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LiftLab and Cell Protection Protein

Is a Solution for:
Sagging Skin
April 6, 2011 Reviewed by Marta 15 Comments
I have just been sent samples from LiftLab, a relatively new brand. LiftLab comes with an origination myth about which surely only the deeply cynical would think there was anything fishy.

It goes like this. An entrepreneur, Elliot Entis, and a UC Berkeley scientist found in arctic sea life something they called Cell Protection Protein (CPP).  They began selling it is a raw ingredient to “a very large and prestigious cosmetics company”, only to find that it was not using CPP in a high enough concentration to be effective.  They were using trace amounts for marketing purposes!  Never heard of that before, now have we.... Anyway, Elliot decided to do things properly and launched LiftLab with four anti-aging skincare products a serum, gel, eye cream and daily moisturizer.

There is a section on the LiftLab website called “Cell Protection Protein Studies” where we are told that CPP has for decades been researched by the US Army, biotechnology researchers, clinicians as well as LIFTLAB. References are made to clinical trials, but there are no external links to independent (peer reviewed) studies. Do a search on Cell Protection Protein and the first thing that pops up is LiftLab.  In the ingredients lists for LiftLab products, CPP appears as fish plasma protein.

So I tried to find something that connected fish plasma protein to some of the claims made by LiftLab for CPP, such as how it increases the viability of keratinocytes. I wasn’t able to. I was beginning to feel a little suspicious and so I then tried to find out a little more about Elliot Entis.

According to his bio for a 2010 conference called FutureVision, “Mr Entis is the co-founder and CEO of A/F Protein, the company that gave rise to AquaBounty Technologies and LIFTLAB”. So perhaps A/F Protein would provide a clue to the hidden powers of fish plasma protein.  I discovered that A/F Protein produces antifreeze made from natural proteins – fish proteins in fact. It turns out that arctic fish, capable of swimming around freezing waters, synthesize anti-freeze, a discovery made by Drs Garth Fletcher and Choy Hew (who are also both involved in LiftLab).

I still wasn’t quite sure what anti-freeze simulating fish proteins would be doing in my face cream. Although there are theoretical merits to slathering on such a thing on a frigid New York winter’s day. Then I read that another doctor, Boris Rubinsky (another LiftLab-er), found that these antifreeze proteins protect cells from death. So now it was beginning to make some sense. And CPP seems to be well paired in LiftLab's formula with adenosine, one of the main energy sources for cellular functions.

Having got Cell Protection Protein out of the way, a look at Lift & Fix High Potency Solution ($95 in the shop), LiftLab’s face cream reveals that most of its ingredients are land lubbing botanicals (although there is another curious marine extract, alteromonas ferment. I think this is more often called pseudoalteromonas ferment and has water binding properties, according to researchers in Barcelona). Coincidentally, the list of botanicals, including eggplant and turmeric amongst others, is almost identical to those in a product called Purity Balance by Cosmedix.

Its good to see that high up on the ingredient list is methylsilanol hydroxyproline aspartate. This is an amino-acid known for its skin-conditioning properties. It is found in both collagen and elastin, the protein that controls the elasticity of connective tissue fibers

One ingredient that I don’t particularly like the thought of is Osilift. This is a film former made from oat kernal and it adheres to the surface of the skin to give it a tight feeling. Its sounds like the cosmetic equivalent of a ski mask.

The LiftLab Lift & Firm Eye Cream ($95 in the shop) has, in addition to CPP, and has a couple of interesting peptides. Tripeptide-1 (here it is part of a formula called 1 Kollaren) mimics the relationship of the growth factors involved in the healing process and synthesis of collagen. Acetyl tetrapeptide-11, which is supposed to boost the synthesis of syndecan-1. Syndecan-1 functions as a transmembrane protein that contributes to cell proliferation, cell migration and cell-matrix interactions.

Although there are few too many silicones and things like pentaerythrityl tetraehylhexanoate that impart a superficial sense of softness (especially in the eye cream), overall LiftLab looks worthy of a little fishing expedition.

LiftLab in the TIA Shop

Ingredients in Lift & Fix


Water, glycerin, aloe leaf juice, methylsilanol hydroxyproline aspartate, ethoxydiglycol, peg-7 glyceryl cocoate, glycereth 26, methyl gluceth 20, butylene glycol, arnica, algae extract, oat kernal extract, alteromonas ferment extract, fish plasma protein (Cell Protection Protein), dipotassium glycyrrhizate, adenosine, glycosphingolipids, hordeum vulgare extract, sodium hyaluronate, beta-gluca, melia azadirachta leaf extract, amino esters-1, coccinia indica fruit, solanum melongena (eggplant) fruit extract, aloe flower extract, henna extract, ocimum sanctum leaf extract, turmeric extract, pearl powder, chamomilla recutita flower oil, bis-PEG-18 methyl dimethyl silane, phenyl trimeticone, jojoba wax PEG-120 esters, PEG-32, glyceryl acrylate/acrylic acid copolymer, cyclomethicone, alcohol, PPG-26-buteth-26, PeG-40 hydrogenated castor oil, benzophenone-4, acrylates/C10-30 alkyl acrylate copolymer, carbomer, disodium edta, triethanolomine, phenoxyethanol, caprylyl glycol

