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Products that contain Syn-tacks

Is a Solution for:
Sagging Skin
November 1, 2008 Reviewed by Marta 16 Comments
Syn-tacks may be the new anti-wrinkle peptide to give Matrixyl 3000 a run for its money. According the company that makes Syn-tacks, it stimulates a broad spectrum of things responsible for youthful skin - laminin V, collagen types IV, VII and XVII and integrin - all at once. It is relatively new on the cosmetic scene and can be found in not much more than a handful of leading edge products. Like Matrixyl 3000, Syn-tacks is made from two synthetic peptides, so look out for palmitoyl dipeptide-5 diaminobutyroyl hydroxythreonine and palmitoyl dipeptide-6 diaminohydroxybutyrate. I've rounded up a few potions with Syn-tacks that look promising. Do write in with any good finds that I've missed.

Arcona Peptide Firming Complex Regenerate AM/P ($72). This product by Arcona looks as if it could pack a powerful punch. Rarely have I seen so many peptides in one bottle. In addition to Syn-Tacks, there is Syn-Coll, a tripeptide and thymulen 4, a peptide that is supposed to boost the immune defenses. There is also epidermal growth factor and, for good measure, some pea extract. Arcona goes out of its way to avoid unpleasant things such as parabens so there doesn't seem to be anything to dislike.


M Lab Anti-aging Blemish Control ($175). M Lab's products always make me feel a little dizzy. In Anti-aging Blemish Control there is an ingredients list as long as your arm (I counted over 70) and our friend Syn-tacks is in there somewhere. The question I have with M Lab is whether so many goodies can be crammed into one bottle without minimizing the concentrations to the point where they can barely be effective. The M Lab philosophy is the ingredients are synergistic and combine together to do their magic. I remain a little skeptical, but we did have a positive reader review of an M Lab product.

The other problem with there being so much stuff is that it is easy to overlook the ingredients that I'd rather not come into too much contact with: sodium benzoate (which kills off DNA and is carcinogenic if it gets mixed up with vitamin C; plus chlorphenesin and phenoxyethanol (irritants and much worse if ingested).

Canyon Ranch Age Transforming Concentrate Serum ($150). The upmarket spa that is Canyon Ranch launched its anti-aging cosmetic line a few months ago. Its signature ingredient is niacin (vitamin B) that is time-released. But I was interested to see that Transforming Concentrate focuses on Syn-tacks and ceramides. Although Canyon Ranch's formulator isn't quite is manic as the one over at M Lab, there is a bit of a everything but the kitchen sink vibe going on here too. Still, there are plenty of good botanicals in the mix.

RTOV Intensive Facial Lift Stimulator ($48). As well as Syn-tacks, RTOV has added in a handful of other peptides. One of them, trylagen, is all about collagen. It stimulates collagen synthesis and it "organizes" the collagen, by which is meant that it uniforms their diameter and spaces them
regularly to make the skin more supple. This potion also has
pseudoalteromonas ferment extract. This is a strain of bacteria from the Antarctic and researchers in Barcelona say that it is exceptionally good at retaining moisture. The usual suspects in the preservative department, but otherwise this looks interesting.


Isomers Stem Genesis ($75). I must say that I am beginning to feel rather remiss for not having got better acquainted with Isomers. They make simple, intelligent products. The latest is Stem Genesis and this may be the one that I should get to know. Using a technology that was invented to cultivate apple stem cells, the ingredient called malus domestica fruit cell culture, is supposed to reduce the appearance of wrinkles in four weeks. There are a couple of vitamin Cs, tiger nut (for skin elasticity), an alga and the anti-radical tripeptide 10. Oh, and there's Syn-tacks

Ingredients in Arcona Peptide Complex

Aqua, Pisum Sativum (Pea) Extract, Hydrolyzed Myrtus Communis Leaf Extract, Dextran Complex, Acetyl
Tetrapeptide 2 (Thymulen 4 Pentapeptide), Palmitoyl Tripeptide 5 (SYN-Coll Tripeptide), Diamino Butyloylhydroxyehreonine (Syn-tacks Peptide),
Epidermal Growth Factor, Palmityol Dipeptide, L-Sodium Hyaluronate, Diaminohydroxytbutyrate, Mica.


