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Products that contain matrixyl 3000

Reviewed by Marta January 26, 2008 19 Comments

The other day I posted a What Is It? on matrixyl and matrixyl 3000. They are both peptides, but based on very different ones. Matrixyl 3000 is based on two peptides and there is some evidence that it might be more powerful as an anti-aging ingredient than the original matrixyl. All the background can be read by clicking here. A number of you have been searching for products that contain matrixyl 3000. Here is a quick summary of the ones that I have found. But reader beware, they are not all that they seem to be.

First is MyChelle Supreme Polypeptide Cream. What I like about this matrixyl 3000 cream is that every ingredient is clearly identified and its purpose described. There is nothing nasty in it and, in fact, its chock full of good anti-aging ingredients.

On the other hand, you could accuse this cream of hedging its bets since it also stuffs in anti-oxidants, moisturizers and retins. It might all prove a bit much. Nevertheless, worth a try and not at all badly priced at $49.

Peter Thomas Roth's Un-wrinkle Night Creme has all the hallmarks of why I don't like his products. They always seem faddish to me, as if they just hopped off the latest bandwagon. Unwrinkle Night Creme has 3% matrixyl 3000 (give him credit for owning up to the amount when few others do). It also has no less than three ingredients that are supposed to freeze the facial muscles. These are superficial and short term at best. One of them is even snake oil. Well, venom. Its called syn-ake and you can read more about it here.

I have a similar issue with Bellaplex. As well as matrixyl 3000, this contains argireline - a acetyl-hexapeptide-3. Like the snake venom, this temporarily freezes the facial muscles. Plus, I have come across a fair number of consumer reviews of Bellaplex that have been disappointed.

Isomers Matrixyl 3000 Rejuvenation Serum is, on the other hand, pretty much unadulterated.

I'm not sure I like the faux pharma packaging of Isomers and, in my experience, products that come with a dropper top are a bit messy to use. Anyway, its well priced at $49 and it doesn't have any other rubbish in it.

I thought I might be on to something with Dermapril-SP. This claims to contain matrixyl 3000. However, the ingredients list mysteriously only refers to plain old matrixyl. Perhaps they forgot to update the website. At best that's sloppy; I'll be giving Dermapril-SP a miss. UPDATE: 6/6/2008 detailed review of Dermapril and comparison to Mychelle. Click here.

My advice is to scrutinize products claiming to be matrixyl 3000 based as carefully as possible before committing to one. Make sure it is matrixyl 3000 and that it doesn't have other stuff in it that you don't want to use or you know to be mostly a waste of time. There is only so much we should be assaulting our pores with.

See all our FIVE BEST recommendations including Five Best for sagging skin, Five Best with vitamin C and Five Best eye creams

  • September 10, 2014

    by colby

    Good Evening Marta, I enjoy your site immensely. I have often seen you mention Isomers products but you never recommend them, am I wrong?

  • June 18, 2012

    by James

    To clear up confusion ... when you see products like Matrixyl 3000 labeled with concentrations that look higher - such as 15%, 20%, 30% etc - it is just a different way that the chemists sometimes refer to it, so just move the decimal to the left one place. So, 20% = 2%.

    So technically, with the most research that has come from Sederma, they recommend around 4% now (which you might see as 40%). Hope that helps.

  • September 11, 2011

    by Laura

    My mother recently started selling BECOME facial products...I have tried them and so far I love them! They are wonderful. If you think you might be interested...check out thier website or contact a local consultant. I live in Thomasville NC and there are only two women in the region that sells it. It is wonderful products at resonable prices. You should try it today! They have Matrixyl 3000 in their line of products. Have a blessed day ! Laura

  • February 20, 2011

    by jennifer

    I read online that sederma the company that conducted the clinical trial on matrixyl 3000 used a 4 per cent solution and have advised it operates effectively within the range of 3 and 8 per cent of a finished product. Using a product with more than 8 per cent might be the reason why some products arent effective perhaps. I've yet to try the product myself, but have ordered an organic eye cream with 3.3 per cent matrixyl 3000 to see if it'll help with eye bags. I've also contacted sederma to get clarification about how much matrixyl 3000 should be in a product for it to be effective.

  • May 24, 2009

    by Camila

    Hello Marta, nice to meet you, Ihave been testing an dusing some rejuvenating porduct, such as viterol (viatrozone gel with retinol) from DS Laboratories, N.V. Perricone (a quite expensive products in my opinion), the one that youpemnyioned brande with Peter Thomas Roth and some product with Matrixyl3000, in fact; recently I bought a matrixyl serum on ebay (from "free" distribution, no labeled or branded i think)that refers have 20% concentrated Matrixyl3000, pretty much concentrated than other fromulas o serums, Can it be possible? Honestly speaking, I noticed a favorable difference in appereance, firming, thighness that makes me be amazaed at this time, however, frecuently I feel that my skin is a little bit more oily in comparison when I used Viterol. What can I do? what porduct is the best in deed? PLS HELP ME

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