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Medik8 Firewall Claims To Be an Antioxidant Winner

Medik8 Firewall 1 oz

Our Rating: 0 stars


Combination of copper and peptides is 40 times stronger than vitamin C


Inclusion of silicone and perservatives
May 2, 2009 Reviewed by Marta 4 Comments
A unique and promising product

A couple of days ago, a British dermatologist at the University of Manchester, published the results of a year-long study on a potion made by Boots (the Brit equivalent of Walgreens) saying it works. The scientist in question had already become a household name a couple of years ago when the BBC made a documentary about the science of skincare in which he said that Boots No 7 outperformed some more expensive brands and was as good as a prescription retinoid. Sales of Boots Protect & Perfect went through the roof and they doubtless will again with the publication of this week's study. Hitching a canny ride on this bandwagon is a new anti-aging serum called Medik8 Firewall ($145 in the shop).

Firewall has been tested, apparently, by the same University of Manchester team. The team tested Firewall, according to Medik8, against nine other "premium" (but unnamed) cosmetic brands and it soared way above them in terms of antioxidant activity against four major free-radicals.

I have a bottle of Firewall on my desk as I write this and a batch of marketing materials. It certainly looks very intriguing. For starters, the bottle is a double cylindered affair that has been designed to "ensure the formulation is only activated on produce the correct dose".

Medik8 makes a big deal out of a patent pending anti-aging complex called Cusodase-P, claiming that this is a blend of actives (they won't disclose which ones whilst waiting for the patent, but it seems likely to be a combination of copper and peptides) that is 40 times stronger than vitamin C. What I can deduce from the list of ingredients is that there is an array of antioxidants from well-known peptides to the somewhat rarer superoxide dismutase and ergothioneine.

The latter is found in mushrooms amongst other foods and has been given a big thumbs up by Dr Daniel Yarosh and is in his Remergent skincare line. It also recently showed by in Revlon's Age Defying Spa Foundation. However, the research as to how effective it is as an antioxidant is contradictory. Superoxide dismutase is certainly an antioxidant, but I haven't yet found much about topical applications of it except in a Japanese study, showing that it was effective at healing lesions and that it is stable.

There are several forms of copper in Firewall. Copper is the key mineral in lysyl oxidase, an enzyme which weaves together collagen and elastin, and there is a mountain of research on how topical applications of copper heal wounds. However, I am a little skeptical about colloidal copper, which seems to have snake oil abilities to cure everything from arthritis to graying hair.

An especially interesting ingredient is N-acetyl cysteine. This is produced in the human body and plays a role in the sulfation cycle, acting as a sulfur donor in phase II detoxification. Cysteine also helps synthesize glutathione, one of the body's most important natural antioxidants and detoxifiers. Also on the of-high-interest list is liprochroman-6, listed here as dimethylmethoxy chromanol. I wager that this is going to be an antioxidant to watch and that it will start showing up more and more in high-end, anti-aging potions. Lipochroman-6 is an able scavenger of two free radicals: RNS and ROS. According to Lipotec, who makes lipochronan-6, it does a significantly better job of fending off oxidative stress than resveratrol, the antioxidant component of grapes.

There is a little too much silicone in Firewall for my taste and I am dubious about the inclusion of the preservative sodium benzoate, which in a British study on yeast cells appeared to attack cells’ mitochondria, damaging their ability to prevent oxygen leaks that create free radicals. Methylisothiazolinone is another controversial preservative that is a skin irritant, as is methylchloroisothiazoline. These few misgivings aside, I'll be taking Firewall out for a test drive and will report back in a few weeks.

  • March 28, 2018

    by Will

    (5 out of 5)

    Been using Firewall for 2 years since turning 60 and it's been incredible in rolling back the years. My skin is tight and glowing and clear. I can pass for 45 now.

  • November 30, 2013

    by Marta

    (5 out of 5)

    I should leave a comment as an update on this review. I reintroduced myself to Medik8 this year and it was every bit as good - nay, better - than I remembered. Not only is this an innovative and unusual product, it really is very effective. I find that it firms skin and smooths wrinkles so well that I will include it in my 2013 Five Best anti-aging serums.

  • May 4, 2009

    by Emma Gregory

    Sorry that is (not and click Firewall button

  • May 4, 2009

    by Emma Gregory

    Declaration of interest: I am the chief cosmetic chemist at Medik8

    Dear Marta & TIA Readers,

    I am all in favour of totally independant review websites (I buy cosmetics too!) and appreciate the sceptisism of some parts of the otherwise positive article. While I could go into incredible detail as to the genuine level of hard core research that went in and continues to go in to the Firewall project I think you would benefit for the purposes of analysis by ingedient from knowing that there is a rule that ingredients put in a product at less than 1% can be listed in any order as long as they appear beneath ingredients higher than 1%. The majority of powerful actives (when purified and not as complexes) need only be included at around 1-5%. Therefore a whole raft of ingredients of perhaps neglegible trace concentration have been included in the product solely to throw off would be copy cats prior to patents being granted. Of the now three patents filed and them all around the world the first is to be published in a few months from now. In this first patent you will see the 9 other brands the product was tested against. We sincerely do not go out to speak negatively about other brands but we had to provide benchmarking data for the patent offices in the US and Europe therefore these tests and publishing the results were required. We will not and have not announced competitor names as you can see from marketing materials but once published there is nothing to stop you from Reading public patents.

    So in short this comment is two-fold 1) don't worry about the large list of ingredients. Most are trace and there for commercial reasons. 2) the results of the studies are soon to be public record and you will see how Firewall is a minimum of 5 times stronger than the next best alternative.

    Lastly to you Marta, good detective skills. You are warm in many of your guessed but missed a key active. But that was the whole point of our strategy and designed to fool P&G, L'Oreal scientists so don't be too disheartened.

    Firewall in it's current form is very popular but new research means an upgrade in 2010 for which further patents have been applied will mean an upgraded formula. Users now can switch and upgrade when the time comes.

    To get access to more information on the Firewall trial data now, try the legacy website and click on the Firewall banner/button.

    Great site Marta and team. Looking forward to the full review

    Emma Gregory
    Medik8 Chemist

    Ps. The silicone level is a design feature as film forming and allows better application of sunscreens and makeup on top.

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