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Is Reviva TGF Beta-1 Cream really a growth factor

Is a Solution for:
Sagging Skin
September 24, 2009 Reviewed by Marta 5 Comments
When Aerwin told me about Reviva's TGF Beta- 1 Cream ($35), I immediately thought that it was based on a transforming growth factor (TGF) and here was Reviva once more at the cutting edge of cosmetics with a keenly priced product. This turned out to be true, but it must be admitted that in this case Reviva has taken a bit of cosmetic licence.

On its website, Reviva says that "TGF Beta- 1 Cream features a brand new peptide... Palmitoyl Tripeptide 3 with functions different than other peptides and considered a high-tech 'tissue growth factor'. Partnered with Homestatine this combination influences cell metabolism, stimulating development and cell migration while determining their shape.

Palmitoyl tripeptide 3 (it used to be pt 5) isn't exactly a transforming growth factor. Otherwise known as Syn-coll, it is a small peptide with a unique sequence to mimic the human body’s own mechanism to produce collagen via TGF-β, tissue growth factor. All well and good, but by calling its cream TGF Beta- 1, Reviva's had me a bit confused.

In fact, TGF-beta (1-3) is a little different. This is a 'super' protein that controls cell functions such as growth and proliferation. It also regulates cell death. Studies at Cornell, Vanderbilt and Jefferson show that TGF-beta stimulates collagen and elastin. It is taken from human cells and used in products by Jan Marini, A&G and ReLuma.

This doesn't mean Syn-Coll isn't a good ingredient as well. The claims for Syn-Coll are eye-brow raising, to say the least. Collagen production is increased by 119% and the manufacturer says it will actually remove wrinkles. It is claimed that a 2.5% concentration of Syn-Coll outperforms the darling of the peptides, Matrixyl, at 10%.

Meanwhile Homeostatine is a bit of a stretch as well. Galactomannan is actually the gum of the tara fruit as in a common food additive used as a stabilizer in things like ice cream. That basically makes Homeostatine a marine botanical - specifically, enteromorpha compressa. Research suggests that this seaweed is good at suppressing allergic reactions and in tests on food preservation is a free radical scavenger.

Funnily enough, while I was trying to find out what salicoyl phytosphingosine is, I came across a near identical cream to Reviva's called Physician's Complex Tissue Growth Factor selling for $66. Presumably the difference in price is due to the CoQ10 in Physicians. Oh yes, according to the International Journal of Cosmetic Science, salicyloyl phytosphingosine is based on natural lipids and when topically applied to the face, reduces the depth of wrinkles and improves skin texture in photoaged skin.

Ingredients in Reviva

Demineralized Spring Water, Glycerin (veg.), Olive Oil, Palmitoyl Tripeptide-3, Coconut Endosperm, Homeostatine (Marine Pentasaccharide & Galactomannan from Tara Fruit), Salicoyl Phytosphingosine, Myristly Alcohol, COQ-10, Hydrolized Soy Protein, Squalane, Soybean Oil, Carbomer 940, Cetearyl Alcohol, Simethicone, Xanthan Gum, Potassium Sorbate, Sodium Benzoate, Citric Acid.

Ingredients in Physician's Complex

Demineralized Spring Water, Glycerin, Olive Oil, Palmitoyl Tripeptide-3, Coconut Endosperm, Homeostatine (Marine Pentasaccharide & Galactomannan from Tara Fruit), Salicoyl Phytosphingoside, Myristyl Alcohol, Coenzyme Q-10, Hydrolyzed Soy Protein, Squalane, Soybean Oil, Carbomer 940, Cetearyl Alcohol, Simethicone, Xanthan Gum, Potassium Sorbate, Sodium Benzoate, Citric Acid.
  • June 6, 2011

    by Sandra E

    I have been using this TGF-beta cream for over a year and it is great. My wrinkles seem to have smoothed out..I would not be without it!

    I also use other creams..and add DMAE to a regular day cream for a treatment. I had Rosacea at one time and I tried lots of stuff - this cream is one of the best...I use it AM & PM when I take my meds! Good way to remember to use it.

    This brand has some very good products and the price is right. Do your homework and compare the ingredients of the very expensive known brands that work, and you will find affordable very similar stuff you can afford. I do not think there is a need to purchase $500. face creams any longer..not when there is a brand like Reviva around.

  • January 30, 2010

    by tman

    I have used Reviva TGF-1 over several months. It seems to work best over a light moisterizer. I did notice some collagen growth. Its not as irritating as Retinol. One may want to do 2 weeks Retinol, then switch 2 weeks Reviva as a continued treatment.

  • September 24, 2009

    by marta

    Barbara you are right, I overlooked CoQ10. Either they are part of the same company/group or someone else makes batches of cream and sells them to companies to put their own brand on.

  • September 24, 2009

    by Barbara

    Hi Marta,

    But according to the ingredients list posted above, Reviva cream also contains Coenzyme Q10, so there is now difference! It is really strange?! The same company must stand behind these two brands..

  • September 24, 2009

    by aerwin

    I think I am going to give this a shot. I am more than pleased with Reviva's Dmae cream. I believe I can use this product under it. Reviva has not disappointed me yet.

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