Ingredients in Lift & Firm Eye Cream

Water, squalane, butylene glycol, shea butter, cyclomethicone, dimethicone, isononyl isononanoate, dipentaerythrityl hexahydroxystearate/hexastearate, pentaerythrityl tetraehylhexanoate, cetearyl alcohol, mango seed butter, cetyl alcohol, panthenol, niacinamide, sodium hyaluronate, glucose, fish plasma protein (Cell Protection Protein), guanidine HCL, tripepide-1, acetyl tetrapeptide 11, gucosyl hesperidin, fennel fruit extract, hops extract, Melissa officinalis leaf extact, achilea millefolium , glycosphingolipids, glycosaminoglycans, hordeum vulgare extract, acetyl tyrosine, proline, hydrolyzed vegetable protein, dipotassium glycyrrhizate, adenosine, adenosine triphosphate, urea, allantoin, gycleryl stearate, cetearyl glucoside, stearyl alcohol, tocopheryl acetate, PEG-100 stearate, alcohol, mannitol, melia azadirachta flower extract, amino esters-1, coccinia indica fruit, solanum melongena (eggplant0 fruit extract, aloe flower extract, henna extract, ocimum sanctum leaf extract, turmeric extract, pearl powder, polyacrylamide, C13-14 isoparafin, laureth 7, corn starch modified, xanthan gum, disodium EDTA, phenoxyethanol, capryl yl glycol
  • June 23, 2011

    by adeanwiggins

    I have tried many thins for droopy eyelids nothing worked, I am interested in trying your product.

  • April 12, 2011

    by Lynn Mandeville

    At 52, I'm frantic about the puffy dark circles under my eyes and the droopy eyelids. I've always taken good care of my skin and it's just not fair! If I have droopy eyelids at 52, what are they going to look like at 65! Please let me try this product out. I get so excited when the next thing comes along, only to be disappointed that the promises don't pan out as I had hoped.

  • April 8, 2011

    by Jina

    Hi Marta

    Would also like to try this product am 49 and beginning to get cross thatching under the corners of my eyes. I hope if I catch this early It won't get worse. I do have sensitive eyes and react to most thing.

  • April 8, 2011

    by debbie rawls

    would love to give this a try, I am 51 yrs young :) and need help in the eye area

  • April 7, 2011

    by Denise

    I would love to try this product. I have not had much success with any eye products and am always looking for a "cure" for wrinkles and sagging around my 50 year old eyes!

  • April 7, 2011

    by Lauri Boni

    This product sounds hopeful for all of us with aging eyelids--I would love to be able to confirm real results (or not).

  • April 7, 2011

    by Janice

    I really wish that reviews of products were broken down into some sort of age groups. I am a bsn, rn and highly skeptical of most "anti-aging" products anyway but more so when I find out someone 40 or 50 is using them with great "success". I am over 60 and things have changed on my face not only by decade but also just in the last 5 years. I would love to try something genuinely new and feel I could provide an excellent objective review at least for someone in my age range. I would also review on my YT channel.
    Warmest Regards,

  • April 6, 2011

    by cristina gilmore

    If Liftlab really works on those droopy eyelids (like mine ;-( ) do you know how much anxiety that would quell? First the fact that there IS something that beyond a doubt works saving you time and money searching for the ONE. Second, at this point many of us think about 'eyelid surgery'...and that is not so simple. You must search for a doctor you trust and be able to afford it. I would love to be a guinea pig in this trial because that is where I am at. It's frustrating looking younger than your age but then when the sunglasses come off and they see your eyes ..well...then the truth is revealed. It's just not fair. It just seems that the downslide is faster than the road up.

  • April 6, 2011

    by Penny Grace

    LiftLab sounds so fascinating and if it does all that it's supposed to do, I will be a faithful consumer and avid supporter of it. My eyes, at age 60, look pretty good but are now showing some age - with few lines but really showing some droop and looking just plain tired. If I could just get tighter "refreshed" look again, it would be wonderful. I would be so grateful if I could use and review this new product for TIA. Thanks, Penny

  • April 6, 2011

    by Susan Brody

    I dare say that Liftlab could prosper nicely from turning back the clock on my eyes. Drooping lids, crows' feet, dark circles that when concealed look like highlighted crepe paper -- I've got it all. If that Lift & Firm stuff could make my 51 year old eyes look 25, that would be cool, as my eyes have looked like this since I was a teenager! 'Can't ask for more of a challenge that that, can you! (And you're sure to get a thorough report out of me because I'll probably spend a lot of time staring at myself in the mirror.)

    Marta, your site is divine -- straight answers on a plethora of tempting products; I'd love to join your team, even for just this one trial. Thank you for considering me. Susan.

  • April 6, 2011

    by Dolores

    I would love to test this stuff on my neck and eye's . If it worked on me(65 and sagging) it would work on anyone.

  • April 6, 2011

    by Nancy Davenport

    I'm still looking for that magic potion for 66 year old eyes..... maybe this is Cinderella's slipper for the eyes !!!!!!!

  • April 6, 2011

    by LIna Jacobson

    Oh yes please, a little humble begging is good for the soul! I've tried so many eye creams it's embarrassing besides expensive. Tough area to treat and to see results, so undeterred I'll submit my request for yet another try!

  • April 6, 2011

    by JustD

    I just bought the SenZen Double Dose eye cream, based on Sunday's review, great review btw, and I think it would be a great advent to do a side-by-side comparison of the two. What works for one may not garner the same results for another, that's why I have to be more careful in my selections; I've made a costly few boo-boos and I'm hesitant to jump in on just anything right now. I really needed an eye and face moisturizer, so Sunday's review came just in time for me and I bit the bullet and splurged at TIA on DD. I'd love to do a review on an eye or facial moisturizer or plumper while I'm saving up for my next batch of TIA purchases. LOL

  • April 6, 2011

    by Naheed

    Oh please Marta, you have to let me try this, I have big problem with my eyes, under eye bags, wrinkles, crow's feet. Please for once I would really want to try some thing new. Thank you in advance.

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