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Matrixyl significantly boosts collagen, says independent research

June 11, 2013 Reviewed by Marta 12 Comments

In a veritable breakthrough for Matrixyl watchers like me, there emerged in the last couple of days independent research proclaiming that the power peptide Matrixyl actually works to boost collagen. Researchers at Reading University in the UK say that “products with Matrixyl will have skincare benefits.”

Matrixyl is a peptide, palmitoyl-pentapeptide-4 (palmitoyl pentapeptide-3 before 2006), that is supposed to stimulate collagen and skin repair. Its big sister is Matrixyl 3000, a combination of two peptides: a palmitoyl tripeptide and a palmitoyl tetrapeptide. They are supposed work synergistically to mimic the appearance of this broken down collagen, causing your skin to react by producing more collagen, as well as elastin. But until now, we had to rely on the manufacturer of Matrixyl, Sederma, and Olay manufacturer, Procter & Gamble, for the research.

University of Reading researchers found Matrixyl can nearly double the amount of the protein collagen needed to give skin its elasticity. The team is led by Professor Hamley, who is something of a peptide-file and has been looking at ways to stimulate collagen for wound healing.

This is great news. Many of us – well, I can certainly speak for myself – have seen good results with Matrixyl 3000 based serums, but until now it has been subjective and anecdotal. That is one reason why I haven’t singled out the Five Best serums with Matrixyl for a few years. In celebration of this new research, I’ve updated it to a 2013 Five Best with Matrixyl including some new and powerful anti-aging products. 

I don’t know what concentration of Matrixyl the Reading researchers used. But Sederma’s research and recommended concentration is at 4%.

The Reading University research was paid for by “University studentship with some additional funding by the Engineering and Physical Sciences Research Council (EPSRC).”

See also our Five Best with Peptides

  • January 11, 2015

    by Effie

    On this subject, I am no expert but from what I can assess from this pharmaceutical site which does have the entire study, I think it shows the best results in a concentration of 8% which I think it's pretty high.

    I am no expert. Just a curious human. If you would like to check it out since you also have access to several chemists here is the link.

    http://pubs.acs.org/doi/abs/10.1021/mp300549d

  • June 22, 2013

    by Marta

    Hi Pat, the manufactuer, Sederma, claims Matrixyl 3000 is stronger. But there is no independent research on it.

  • June 22, 2013

    by pat

    so.............which is better? Matrixyl or Matrixyl 3000?

  • June 21, 2013

    by Marta

    Hi Susan, Matrixyl was tested

  • June 21, 2013

    by Susan

    Would someone clear up my confusion, please? Which one was tested: Matrixyl or Matrixyl 3000? (My understanding is the two are diverse.)

    Simple English is fine for me. :)

  • June 13, 2013

    by Marta

    So, I double checked the manufacturer's website and have amended the post accordingly to say the following: Matrixyl is a peptide, palmitoyl-pentapeptide-4 (palmitoyl pentapeptide-3 before 2006), that is supposed to stimulate collagen and skin repair. Its big sister is Matrixyl 3000, a combination of two peptides: a palmitoyl tripeptide and a palmitoyl tetrapeptide. This taken directly from Sederma.

  • June 13, 2013

    by Marta

    The study was in vitro. Matrixyl is palmitoyl pentapeptide-4 (palmitoyl pentapeptide-3 before 2006). Matrixyl 3000 based on two peptides: a palmitoyl tripeptide and a palmitoyl tetrapeptide - as per Sederma's website.

  • June 12, 2013

    by Debbie

    That is what I said Martha! LOL The article above, however, states that Matrixyl 3000 is palmitoyl oligopeptide and palmitoyl tripeptide. You post agrees with mine that it is in fact palmitoyl oligopeptide (Pal-GHK) and palmitoyl tetrapeptide (Pal-GQPR). Just FYI: I have always found it odd that the INCI name for the Pal-GHK in Matrixyl 3000 is palmitoyl oligopeptide since oligopeptide is nonspecific for the number of amino acids. Technically every palmitoyl peptide with 3 or more peptides is a palmitoyl oligopeptide.

  • June 12, 2013

    by Annie

    Thanks for your helpful reply

  • June 12, 2013

    by Debbie

    Other than Sederma's claims that Matrixyl 3000 is better than Matrixyl, we don't really have proof of anything since the two products have nothing in common. It is not just a matter of "an additional peptide". The two peptides in Matrixyl 3000 are totally different tha the peptide in original Matrixyl. (BTW: The name of the first peptide listed in Matrixyl 3000 should be Palmityol Tetrapeptide-7, not Tripeptide-3.) As far as concentration, the researchers stated that it required 80 PPM of the peptide to create 1.7 times (i.e. almost double) the collagen. Since it is almost impossible to buy Matrixyl anymore, I cannot (with a quick search) find technical information on how many peptide PPM are in Matrixyl as supplied. When 4% is listed by Sederma, that is the diluted registered TM product, not the actual peptide itself. I don't want to pay for full access to the PDF file for this study (I can only locate the abstract free of charge), so I also don't know if this the results were obtained on human skin or if it was an in vitro study. Do you have full access Martha?

  • June 12, 2013

    by Marta

    Hi Annie

    The researchers tested Matrixyl. However, to some extent it should be applicable to M3000 since it has an additional peptide and the manufacturer, Sederma, has always claimed that M3000 is even better than Matrixyl.

  • June 12, 2013

    by Annie

    Sorry I am a bit confused. Is the research applicable to both matrixyl and matrixyl 3000, or just matrixyl? Reading the research it sounds like it was studying matrixyl. Many thanks

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