Ingredients in M Lab Blemish Control

Aqua (Water), Montmorillonite, Glycerin, Argania Spinosa Kernel Extract, Pentylene Glycol, PPG-14 Butyl Ether, C12-15 Alkyl Ethylhexanoate, Butylene Glycol, PEG-40 Stearate, Cetearyl Alcohol, Sesamum Indicum (Sesame) Seed Extract, Serenoa Serrulata Fruit Extract, Squalane, Oligopeptide-10, Magnesium Aluminum Silicate, Caprylyl
Glycol, Cholesterol, Salicylic Acid, Xanthan Gum, PEG-60 Almond Glycerides, Chlorphenesin, Oleanolic Acid, Ceteth-10 Phosphate, Palmaria Palmata Extract, Dicetyl Phosphate, Nordihydroguaiaretic Acid, Vaccinium Myrtillus Fruit/Leaf Extract, Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine, Acer Saccharum (Sugar Maple) Extract, Saccharum Officinarum (Sugar Cane) Extract, Palmitoyl Dipeptide-5 Diaminohydroxybutyrate, Carbomer, Citrus Aurantium Dulcis (Orange) Fruit Extract ,Citrus Medica Limonum (Lemon) Fruit Extract, 1,2-Hexanediol, Hydrolyzed Algin, Algae Extract, Artemisia Vulgaris Extract, Dimethylacrylamide / Acrylic Acid/Polystyrene Ethyl
Methacrylate Copolymer, Potassium Sorbate, Chlorella Vulgaris Extract, Sea Water (Maris Aqua), Urea, Sodium PCA, Disodium EDTA, Ubiquinone, Tetrahexyldecyl Ascorbate, Tocopheryl Acetate, Hydroxypinacolone Retinoate, Retinyl Palmitate, Epilobium Fleischeri Extract, Phenoxyethanol, Polyquaternium-51, Trehalose, Sodium Benzoate, Boswellia Serrata Extract, Oryza Sativa (Rice) Bran Extract, Mel Extract, Methylisothiazolinone, Butylphenyl Methylpropional, Sodium Hyaluronate, Triacetin, Tropolone, Linalool, Alpha-Isomethyl Ionone, Amyl Cinnamal, Hexyl Cinnamal, Aspalathus Linearis Leaf Extract, Camellia Oleifera Leaf Extract, Citronellol, Limonene, Benzyl
Salicylate, Hydroxycitronellal, Geraniol,Hydroxyisohexyl 3-Cyclohexene Carboxaldehyde, Fragrance (Parfum).


Ingredients in Canyon Ranch Age Transforming

Water (Aqua/Eau) ,Cyclopentasiloxane, Myristyl Nicotinate, Butylene Glycol, Glycerin, PPG-3 Benzyl Ether Myristate, PEG-40 Stearate, Soybean (Glycine Soja) Extract, Ethylene/Acrylic Acid Copolymer, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Dimethicone, Glyceryl Polymethacrylate, Silica, Isohexadecane,
Palmitoyl Dipeptide-5 Diaminobutyloyl Hydroxythreonine, Palmitoyl Dipeptide-6 Diaminohydroxybutyrate, Palmitoyl Oligopeptide, Ceramide 2, Hydrogenated Lecithin, Lycium Chinense Fruit Extract, Vaccinium, Angustifolium (Blueberry) Fruit Extract, Arctostaphylos Uva Ursi Leaf Extract, Acrylamide/Sodium Acryloyldimethyltaurate Copolymer, Sodium Hyaluronate, Lecithin, Hydrolyzed Wheat Gluten, Ceratonia Siliqua (Locust Bean) Gum, Aloe Barbadensis Leaf Juice, Triticum Vulgare (Wheat) Germ Extract, Saccharomyces Cerevisiae Extract, Cola Nitida
Seed Extract, Paullinia Cupana Seed Extract, Ilex Paraguariensis Leaf Extract, Panthenol, Caffeine, Octyldodecanol, Tocopheryl Acetate, Retinyl Palmitate, Arachidyl Propionate, Ethyl Linoleate, Ethyl Linolenate, Polysorbate 80, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Fragrance (Parfum), Aminomethyl Propanol, Chlorphenesin,
Disodium EDTA, Phenoxyethanol, Caprylyl Glycol, 1,2-Hexanediol, Tropolone, Potassium Sorbate Benzyl Benzoate, Limonene, Hexyl Cinnamal, Butylphenyl Methylpropional Linalool.

