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Osmotics Lipofill plumps marionette lines- tested and recommended

Osmotics Lipofill
Is a Solution for:
Sagging Skin
November 29, 2009 Reviewed by Marta 12 Comments

I have been trying Osmotics Lipofill Non-Surgical Filler ($73) for the past three weeks. It is designed to target the labial nasal lines and I have confess I was more than a little skeptical at the start of my trial. Puppet lines or marionette lines stubbornly signal aging like nothing else. I haven't yet found a cream that really, really tackles them and my best weapon so far, since I don't want to resort to fillers if I can help it, has been LED treatments (I use a Baby Quasar at home). However, after adding Lipofill into my regime, I have seen an improvement: my skin was definitely plumper and a small groove at the corner of my mouth is diminishing.

I would guess that two ingredients are responsible for this relatively rapidly achieved plumping effect. As well as sodium hyaluronate, there is saccharide isomerate, which works as a moisture regulator by binding to the free amino groups of lysine in the keratin of the outer layer of the epidermis. I am curious as to whether the effects are only temporary, so I have stopped using Lipofill for a week to see what happens. Mind you, short-term results are better than no results.

In any case, Osmotics has added in some antiagers with staying power. At the forefront of Lipofill is rye seed. Rich in arabinoxylans that are responsible for the cohesion and mechanical resistance of the plant, Rye extract is said to act as an internal tensor and boosts the skin’s abilities to firm and lift. I have to admit that I haven’t found any research to back this up.

I was interested to discover that artemisia abrotanum, known as wormwood, contains four flavenols with spasmolytic activities. Spasmolytic is a type of muscle relaxer and so could be playing a role here as a kind of natural Botox. There is the tried and trusted peptide, Matrixyl and and tripeptide 1.

I am definitely going to go back to Lipofill after my week off. Using it daily in conjunction with a weekly blast of Baby Quasar is the best way to say g'bye to Howdy Doody I have found so far.


Purified water, caprylic/capric triglyceride, rye seed extract, butylene glycol, artemisia abrotanum extract, isohexadecane, BIS-PEG/PPG-14/14 Dimethicone, ethylene/propylene/styrene copolymer, cyclopentasiloxane, sodium hyaluronate, xanthan gum, tripeptide-1, saccharide isomerate, ethylhexyl palmitate, tribehenin, sorbitan isostearate, palmitoyl oligopeptide, oat kernel, squalane, stearic acid, glycerol stearate, cetyl alcohol, dimethicone, PEG-100 stearate, tocopheryl acetate (vitamin E), ascorbic acid (vitamin C), carbomer, disodium EDTA, diazolidinyl urea, iodopropynyl butylcarbamate, tromethamine.

  • November 8, 2011

    by Marta

    Spo, that's so good hear re the Sirius. So you are putting Lipofill on your lips, under Define - that's inspired.

  • November 8, 2011

    by spo

    I've been using this product with Sirius Aurora LED treatments (3x/wk) and I found excellent 'plumping' results on the nasolabial area.

    But what I wanted to post is that I had been experimenting with this for lip plumping effects.

    I use it under YBF Define 2-3 times a day, when possible. Again, maybe it's wishful thinking, but my lips have seemed fuller. No, maybe not wishful thinking, because my husband, without knowing anything, remarked that my thin lips looked fuller! :-D

  • September 21, 2011

    by Marta

    Hi Sofia, Chella's Master Protocol is very good, in the same vein, but nothing gluteny that I can see

  • September 21, 2011

    by sofia


    I was ready to try the Osmotics line for my nasal labial lines but then realized the products have wheat protein or rye seed extract. I am one of those who is gluten intolerant so I can't use either product.

    Could you suggest something else that works?


  • September 15, 2010

    by marta

    No L, its for nasal labial lines

  • September 15, 2010

    by L

    Does this help to plump the lips?

  • September 14, 2010

    by marta

    Hey Deborah, I am so pleased to hear that. I must say, I was doubtful that a cream could deal with puppet lines until I tried it. Glad you got good results.

  • September 14, 2010

    by deborah rodell

    Bought, used it, loved it!

  • July 28, 2010

    by Amy

    Hi Marta,

    Do you think this product would work on the deep vertical frown lines between my eyebrows? I really do not want to resort to botox or something more radical.


  • December 14, 2009

    by Greg

    It's now live in your TIA OpenSky store! Yay!

  • December 4, 2009

    by marta

    Susan, the effects did seem to last and I am back on using it again. Overall, I am very pleased with this product.

  • December 3, 2009

    by Susan


    Please, please report your results. :-)

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