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Osmosis Replenish Review

Osmosis Replenish 1 oz
November 23, 2009 Reviewed by Marta 12 Comments
TRU Rating
Smooths and resurfaces the face


An excellent combination of actives with no nasties



The serum gods are smiling on me these days. There have been so many recent scores - such as the impressive Skin Nutrition Cell CPR - that I shall probably have to update our Five Best Anti-Aging Serums in the non too distant future. One of the latest to achieve recommended status is Osmosis Replenish ($52), which I'd say is powerful enough to make its mark on full-blown wrinkles as well as fine lines. This is one is a skin smoother.

Osmosis Replenish has already caused a bit of controversy with readers questioning the use of niacinamide alongside resveratrol and the inclusion of ethyl alcohol. I investigated the niacinamide issue and concluded in a post that it is a worthy ingredient in every sense. Topical application of niacinamide has been shown to increase ceramide and free fatty acid levels in skin, prevent skin from losing water content, decrease hyperpigmentation and stimulate microcirculation in the dermis, according to many peer published studies. Regarding the alcohol, I do notice a fleeting (and I mean a second or two) tingle when I first apply Replenish, but otherwise have noticed no irritation (and I have very sensitive skin).

Having got that out of the way, it should be noticed that the rest of Osmosis Replenish ingredients pack a powerful antioxide punch with nothing at all from the Truth In Aging nasties list. I have written about the dominant ingredient, phosphatidycholine, before, so I'll focus here on a couple of others. Always worth a shout out is one of my favorites, spin trap. A signature ingredient of the Your Best Face range, it is a very effective radical scavenger. So too is catalase. This enzyme is super useful in that it is the catalyst that turns hydrogen peroxide into water and oxygen, which is naturally occurring but builds up over time. One of the real superheros in Replenish could well be chlorella vulgaris extract. A bright green algae (pictured), it is loaded with amino acids such as lysine, proline, glycine, and alanine, all of which are the essential building blocks of proteins and constitute each individual collagen unit. Its large amino acid component leads many to believe that it has the ability to restructure and smooth out the surface of the skin, particularly with scarred or aging skin. Furthermore, itis an excellent source of methyl-cobolamine, the most absorbable form of vitamin B12. In some studies, a small concentration of .016%  stimulated collagen synthesis and concentrations of .4% strongly increased the density of the epidermal layer. Meanwhile, ferulic acid is something of an unsung hero of the antiaging cosmetic world. A 2004 Italian study concluded that ferulic acid is a more powerful antioxidant than alpha-tocopherol (vitamin E), beta-carotene, and ascorbic acid (vitamic C).

Osmosis also sent me a separate pot of L-ascorbic acid so that I can choose how much to add. What an intelligent idea. For my test, I tried Replenish without the vitamin C and I was still impressed with the results. Over the next few weeks, I'll try adding it in and see what happens. The only downside to this excellent antiager is that it isn't easy to get as it seems to be distributed through dermatologists and salons.

  • January 31, 2011

    by JustD

    I played with that thought for about a minute, Danny, but figured, as you, that unless they get a barrage of complaints, it may fall on deaf ears. So, that said, if anyone else is experiencing a similar frustration with OR, whaddaya think? Shall we send Dr. Johnston a few collaborated complaints regarding his container? :)

  • January 31, 2011

    by Dannyengland

    So true , I wrote and told dr Johnston that I lose loads of product as it ends up dripping from the light fittings. Something needs to be done asap. Maybe if everyone wrote to the main web site and told them

  • January 30, 2011

    by JustD

    I don't know about the reformulation question Dennis, I just began using this product this weekend, and I am such a novice, so disregard this comment. It's more like a rant as it's too early to see any real results, however, the container's pump gives me such grief! Everytime I attempt to depress the pump down, no matter how gently, it shoots out everywhere and I am losing product, which is highly frustrating. I've taken to shooting it into a little plastic container so that I can capture it all. Other than that, it goes on lovely and it feels just fine. I hope to see some results within the next week or two so that I can have something value-added to place here.

  • January 23, 2011

    by Dennis

    Has this been reformulated? at the TIA store astaxanthin is not listed. Anyone?

  • November 7, 2010

    by mennonite


    I'm happy to see a serum you highly recommend that contains less than half a page of ingredients - all of which I'm able to pronounce. And it's affordable to boot. I hope you're able to stock it in the TIA Store, but in the mean time I'll try to track it down elsewhere.

  • December 30, 2009

    by marta

    Rileygirl, this is a very belated reply to your question about CP and vitamin c (you posted when I was out of the country and I must have missed it). The only definitive statement about copper breaking down vitamin C is on the Skin Biology site. Some other sites say they shouldn't be mixed, but without saying why not.

    There are many different types of vitamin C that are more or less stable than one another. That may be factor. But I simply can't find any substantive info about this. Until I do, I'm not going to worry about it.

    Any chemists out there? Please enlighten us.

  • November 25, 2009

    by Mark

    Thanks so much for finding this and other affordable serums! The findings on the chlorella vulgaris extract are especially interesting.

  • November 24, 2009

    by Angela

    Thanks for the link, Kimberly Anne.

  • November 24, 2009

    by Kimberly Anne

    You can currently buy it here - you have to register as a customer on their site and they sell it for $40 + $7.95 shipping.

  • November 24, 2009

    by L

    It is a wonderful product!

  • November 23, 2009

    by rileygirl

    Marta, is it ok to add l-ascorbic acid to this product, as it contained GHK? I thought copper needed to be used 12 hours apart from C?

  • November 23, 2009

    by Angela


    I'm happy to see a serum you highly recommend that contains less than half a page of ingredients - all of which I'm able to pronounce. And it's affordable to boot. I hope you're able to stock it in the TIA Store, but in the mean time I'll try to track it down elsewhere.

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