Ingredients in RTOV


Aqua (Water), Argireline® (Acetyl Hexapeptide-8), Cetearyl Olivate (and) Sorbitan Olivate,C12-15 Alkyl Benzoate, Cetyl alcohol, Propylene Glycol USP, Trylagen™ PCB (Pseudoalteromonas Ferment Extract, Hydrolyzed Wheat Protein, Hydrolyzed Soy Protein, Tripeptide-10 Citrulline, Tripeptide-1, Lecithin, Xanthan Gum, Carbomer, Triethanolamine, Phenoxyethanol, Butylene Glycol, Caprylyl Glycol),  Allantoin, Blackberry Seed Oil, Glycerin, Green Tea (Camellia Sinensis Leaf Extract), L-Ascorbic Acid (Vitamin C),Tocopheryl Acetate (Vitamin E), Syn®-Taks (Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine, Palmitoyl Dipeptide-5 Diaminohydroxybutyrate), Germall® Plus (Propylene Glycol (and) Diazolidinyl Urea (and) Iodopropynyl Butylcarbamate), Rosemary Oleoresin, Triethanolamine hanalomine.

Ingredients in Isomers Stem Genesis

Aqua/Water, Malus Domestica Fruit Cell Culture, Xanthan Gum, Glycerin, Lecithin, Tripeptide-10 Citrulline, Cyperus
Esculentus Tuber Extract, Erythritol, Homarine HCl, Acetyl Tetrapeptide-9, Ascorbyl Glucoside, Pamitoyl Dipeptide-5, Diaminobutyloyl Hydroxythreonine, Palmitoyl Dipeptide-6 Diaminohydroxybutyrate, Sodium Hyaluronate (LMW), Sodium Hyaluronate (HMW), Magnesium Ascorbyl Phosphate, Phenoxyethanol, Tropolone,
Carbomer, Triethanolamine.

  • June 28, 2013

    by Marta

    Hi Alexandra
    Palmitoyl is not palm oil, it is a derivative of palmitic acid, a saturated fatty acid

  • June 28, 2013

    by alexandra

    Question does the Palmitoyl refer to palm from Malaysian Palm farms?

  • January 16, 2013

    by Sarah

    Mad Hippie face cream has both Matrixly 3000 and Syn-tacks at about $26 for about an ounce

  • January 14, 2012

    by James

    Societe Medical Skincare has just released a new product that not only has the Syn-tacks in it but they include the new anti wrinkle peptide Syn-ake. This is a professional line worth looking at.

  • November 8, 2009

    by Vivian

    I just want to share this information that is available at www.fda.gov relating to cosmetics labeling. For ingredients that are present at less than 1%, these ingredients may be listed in any order. Most companies are in error listing ingredients that are used as mixtures (which the peptides are). This is wrong -"Proprietary mixtures of ingredients identified in the ingredient dictionary by a parenthetical "(and)" are often declared on the label as shown in the dictionary section listing chemical/trade names and their respective label names." This is the correct way - "The compounds of such mixtures must be separated, the "(and)" omitted, and the components treated as individual ingredients for labeling purposes." The supplier of the mixtures must supply the concentrations of the individual components for the manufacturer of the cosmetic product to comply with this requirement. The peptides normally come as 1% solutions and the suggested use is usually between 1 and 8%. If the suppliers' suggested use level is followed, then the concentrations of the peptides can never be more than 1% and they can be listed immediately below the ingredient present at 1%. What is important to know is at what level were the clinicals for the peptide done where it showed optimum activity. This is the level where below it the peptide will show significantly lower efficacy and above it the increased efficacy does not warrant the increased cost.

  • October 3, 2009

    by Vincent

    The latest technology to be released this October is Coming From Radiance New York.
    What I like is the Honesty in label ingredients and the percentage of the main drivers. More than Peter Thomas Roth and Paraben free. I'm told it will be significantly less than the competitors and better performance. This I like!

  • May 7, 2009

    by Colleen

    All of this is helpful. I found this site looking up ingredients in skincare I use and some I just started using.

    I rarely find products I use on websites like this but this is helping me make better decisions. I just bought Serious Skin Care Replicate and Renew serum which has malus domestica fruit cell culture. I cannot tell what percentage, but at least it is not listed in the last five ingredients. Just received it yesterday, so don't know how I like it yet.

    I do use Serious Skin Care Serum No.8 and have seen very notable results without irritation or breaking out. Particularly has worked well around eyes and mouth. I am not a chemist of any sort and don't remember the ingredient list; but, I think it is a knock-off of No.7 (can't remember who makes that!!).

