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Anti-aging products that address Nobel-winning telomeres

October 15, 2009 Reviewed by Marta 14 Comments

Telomeres were recently popularized - and legitimized - by a Nobel Prize winning team of scientists. Research on telomeres and aging has led to an ingredient called teprenone (sometimes marketed under the name of Renovage) cropping up in anti-aging potions and lotions.

So how do telomeres work? If DNA is broken there are two options after the cell cycle is stopped: Repair or death. If cells divided without telomeres, they would lose the end of their chromosomes, and the necessary information it contains. They are often described as being like the tips on the ends of shoelaces that stop them unraveling. Telomeres shorten every time a cell divides. When they become very short, they trigger cell crisis and cell death. As we know, cells can only replicate a limited number of times – a phenomena called the Hayflick Limit. There’s more on telomeres in an article posted last August.

In cosmetics, the objective not to lengthen the teleomeres, stabilize them so that at least they won’t shorten. Maintaining telomere length extends, we are told, the Hayflick Limit by one third. Renovage (made by the people behind Matrixyl) aims to do just that.

We have rounded up products that contain teprenone, ranging from cleansers to eye creams and body lotion. Some we have already covered on Truth In Aging, such as Skinn Wrinkle Night Balm, Jack Black's Protein Booster, YBF's new Boost. and Babor. There are also some new finds as well. Click on the images for details.

Ingredients In Jack Black Protein Booster Serum: Water, Glycerin, Sodium Polystyrene Sulfonate, Caprylic/Capric Triglyceride, 1, Sorghum Bicolor Stalk Juice, Palmitoyl Oligopeptide, Palmitoyl Tetrapeptide-7, Teprenone, Dipeptide Diaminobutyroyl, Linum Usitatissimum (Linseed) Seed Oil*, Camellia Sinensis (Green Tea) Leaf Extract*, Plantago Lanceolata Leaf Extract**, Sodium Hyaluronate (L), Taurine, Tocopherol (D-alpha), Retinyl Palmitate, Ascorbyl Palmitate (L), Simmondsia Chinensis (Jojoba) Seed Oil*, Aloe Barbadensis Leaf Juice*, Pelargonium Graveolens (Geranium) Flower Oil, Anthemis Nobilis (Chamomile) Flower Extract, Rosmarinus Officinalis (Rosemary) Leaf Oil, Lonicera Caprifolium (Honeysuckle) Flower Extract, Lonicera Japonica (Honeysuckle) Flower Extract, Cocos Nucifera (Coconut) Oil*, Zea Mays (Corn) Oil, Glycine Soja (Soybean) Oil, Citric Acid, Hamamelis Virginiana (Witch Hazel) Water, Xanthan Gum, Potassium Sorbate, Butylene Glycol, Carbomer, Polysorbate 20, Benzylamide Diacetate, Caprylyl Glycol, Phenoxyethanol. *Certified Organic.

Ingredients in Skinn Wrinkle Night Balm (dry-normal): olea europaea (olive butter), butyrospermum parkii (shea butter), prunus amygdalus dulcis (sweet almond butter), glycine soja (soybean) sterols, santalum album (sandalwood) wood extract, phellodendron amurense bark extract, hordeum distichon (barley) extract, caprylic/capric triglyceride and teprenone (Renovage™), bisabolol, dioscorea villosa (wild yam) root extract, C12-15 alkyl benzoate and tribehenin and ceramide 2 and PEG-10 rapeseed sterol and palmitoyl oligopeptide (Dermaxyl™), caprylic/capric triglyceride and spilanthes acmella flower extract (Gatuline Intense™), phaseolus lunatus (green bean) extract, solanum lycopersicum (tomato) extract, lavandula spica (lavender) flower oil, superoxide dismutase, thioctic acid, linoleic acid, tetrahexyldecyl ascorbate, morinda citrifolia (noni) seed oil, tocopherol acetate (vitamin E)

Ingredients in Dermasilk: Aqua, glycerin, butylene glycol, caprylic/capric triglyceride, ethylhexyl palmitate, cetearyl alcohol, cyclopentasiloxane, dimethicone, glycol stearate, stearyl alcohol, mannitol, Butyrospermum parkii (shea butter), steareth-2, ascorbyl phosphate, tocopherol, retinol, Panicum miliaceum (millet) seed extract, hydrolyzed vegetable protein, Chlorella vulgaris extract, Avena strigosa seed extract, Phaeodactylum tricornutum extract, Waltheria indica leaf extract, Crithmum maritimum extract, ferulic acid, teprenone, adenosine triphosphate, sodium chondroitin sulfate, lecithin, cetearyl glucoside, steareth-21, guar hydroxypropyltrimonium chloride, xanthan gum, pentylene glycol, hydrogenated vegetable oil, polysorbate 20, dextrin, sodium gluconate, citric acid, sodium citrate, alcohol, phenoxyethanol, caprylyl glycol, tannic acid

Ingredients in Babor: Water (aqua), Prunus Amygdalus Dulcis (Sweet Almond) Oil, Aloe Barbadensis Leaf Juice, Caprylic/Capruc Triglyceride, Butylene Glycol, Polyglyceryl-6 Stearate, Squalane, Sorbitol, Ethylhexyl Isononanoate, Panthenol, Phenoxyethanol, Dimethicone, Cetearyl Alcohol, Fragrance (Parfum), Xanthan Gum, Ethylhexyglycerin, Carbomer, Teprenone, Potassium Sorbate, Alcohol, Triticum Vulgare (Wheat) Protein, Sodium Cetearyl Sulfate, Biosaccharide gum-1, Butylphenol methylpropional, Disodium EDTA, Hydoxylisohexyl 3-cyclohexene Carboxaldehyde, Avena Sativa (Oat), Kernel Protein, Linalool, Limonene, Pantolactone, Geranniol, Ascorbyl Palmitate, Citric Acid, ethylparaben, Ascorbic Acid, Sodium Benzoate, Butylparaben, Ethylparaben, Isobutylparaben, Propylparaben, Orange 4 (CI 15510).

Ingredients in CSI Telomer: Purified water, squalane, hyaluronic acid, caprillic/capric triglyceride, teprenone, polyacrylate 13, polyisobutene, polysorbate 20, xylitylglucoside, anhydroxylitol, xylitol, phenoxyethanol and ethylhexylglycerin.

Ingredients in Isomers Renovage for Body: Aqua/Water, Cetearyl Olivate, Sorbitan Olivate, Caprylic/Capric Triglyceride, Teprenone, Ilex Paraguariensis (Leaf) extract , Butylene Glycol, Coffea Arabica (Coffee Seed) Bean Extract, PEG-60 Almond Glycerides, Glycerin, Cetyl Hydroxyethylcellulose, Coco-Glucoside, Caprylyl Glycol, Alcohol, Glaucine, Cetyl Palmitate, Sorbitan Palmitate, Glycerin, Oryza Sativa (Rice) Extract, Caffeine, Phenoxyethanol, Tropolone.

Ingredients in Medik8 Red Alert Cleanse: Aqua, Cocamidopropyl Betaine, Sodium Cocoamphoacetate, Coco Glucoside, Decyl Glucoside, Glycerin (Veg), Caprylic/ Capric Triglyceride, Teprenone, Phytonadione, Citrus Aurantium Dulcis (Sweet Orange) Oil, