement

    "Moisturizers claiming to have alpha hydroxys and/or glycolic acids in them will actually neutralize the acids, thus rendering the acids inactive"

    What excatly in moisturizers neutralizes the acid.?? Oils?? Humectants??

    Is this implying that O/W and W/O emulsions cannot contain effective Glycolic acid??

  • April 26, 2012

    by Gabi

    Thanks for the post. I think pH level is really important for anyone using acids. The issue is that cell death (necrosis) is not the purpose of a medium or deep peel; it's collagen production, which is induced by the body's healing system--which gets a jump start when we injure it (via medium or deep chemical peels). Using chemical peel agents at high pH levels can achieve these results, but it takes much longer. The optimum solution is to kick start the process with a lower pH level medium peel then maintain it with a higher pH level product. I've done many chemical peels, and it's all about the desired outcome:

  • June 27, 2011

    by Jullie

    Hi Val
    i have been using retin-a for a about five years now prior to using the tca peel. retin-a will keep skin looking refreshed. however here in sydney australia has been out of stock for a year now and now use generic which is less drying. i only use the tca peel once a month.

  • March 10, 2011

    by Sunday

    Hello Val~ I also use Cellbone, my strongest serum in my arsenal is their Glycolic C Super Serum. I've never tried their peels or any peel for that matter (call me scared) anyway when I first found TIA at that point I also had decided to try the Lumixyl Brightening System. I've come to the conclusion that hydration/moisture, exfoliation, softening crow's feet etc... are more easily accomplished THEN DIMINISHING MY DARN HYPERPIGMENTATION SPLOTCHES ~ whew ~ I think I'll even manage to keep sagging at bay before the hyperpigmentation ever goes completely away!!! But I did have great results with the Lumixyl Brightening System, here is the link where I purchased;

    You may be able to find it cheaper elsewhere.

    So I bought the system, used it for 2 months with what for me was great result and then stopped due to that it is drying and it did what it said it would. 1/2 of my splotches now really look like freckles (I can live with that) and my more stubborn splotches (the ones I'll have to make peace with) are definitely diminished in size and appearance ~ in general I was happy, VERY happy!

    When I bought the full system I also received a complete travel set (each little tube is .33oz), never used, you can have it. I don't know if you want it ~ but if you do, it's yours. How we make this happen ??? perhaps we email Marta ~ I'll wait for your comment.

    Anyway I just thought this is a good option to a peel, at least it was for me ~ Take care.

  • March 10, 2011

    by Val

    Julie - about the Cellbone G/L TCA 45% serum, (i also have tried and like Cellbone 30% glycolic peel). I would like to try to "erase" deeper layers of hyperpigmentation, etc, but i do not want to apply what would be a deep peel, what with potential scarring, long recovery time, etc.

    I would like to ask you, please:

    How "adjusted" (to glycolics, retin A, etc) would you say that your skin was before trying the Cell bone G/L TCA 45% serum?

    Also, any chance of glycolics or peels in general resulting in the appearance of "thin" skin ?

    Many thanks for your reply - Good luck!

  • December 28, 2010

    by marta

    Hi Julie, I definitely wouldn't use it more than once a week.

  • December 28, 2010

    by Julie

    i have been using a a home peel from Cellbone G/L TCA 45% serum, which has 20% gylcolic, 15% lactic acid, 10% TCA. i use once a week. my face looks very refreshed after use.i requested the ph from the company and their response was 1.2. does this mean i am doing more long term damage than good??

  • December 22, 2010

    by marta

    Hi Betty, first of all you'll be looking for information on the concentration and pH level. For example, La Vie Celeste's glycolic mask is very gentle with a 5% concentration of glycolic and a pH of 4. This is about my speed. However, if you want something stronger, you'll be looking for a lower pH and a higher concentration.

  • December 22, 2010

    by Betty

    SO what should we look for in a home glycolic peel?

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