    I buy the SSC products from HSN. I do read the ingredient list and try to understand why I am using a particular product. This is why I appreciate the work on this website and all the posts. Please don't stop!

    I am 55 and recently my grandnieces were overheard guessing ppl's ages. They guessed I was 42. I'll take it!

    I can afford products bought in kits from HSN.....also gives me a chance to experiment with more variety than I otherwise could buy. I never could tolerate Neutrogena products for some reason and couldn't afford to keep trying other such products which couldn't be returned. Electronic shopping allows products to be returned and that saves me, too.

    Not intending to sound like a commercial. Would love to hear what you think of the products I listed above.....no pressure, no expectations......just grateful for your site and posts.

  • April 22, 2009

    by Debbie

    First of all let me state that I am a biochemist and have dedicated much of my time over the past few years helping people decipher product labels, fraudelent claims in the skin care field and recommending actives that actually work from companies that are responsible enough to tell me (or better yet, list on their website or label) the % of active ingredient.

    I was totally thrilled to stumble across this website and have great admiration for the goals of the owners, but I still see manily products that have no proof of efficacy being listed as "best", etc.

    From the products above, I would not consider anything but the Arcona and Isomers...BUT.....neither are great.

    The Arcona is "clean" and has a few decent actives (but still only those that are relatively new and unproven scientifically), but as one person already commented, how much SynTacks, SYN-Coll and EGF are in this product? I expect to get 2.5 -3% SYN-Coll or what is the point? Since the first 3 ingredients are not "actives" per se, they could account for 95% of the product, making it a waste of money.

    What is truly helpful on a website such as this is to post the levels of actives that were used in clinical trials that obtained real results on human skin (not company sponsored studies featuring women who felt their skin was smoother and such dribble as it is useless due to subjectivity) and then research each featured product to find out if it contains effective levels of actives.

    From my gut, the Arcona is a better collagen stimulating peptide formula than the Stem Genesis. The Stem Genesis seems to be featuring one of the latest additions to the active market, Malus Domestica fruit cell culture. There is some Decorinyl (Tripeptide-10 Citrulline) thrown in for good measure.

    So, in fact, these two serums compliment each other, rather than compete with each other.

    To clear up some scientific inaccuracies:

    1) The Syn-Tacks peptide is actually written as such: "Palmitoyl Dipeptide-5 Diaminobutyloyl Hydroxythreonine (and) Palmitoyl Dipeptide-6 Diaminohydroxybutyrate". I know it is a mouthful. If you read the Arcona ingredient list, the make it look like they have other peptide ingredients in the product by splitting the name into three random parts separted by the HA and the EGF! I hope they were just naughty, not that they did not know better. ;-)

    2) The Canyon Ranch product does not include cermaides per se, but actually features a Sederma active called Dermaxyl. It is a combination of Pamitoyl Hexapeptide 9 (which as many manufacturers do is listed as simply palmitoyl oligopeptide) and Ceramide -2.

    3) Expanding upon #2, the definition of oligopeptide: "An oligopeptide (oligo-, "few") consists of between two and twelve amino acids. (includes dipeptides, tripeptides, tetrapeptides, pentapeptides, etc.)" Thus, no one peptide has a monopoly on this name. People used to confuse this term with the true INCI name for Sederma's Matrixyl and now it is used interchangably with the Sederma's Biopeptide-CL (PAL-GHK) that makes up part of Matrixyl 3000 (the other part being Rigin, or chemically, Palmitoyl Tetrapeptide-7) .

    BTW: Isomers post on their own website (by scientisits) that Matrixyl 3000 is made up of palmitoyl oligopeptide, Biopeptide-CL and the tetrapeptide. Hello? Look on your own labels! Two of those things are one in the same! :-)))))

    Consumers need to start challenging false claims, labelling laws and companies that refuse to list at least the % of the key actives in their products. Otherwise the multi-billion dollar beauty business will continue to offer little of significance except a drain on our already strained bank accounts.

    Anyone looking for a very clean and potent formula based on the apple extract used in Stem Genisis, look no further than the $25 per ounce serum formulated by the chemist famous for the available research. I am not sure if links or recommendations are allowed but here is the ingredient list:

    Ingredients: Chondrus crispus (seaweed) extract, purified water, hyaluronic acid, malus domestica fruit cell culture, xanthan gum, glycerin, lecithin, pheoxyethanol, ethylhexyglycerin.

    *Note that the hyaluronic acid which as sodium hyaluronate would only be present at an absolute maximum of 1% is listed as a the liquid solution (% unknown) and in no way means there is less than 1% malus domestica fruit cell culture in the product.

    I have absolutely NO issue with pheoxyethanol, either in this product, the Isomers product or any other product. The worry about it is over-hyped..and this comes from a die-hard when it comes to clean products!

    Chris & Julie Kay,

    I am not a big fan of MyChelle. Their products and marketing is deceptive in it's own way. Natural is not necessarily better. "Natural" is a marketing gimmick to trick people into thinking that natural extracts are better for human skin than man made actives. Nothing could be further from the truth. Most of the strongest irritants are natural plant extracts and almost all of the actives that can actually change your skin without surgery are synthesized.

    But to answer your question, Julie, true spin trap at the correct percentage in a suitable formulation acts like an antioxidant (but in a different manner). Instead of neutralizing free radicals like other antioxidants, spin traps can suppress gene transcriptional factors. Spin traps work by capturing free radicals and redirecting them to support beneficial tissue respiration instead of destroying cellular DNA.

    Hope some of that was helpful.

  • March 6, 2009

    by Sharina

    I personally use the Isomers Stem Genesis. For me there is absolutely no skin irritation. I used to have extremely sensitive skin on my face and some scattered rosacea. Since using the Isomers line now about 7 years I have noticed an even more remarkable difference in my skin since using Stem Genesis. The main area for my concern was around my eyes. Under my left eye I had terrible criss-cross lines. After one application I noticed that the area appeared much smoother by day's end. Mind you no product had ever done that for me. Over time all the lines around my eyes, nasal labial and jaw line have continued to show improvement. As well as a lifting effect in these same areas. I will never be without this product. I stock up when its on sale! You should too!

  • February 26, 2009

    by Julie Kay

    Mychelle's Pumpkin renewel creme is nice and contains spin-trap (a little off topic, here =/ ). What I'd like to know is how much spin-trap in a lotion makes a difference to how it performs. ~jk

  • February 26, 2009

    by Chris

    MyChelle has amazing and non-toxic products. The Supreme Polypeptide Cream and the Notox Serum are the 2 that come to mind.

  • February 8, 2009

    by Romira

    IF Isomers is following the legal way to list ingredients in order of most being first, then there is NOT much in their forlulation if Xantham Gum is listed as the 'third" ingredient after the water and fruit extract.

    I say the above simply because Xanthan Gum is almost never put into a formulation above 0.03 or 0.05 % per weight. It is used to thicken a product as well as give it better slippage/spreadability. If that is the case, then what exactly is in that product at the microscopic percentages apparently used?

    The same can be said about all the above formulations.

    Its, yet again, glaring examples of what I would call "freudulent" expressions of their products and their contents passing them as effective in their claims.

    M Lab Blemish Control is a total joke.

    The ONLY one that even comes close to being acceptable from this list is Arcona.

    What is needed is an honest to goodness HONEST product and one that will make it clear to the consumers that it is NOT a panacea or a trip to the plastic surgeon. However, that under the parameters of a skin care serum/cream, that it will perform adequately if not miraculously within that context.

    Now that would be HONESTY! I wonder how many would purchase such a product that extolls its virtues of percentages that actually do help and does not hype it as a "miracle"?

  • November 6, 2008

    by Marta

    <p>The Arcona doesn't have anything harmful in it. Isomers has phenoxyethanol, troperlone and triethanalomine that could all irritate. I'll be reviewing Arcona in detail in a few weeks. </p>

  • November 6, 2008

    by Petra

    <p>So which product do you think is most effective between the Isomers Stem Genesis and the Arcona Peptide Complex? They both seem to have pretty good natural ingredients, but I'm wondering how you know if one is more potent and effective than the other? I'm also wondering what are the possible harmful ingredients in these? </p>

  • November 1, 2008

    by Marta

    <p>Apart from the Arcona (as far as I can tell). And I'll definitely investigate some of those other new ingredients. </p>

  • November 1, 2008

    by Stan

    <p>Syn-tacks sounds interesting, but unfortunately each of these products contain some harmful ingredients. Some are new and could be added to the 'What is it" section. It would be nice to look at each product in more detail.</p>

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