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Perricone MD Cold Plasma

November 14, 2009 Reviewed by Marta 13 Comments
Dr Nicholas Perricone's latest potion is called Cold Plasma ($150) and has emerged from the lab after years of research. It is supposed to treat a depressingly long list of aging skin traits (10 in all), including wrinkles, elasticity and dryness.

Dr Perricone's secret sauce is phosphatidylcholine. This is a kind of phospholipid, which is in turn is a lipid. Lipids are a broad group of naturally-occurring molecules which includes fats, waxes, sterols, fat-soluble vitamins (such as vitamins A, D, E and K), monoglycerides, diglycerides, and, of course, phospholipids. The main biological functions of lipids include energy storage, as structural components of cell membranes, and as important signaling molecules.

Amongst phospholipids,phosphatidylcholine unique because of its shape. It has a choline 'head' (choline is in cell-signaling molecules) and a chain of fatty acids making up the 'tail'. Phosphatidylcholine for cosmetic use is created by isolating distinct components from egg yolks and natural soy beans.

Ever versatile, phosphatidylcholine is used in cellulite treatments, such as Lipolight and Lipodissolve, as it breaks down fat cells, injected to treat excess fat around the eyes (bulging eyes?) and to treat acne. It also helps other ingredients penetrate the skin and so should be used with caution when an ingredient in formulas that contain other questionable or toxic ingredients. In this case, that would be the preservative phenoxyethanol, which is an irritant and can attack the central nervous system.

However, there is not much evidence of what phosphatidylcholine does when applied topically. Furthermore, it seems to be difficult to include in potions because of stability and interaction with other emulsifiers. I did find one academic book that mentioned that it has good skin hydrating capabilities, but does not penetrate deep into the epidermis.

As you would expect from the salmon-loving Dr Perricone, Cold Plasma also contains docosahexaenoic acid (DHA), the fatty acid found in cold water fish. This is one of the main components of plasma  and harassed new mothers everywhere should note that, according to a study, the more there is in the plasma, the more likely the newborn baby is to sleep well. Other signature ingredients include DMAE and astaxanthin. Oligopeptide-17 is a neuropeptide that, like Argireline, inhibits the muscle movements that cause expression wrinkles.

I'm not yet completely sold on phosphatidylcholine, but the rest of the cocktail of quality antiagers, including Matrixyl 3000 make this worth checking out.

Ingredients in Cold Plasma

Aqua (Water), Glycerin, Tetrahexyldecyl Ascorbate, Phosphatidylcholine, Isopropyl Palmitate, L-Tyrosine, Butylene Glycol, Glyceryl Stearate, PEG-100 Stearate, Cetearyl Alcohol, Oligopeptide-17, Ceteareth-20, Magnesium Aspartate, Zinc Gluconate, Dimethyl MEA (DMAE), Docosahexaenoic Acid, Ascorbyl Palmitate, Phenoxyethanol, Dimethicone, Caprylyl Glycol, Glycolic Acid, Retinyl Palmitate, Saccaromyces Ferment, Elaeis Guineensis (Palm) Oil, Carbomer, Disodium EDTA, Tocotrienols, Copper Gluconate, Polysorbate 20, Sorbic Acid, Tocopherol, Sodium Hyaluronate, Acetyl Hexapeptide-8, Palmitoyl Oligopeptide, Astaxanthin, Palmitoyl Tetrapeptide-3
  • April 5, 2017

    by Sandra

    I tried the Perricone line a few years back, and had an allergic reaction.
    Does anybody have an idea what it was causing it?

    Thank you

  • January 4, 2015

    by Donna

    could you use on other areas besides your neck.? I'm an avon rep what would compare to cold plasma with the Anew skin care ?

  • December 29, 2014

    by Jennifer

    I believe the problems with his products is that there are so few actual actives in them. What antiaging ingredients there are are literally WAY down the ingredients list. How could it possibly work?

  • October 12, 2013

    by Annie

    Does anyyone know about Cold Plasma SUB-D, now advertised on TV with impressive-looking results. FOR the NECK. ??

  • September 18, 2013

    by Jane

    I tried it and it was awful so I tried the j bio growth factors and love it.

  • July 23, 2013

    by Rina

    I just started using this cream and I CAN"T Stand the smell OF IT.... after reading your review I now understand why I can't stand the smell of this cream.... it has fish in it.... the cream is grossing me out... now sure what to do.... UGH.. my face smells like fish. I HATE IT!!!!!

  • April 7, 2011

    by Noel

    I've been following this website intensely over the last few weeks as I am probably the most product-junkie 33 year old guy in existence. I have been using Cold Plasma for a while now, over a year now on and off ("while" being used comparatively speaking since a very and I mean VERY scarce few products can hold my attention longer than a month). The results are undeniable, brighter, firmer skin. Pores are definitely less noticeable. Although the price is obscene, I mentally justify it since I just love the results!

  • October 9, 2010

    by marta

    Hi Naomi, Cold Plasma is really aimed at 40-50 somethings. Take a look at some of the products that we have reviewed for 30-somethings:

  • October 8, 2010

    by Junko

    The smell of this is makes me sick to my stomach.
    I can't use it.

  • October 8, 2010

    by Naomi

    Hello. Can anyone advise me whether the ingredients in Cold Plasma work to prevent ageing of the skin? I am 29 years old and wondering whether this product is suitable for me? Regards.

  • July 20, 2010

    by Maria

    I love this product. I have seen an enormous difference in my skin. It is more radiant and hydrated.

  • July 9, 2010

    by Margo

    This is a ripoff, like all Perricone products. It didnt' work for anything. On the bright side, I did get a no-hassle refund.

  • January 31, 2010

    by Shannon

    All I can say is that I believe it is different and works. I've been using it 2 1/2 weeks an dI look 5 years younger. I'm not kidding! I've tried most of his other products with only mediocre results -- usually they are not worth dealing with the fish smell. However, with Cold Plasma, I actually see results in the texture and firmness of my skin.

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