Isomers is one of those brands – like Cellbone – that has a lot of fans (including amongst Truth In Aging readers), but for some reason I have never quite embraced.  The other day, Shop NBC emailed me about an Isomers promotion and it prompted me to go back and take a look. I gravitated towards the Stem Genesis for Body ($56.25) and in the end I pressed the buy button.

I bought Isomers Stem Genesis for Body after spending quite some time perusing the ingredients. Although this is yet another product to feature apple stem cells (surely the ingredient of 2011), what really won me over was the peptide power that Isomers has packed in. This is, I believe, the first time that I have seen a body lotion with Syn-Tacks, the peptide that is supposed to put Matrixyl 3000 in the shade.

Syn-tacks is a combination of two synthetic peptides. In the case of Syn-tacks, these peptides are palmitoyl dipeptide-5 diaminobutyloyl hydroxytheronine and palmitoyl dipeptide-6 diaminohydroxybutyrate. According to the manufacturer of Syn-tacks, these two peptides interact with the most relevant protein structures of the dermal-epidermal junction and stimulates a broad spectrum of things responsible for youthful skin – laminin V, collagen types IV, VII and XVII and integrin – all at once.

Isomers has also included tripeptide-10 citrulline, which mimics a molecule that regulates collagen fibers. As we get older, decorin (the molecule in question) activity declines. The new peptide, tripeptide-10 citrulline, behaves like decorin so that the collagen fibers are fooled into thinking they should still be productive.

But what really pushed me over the edge, was a peptide that targets lumican. I must admit that my lumicans are something of a current obsession. Lumicans are involved in both the synthesis of collagen fibrils and their organization into functional fibers, ensuring the integrity of the extra-cellular matrix. Acetyl tetrapeptide-9 is a relatively new peptide that specifically targets lumicans.

There are, it has to be said, a couple of very odd ingredients in Isomers. Cyperus Esculentus is a kind of sedge, the roots have a similar composition to olives in that they are high in fatty acids. Researchers have found it to be a good mosquito repellent – potentially useful but not typically the function of a cosmetic ingredient.

Another mystery is Aqualance. This is erythritol (a sugar) and homarine HCl is supposed to boost moisture. Hormarine is n-methyl picolinic acid, a compound found in the muscles of crustaceans and may have something to do with the chemical defense system of molluscs. Other than there is no relevant information on it and nothing on Aqualance except the manufacturer’s claims that it is moisturizing.

There’s the usual nasties in the preservative department, but I am nonetheless excited to give this a try. I’d love to hear from anyone who already has.


Aqua/Water,Cetearyl Olivate, Sorbitan Olivate,Caprylic/Capric Triglyceride, Butyrospermum Parkii (Shea Butter) Extract, Cetyl Palmitate, Sorbitan Palmitate, Aloe Barbadensis Leaf Extract, Malus Domestica Fruit Cell Culture, Xanthan Gum, Glycerin, Lecithin,Tripeptide-10 Citrulline, Cyperus Esculentus Tuber Extract, Erythritol, Homarine HCl, Acetyl Tetrapeptide-9, Ascorbyl Glucoside, Palmitoyl Dipeptide-5 Diaminobutyloyl Hydroxythreonine, Palmitoyl Dipeptide-6 Diaminohydroxybutyrate, Sodium Hyaluronate (LMW), Sodium Hyluronate (HMW), Magnesium Ascorbyl Phosphate, Phenoxyethanol, Tropolone, Carbomer, Triethanolamine.