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Isomers, NCN and Firm Skin 20% Matrixyl serums compared

Is a Solution for:
Sagging Skin
Reviewed by Marta March 8, 2011 22 Comments
An email from a reader last week prompted me to look at and compare 20% Matrixyl 3000 serums. A few months ago, I reviewed NCN’s 20% Matrixyl Serum and now I have found that there is a near identical one by Firm Skin. Things really started to get interesting when I spotted one from Isomers. Three very similar products, but some very different price points.

Matrixyl 3000 is a collagen building formula based on two peptides. Although there is no independent research on Matrixyl 3000, the anecdotal evidence is persuasive and it has become one of the “it” ingredients of the cosmetics industry.

Matrixyl 3000 is made by a company called Sederma and its own trials show very positive results (30% reduction in wrinkles) at a 4% concentration. I don’t know whether there are exponentially greater benefits to having so much more Matrixyl 3000 in a serum. On the contrary, it is conceivable, that the law of diminishing returns could kick in. Either way, the makers of 20% Matrixyl solutions are clearly banking on the fact that we’ll believe that more is more.

So what’s in these serums and how do they differ? Well, Sederma’s precise formulation (the INCI) for Matrixyl 3000 is Glycerin (and) Water (and) Butylene Glycol (and) Carbomer (and) Polysorbate 20 (and) Palmitoyl Oligopeptide (and) Palmitoyl Tetrapeptide-7.  NCN, Firm Skin and Isomer’s 20% Matrixyl 3000 serums all contain these ingredients.

What does differ is the base: linseed extract in the case of Isomers Matrixyl 20% Solution, water and aloe for NCN and water for Firm Skin. The preservatives are all slightly different too. NCN has added a couple of additional ingredients, cucumber extract and chrysin, an anti-inflammatory.  Although not identical product twins, they are as you can see from the ingredients listings below, very similar.

As for pricing, NCN’s 20% Matrixyl Serum comes in at the best value at $38. Firm Skin’s 20% Matrixyl 3000 is $44.95. But Isomers, a much bigger brand, with airtime on Shop NBC, is an audacious $187.87.

Ingredients in Firm Skin 20% Matrixyl 3000

Distilled water, Palmitoyl oligopeptide, Palmitoyl tetrapeptide-7, Carbomer, Sodium hyaluronate, Glycerin, Aloe Barbadensis, Butylene glycol, Polysorbate 20, Triethanolamine, Benzylalcohol, Dehydroacetic Acid.

Ingredients in NCN

De-Ionized Water, Aloe Leaf Gel, Vegetable Glycerine, Palmitoyl Tetrapeptide-7, Palmitoyl Oligopeptide, Cucumber Fruit Extract, Chrysin, Hydroxysuccinimide, Palmitoyl Pentapeptide-4, Butylene Glycol, Steareth-20, Polysorbate- 20, Carbomer, Opitphen (natural preservative).

Ingredients in Isomers Matrixyl 20% Solution

Linum Usitatissimum (Linseed) Seed Extract, Glycerin, Aqua/Water/Eau, Butylene Glycol, Carbomer, Polysorbate 20, Palmitoylpentapeptide-4, Palmitoyl Oligopeptide, Palmitoyl Tetrapeptide-7, Phenoxyethanol, Tropolone.
  • February 21, 2017

    by Ilene

    Isomers at now Evine as previously stated is an AWESOME DEPENDABLE SKINCARE LINE! You can get affordable deals when the owner/chemist comes on to do their presentation. They have an extremely wide range of products. Their serums and creams can be cocktailed together and used with other brands of skincare if you prefer. It is an anti-aging company that caters to mature skin yet offers products for acneic skin for teens and young adults. They also have a mens line. There is something for everyone. As stated in a previous comment, they are based in Canada and you can call to ask questions concerning which products will mostly benefit you. I am African American and it works perfectly for ALL ethnicities and skin types. Please give them a try. I would suggest their exfoliating serum or enzyme serum prior to all other serums and creams to ensure product can permeate into the skin properly and won't just lay on top of your skin. I will be honest the only product I don't care for is the sunscreen amongst all of their products. I prefer a SPF serum or a light or dry oil sunscreen and Isomers is a white cream like most sunscreens so it's honestly just a matter of preference. Sunscreen is imperative so please use one that best suits you. I now have my sister using the products. Her skin has cleared from hyperpigmentation, breakouts, and dark circles under her eyes in just a month. Manuela, the co-owner who does the presentations, doesn't like anything really oily so don't worry there is nothing too heavy or oily in her and her husband, who is the co-owner as well as a chemist in their skincare line. My sister is 35 and I am 37. They recommend you use it for 28 days to see a difference and believe me you will. If you enjoy products such as La Mer and La Prairie etc by all means continue to use it, but please give this a try to incorporate into your skincare routine. You will see that you won't need it plus La Mer is highly comedogenic with mineral oil and silicones. I will admit I like La Praire, but for that price tag I'd much rather prefer to spend my money on Isomers any day of the week! Oh and last thing....DRINK WATER!

  • March 9, 2015

    by karen

    The Isomers on ShopNBC then SHOPHQ for a short while AND now EVINE.COM online BUT EVINE LIVE on TV, Suresh that was a lot.....ANYWAY the seller is a chemist And wonderful to listen/watch. DURING a sellers visit special offers and kits are offered. Some end in 24 hours. I don't know about EVINE ( what a horrible name....says nothing about what they ARE) but so far extremely unimpressed. I THOUGHT it couldn't get any worse but it has. IF YOU ARE LUCKY, the vendors are wonderful and you can get a deal. Remember to always ask the amount of product and how long it will last. I don't want to fall in love with something I cannot afford after the " Deal of the a Day" ends. THEY DO AS MUCH AS 6 months splitting up your bill, which is great BUT if you sign up for Auto Delivey you get the full bill on the mini- payments which lure you in. WITH THIS SAID....I WILL CONTINUE TO BUY ISOMERS and other non-regular visiting brands. I THINK THESE CHANNELS PURCHASE "x" amount of product then the vendors come to help them sell it I SUSPECT THIS "EVINE" is not financially prepared to buy a lot, so if you see it WANT it, don't waste time . ...go online (no tax then) and get it. Wednesday specials at (Canada ) call and ask staff what you want to address. THEY HAVE A BOATLOAD of products. Quite confusing. Ratings on Evine and I think Isomers. I love their stuff!

  • August 12, 2011

    by Lisa

    Isomers 1 0z matrixyl 3000 is actually 49.00 on shop nbc. big miss print on the price quoted above.

  • July 25, 2011

    by Marta

    Its a good point and I'd forgotten it. Thanks for posting again.

  • July 25, 2011

    by jc

    ugh, wish i could erase my post, when i skimmed through the comments i failed to see i already had stated my point...sorry for an extra post.

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