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Osmosis Replenish tops up an antioxidant hit list

Is a Solution for:
Sagging Skin
October 29, 2009 Reviewed by Marta 10 Comments
I have just started to test an antioxidant serum called Replenish ($38 for 30ml) by Osmosis Pur Medical. I must admit, I am very excited: the ingredients list is a veritable who's who of the antiaging, antioxidant hit list. If the ingredients are all they are cracked up to be, this is going to be one powerful potion.

First up, there is phosphatidycholine. The only other time I have come across this is in Dior Capture R60/80. Some dermatologists are experimenting with it as an alternative to liposuction since it is believed that phosphatidycholine can target and dissolve fat cells. I mentioned it in a post on mesotherapy.

It isn’t going to be easy to try to explain what phosphatidycholine is without resorting to some long words. Anyway, I shall try to keep this as simple as I can. Phosphatidycholine is the predominant phospholipid (something that is in all life forms) of all cell membranes and of the circulating blood lipoproteins. It is made up of glycerol and fatty acids. Phosphatidycholine contains choline (and this is the interesting part), therefore, it is a precursor to messenger molecules that go from cell to cell. And it can improve and protect cells and membrane damaged by free radicals.

Osmosis has ensured that it is keeping good company with vitamin B3 (niacinamide), which increases ceramide in skin and has been shown to cure acne. It is also toxic, but only at doses far higher than used in cosmetics. Then there is catalase, an enzyme that occurs naturally in our bodies (but declines as we get older) and prevents too much hydrogen peroxide from building up.

Of course, I can't resist giving a shout out to spin trap, a busy molecule that hunts down free radicals and stops them from spinning out of control. It is the signature ingredient of Your Best Face. Other old friends include GHK copper peptide. In case you were wondering, the mouthful that is tetrahydrocurcuminoids is turmeric treated somehow so that is colorless rather than bright yellow.

Ferulic acid is something of an unsung hero of the antiaging cosmetic world. A 2004 Italian study concluded that ferulic acid is a more powerful antioxidant than alpha-tocopherol (vitamin E), beta-carotene, and ascorbic acid (vitamic C). Meanwhile, Duke University researchers blended it with vitamin C and E and proclaimed it a "potent ubiquitous plant antioxidant".

The full list of remarkable ingredients is below and, best of all, there is nothing not to like. I'll report back after a few weeks of testing.

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Purified water, phosphatidycholine, ethyl, niacinamide, glycerin, catalase, superoxide dismutase, L-glutathione, ferulic acid, CoQ10, tetrahydrocurcuminoids, spin trap, R-lipoic acid, astaxanthin, chlorella, trans resveratrol, GHK copper peptide, grape seed extract, curcumin, green tea extract, ginkgo biloba, essential oil blend
  • November 24, 2009

    by Kimberly Anne

    You can buy it here!!! :)

  • November 8, 2009

    by marta

    Jana, I have done some more research on niacinamide and I don't think there is cause for concern. You can read my post on niacinamide and sirtuins here

  • November 2, 2009

    by RV

    The "ethyl" you are referring to is indeed ethyl alcohol. Osmosis did try to formulate this product without alcohol - but with no success. According to Osmosis, the amount used is not signficant enough to result in any harm to the skin. The benefit is that certain active ingredients are able to dissolve in solution.

  • November 1, 2009

    by marta

    Thank you for sending me back to the ingredients list on the bottle. There is a comma between ethyl and niacinamide (which I have now inserted into this post). Although this raises another question, what is ethyl? I suspect it might be ethyl alcohol. Trans-reservatrol is actually a common designation for plain old resveratrol. As to your point about niancinamide negating NAD, this is not at all clear cut. There is a lot of conflicting information, including references that niacinamide is a precurser of NAD. There are other controversies about <a href="" rel="nofollow">niacinamide</a> being carcinogenic, although the studies are 20 years old. I'll spend some time trying to get to the bottom of this.

  • October 31, 2009

    by Jana

    I notice that Replenish contains both niacinamide (as ethyl niacinamide) and something called "trans-resveratrol." I've never seen the designations "ethyl niacinmide" or "trans-resveratrol," though it is my understanding that just plain resveratrol is a pro-sirtuin. And, it's my understanding that niacinamide most likely negates (i.e., suppresses) the action of sirtuins by contributing to NAD. Any thoughts, please, as I'm a bit flummoxed as to why Osmosis would use these two ingredients in one product. Thank you.

  • October 30, 2009

    by RV

    I have been using the Replenish daily for about 3 months. It makes my skin look and feel wonderful. One of the best antioxidant products I have found. I am also a huge fan of the Osmosis Shelter SPF 29+. It is one of my favorite daily facial SPF moisturizers (along with Pratima Neem Rose SPF 30, SanRe Organic Skinfood Supple Sunshine SPF 30 and Sweetsation Therapy Sun Brella Organic Triple Action Moisturizer SPF 30+).

  • October 30, 2009

    by marta

    Even worse...Osmosis seems to be ONLY available through spas and dermatologists. Assuming that my trial goes well, we'll try to get it for our store.

  • October 30, 2009

    by Asya


    Osmosis seems almost impossible to find. Where do you buy it (I'm suspecting your estetician again :-)?

  • October 29, 2009

    by rileygirl

    I love the Osmosis Boost, so I am very interested how the Replenish works! Looking forward to your review in a few weeks!

  • October 29, 2009

    by Kira

    Hi Marta, soo glad to see you mentioning this company. I am now trying out their signature product Boost, which is hopefully going to be as effective as Retin-A... As you probably know, the company uses a very interesting new form of vit A - Retinadehyde, which is supposed to be more effective than retinol and less irritating than Retin-A. Pls pls report back with your comments about Refresh, this is next on my list to try!

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