Kinerase, the antiaging skincare brand fronted by Courtney Cox, may have to give way to a successor called Pyratine-6. Kinerase is based on a plant-derived growth factor called Kinetin and the makers of Kinetin, a company called Senetek, has come up with a second-generation version of the growth factor that it is calling Pyratine-6. A bunch of Pyratine lotions and creams are already on the market, so are they any better (or worse) than Kinerase?

When I originally took a look at Kinerase and Kinetin, I originally thought that there were legitimate, independent studies to back up Kinetin's efficacy at fighting aging skin. Closer inspection revealed that they were conducted by members of Senetec's advisory board. I wondered if Pyratine-6's scientific pedigree would be more convincing. Perhaps. This time, Senetec got an independent lab in Texas to evaluate Pyratine-6 and then compare the results with original University of California Kinetin study.

The most striking thing about the comparison is how feeble Kinetin was (is): fine wrinkles (22% improvement with Pyratine-6™ vs. 2% improvement with Kinetin after eight weeks), skin roughness (86% improvement with Pyratine-6™ vs. 35% improvement with Kinetin after eight weeks) and overall skin aging (24% vs. 3% after eight weeks).

In Pyratine-6 Creme ($130), this key ingredient appears as Furfuryl Tetrahydropyranyladenine. I hope it is potent since it appears fourth from the end of the ingredients list and the most exciting thing that precedes it are soluble collagen and aloe vera.

Ingredients in Pyratine-6 Creme

Aqua (Water), Glyceryl Stearate, Laureth-23, Isopropyl Palmitate, Stearic Acid, Propylene Glycol, Cetyl Alcohol, Carthamus Tinctorius (Safflower) Seed Oil, Stearyl Alcohol, Glycine Soja (Soybean) Sterols, Dimethicone, Imidazolidinyl Urea, Aloe Barbadensis Leaf Extract, Triethanolamine, Methylparaben, Soluble Collagen, Carbomer, Propylparaben, Panthenol, Furfuryl Tetrahydropyranyladenine, Sodium Hydroxide, Ascorbic Acid, Hydrolyzed Elastin.