My skin likes amino acids and when a serum is filled with them, as is Peter Thomas Roth Neuroliquid VoluFill Youth Serum ($120) with 19 amino acids plus peptides, my skin likes them very much indeed. Peter Thomas Roth Neuroliquid VoluFill promises to restore fullness and I found during my six week trial that it delivered.

I started by using it primarily on my jawline, chin and up to nasolabial lines where there is a little sagging (Ultra Renew Plus ($159) is a huge help, but I can always do with more). Within a few weeks, the area was looking fuller and I extended the test to include my forehead. I was impressed enough after my trial to continue using it and can now say that Peter Thomas Roth Neuroliquid VoluFill Youth Serum is part of my daily routine.

Neuroliquid contains the “VoluFill” complex at 96%. This includes the aforementioned 19 amino acids. Amino acids are the proverbial building blocks of the body, accounting for the smallest molecular components of proteins. Because proteins are involved in every major process in the body, amino acids are essential to health. Of the 20 amino acids found within proteins, 10 are manufactured by the body. The rest must be obtained from the diet and are thus called essential amino acids (arginine, histidine, isoleucine, leucine, lysine, methionine, phenylanine, theonine, tryptophan, and valine). Just to take one example from the essentials, arginine: it plays a pivotal role in cell division and the healing of wounds.

VoluFill also includes peptides, including palmitoyl tripeptide-5, otherwise known as Syn-Coll and supposedly more powerful than Matrixyl at boosting collagen and the immune defenses. There is also palmitoyl dipeptide-5 diaminobutyroyl hydroxythreonine, which as well as being a mouthful is also a collagen booster and is sometimes combined with another peptide to create an anti-aging active marketed as Syn-tacks.

Peter Thomas Roth keeps the peptides coming with acetyl tetrapeptide-9. This is a relatively new peptide. There are protein-sugar (glycosaminoglycan chains) complexes that are involved with collagen fibers and acetyl tetrapeptide-9 targets one in particular, called lumican. Hexapeptide-2 is a skin-brightening peptide that works as an antagonist to MSH, binding to its receptors, thereby decreasing melanin synthesis.

At the cutting edge is Syn-Hycan I recognize at least the main component of it in the ingredients list and it may be responsible for Peter Thomas Roth Neuroliquid VoluFill’s lifting effect as it was designed to tackle sagging skin.

Overall, this is an impressive formula, mercifully free of extraneous fillers that merely waste our money and the only things to dislike are the usual suspects in the preservative department. A winner.

Ingredients in Peter Thomas Roth Neuroliquid VoluFill Youth Serum: Proline, Threonine, Serine, Arginine, water/aqua/eau, Isoleucine, Glycine, Glycerin, Lysine, histidine, Leucine, Acetyl Hydroxyproline, Glutamic Acid, Aspartic Acid, Alanine, Tyrosine, Methionine, Phenylalanine, Isopropyl Myristate, Palmitoyl Tripeptide-5, Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine, acetyl Tetrapeptide-9, Hexapeptide-2, Soluble Collagen, Cysteine, Valine, Glutamine, Sodium Hyaluronate, Sodium Pca, Butylene Glycol, Diphenylsiloxy Phenyl Trimethicone, Ethylhexylglycerin, Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate, Polymethylsilsesquioxane, Soy Amino Acids, Algae Extract, Yeast Extract, Acacia Seyal Gum Extract, Propylene Glycol, Pentylene Glycol, Trideceth-9, Peg-40 Hydrogenated Castor Oil, Sodium Borate, Mica, Phenoxyethanol, Sodium Benzoate, Potassium Sorbate.