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Is Pyratine-6 Creme the successor to Kinerase

Is a Solution for:
Sagging Skin
November 15, 2009 Reviewed by Marta 6 Comments
Kinerase, the antiaging skincare brand fronted by Courtney Cox, may have to give way to a successor called Pyratine-6. Kinerase is based on a plant-derived growth factor called Kinetin and the makers of Kinetin, a company called Senetek, has come up with a second-generation version of the growth factor that it is calling Pyratine-6. A bunch of Pyratine lotions and creams are already on the market, so are they any better (or worse) than Kinerase?

When I originally took a look at Kinerase and Kinetin, I originally thought that there were legitimate, independent studies to back up Kinetin's efficacy at fighting aging skin. Closer inspection revealed that they were conducted by members of Senetec's advisory board. I wondered if Pyratine-6's scientific pedigree would be more convincing. Perhaps. This time, Senetec got an independent lab in Texas to evaluate Pyratine-6 and then compare the results with original University of California Kinetin study.

The most striking thing about the comparison is how feeble Kinetin was (is): fine wrinkles (22% improvement with Pyratine-6™ vs. 2% improvement with Kinetin after eight weeks), skin roughness (86% improvement with Pyratine-6™ vs. 35% improvement with Kinetin after eight weeks) and overall skin aging (24% vs. 3% after eight weeks).

In Pyratine-6 Creme ($130), this key ingredient appears as Furfuryl Tetrahydropyranyladenine. I hope it is potent since it appears fourth from the end of the ingredients list and the most exciting thing that precedes it are soluble collagen and aloe vera.

Ingredients in Pyratine-6 Creme

Aqua (Water), Glyceryl Stearate, Laureth-23, Isopropyl Palmitate, Stearic Acid, Propylene Glycol, Cetyl Alcohol, Carthamus Tinctorius (Safflower) Seed Oil, Stearyl Alcohol, Glycine Soja (Soybean) Sterols, Dimethicone, Imidazolidinyl Urea, Aloe Barbadensis Leaf Extract, Triethanolamine, Methylparaben, Soluble Collagen, Carbomer, Propylparaben, Panthenol, Furfuryl Tetrahydropyranyladenine, Sodium Hydroxide, Ascorbic Acid, Hydrolyzed Elastin.
  • December 17, 2017

    by Susan

    I had been a user of both the kinerase night cream and the day cream. I was very happy with the results, my skin is dry. I have not been able to find it for several years now. Is it still being made, what has replaced it and where can I find it. Thanks

  • October 19, 2017

    by Frank

    Hello Marta, please allow me to introduce myself, I am the CEO of Pyratine LLC, a scientist by training who has been highly involved in the development of several highly effective products such as Epipen(R) Trainer, Temovate(R) (clobetasol proprionate), Renova(R), Kinerase(R) (kinetin), etc. . . and of course Pyratine(R). We are conducting a new outreach program and would like to take this opportunity to invite you to be involved which would include receiving product information and samples for evaluation. I have read your review above on Pyratine-6(R) which speaks to "feeble results for kinetin" - as you know, there is only one anti-aging drug that is approved by the FDA and that is Renova(R) by JNJ - the results with Kinetin and Pyratine(R) are superior or equivalent for all measurement parameters in comparison to Renova(R)- all studies were done by investigators that actually wrote the FDA protocols for gaining FDA approval for the treatment of anti-aging. I can assure you that these were most independent investigators and prominent in the dermatology community. It is most noteworthy to point out with certainty that the majority of anti-aging products on the market are not clinically tested. . . having been on an expert panel with the likes of the head of the FDA claims regulator several years back, it was most interesting to learn of the situations they encounter, e.g., the majority of the AHA (alpha hydroxic acid) products were dead on arrival, i.e., when they hit the shelves due to the fact that they were formulated at an incorrect pH. We, at Pyratine LLC , operate under FDA guidelines and would never put out a formulation that was not thoroughly tested for both safety and efficacy, that did not provide differential advantages over existing treatments nor EVER combine ingredients in the same formulation unless said ingredients were tested so that there were no antagonistic reactions - this is not standard throughout the industry. Sorry for the long email, looking for your help and input. Thank you, Frank

  • March 16, 2016

    by denise

    FYI I bought some of this lotion based on the ingredients listed above and am also a former Kinerase c8 customer. This pyrite-6 is TOTALLY different. I have been using it for about 2-3 weeks and my skin looks terrible and completely different then before I used it. , larger pours, defined wrinkles and dry (I live in hawaii so it shouldn't look dry!) I then looked at the ingredients and it is not what you reported. My bottle says the following in this order
    Aqua, Glyceryl Sterate & PEG-100 sterate, Stearyl Alcohol, Propylene Glycol, Carthamus Tinctorius seed oil, Cetyl Alcohol, Ethyhexyl Hydroxystearate, Phenoxyethanol, Methylparaben, n-Butylparaben, Ethylparaben, n-propylparaben, iso-butylparaben, dimethicone, sodium benzoate, carbomer, glycine soja sterols,panthenol, triethanolamine, furfuryl tetrahydropyranyladenine, sodium hydroxide, disodium EDTA, Tocopheryl acetate, aloe barbadenisis leaf extract, Chamomilla recutitia flower extract, Royal Jelly extract, asocorbic acid
    So completely different including 4 more paragons then you list and unless you consider Royal Jelly ( 2nd to the last ingredient) a soluble collagen, there isn't any!

  • February 4, 2016

    by alison

    Hi- Please can you advise what would be a alternative to kinerase no6 c8 peptide intensive treatment as it is now discontinued- i am very disappointed but would appreciate your feedback as to any product that is as good if not better than kinerase intensive treatment.

    thanks you

  • November 24, 2009

    by Derm. P. Haabach

    Kinerase is NOT related to PyratineXR.
    Senetek PLC is the inventor and patentholder. They sold the rights to Kinetin which is used in Kinerase, to VALEANT PHARMA.

    PyratineXR is much powerful and better agains wrinkles that Kinerase

  • November 15, 2009

    by Tavo

    I just found out today about Kinerase's Under eye lotion. It's good to see that a company with solid products already in the market, is still striving to make better products.

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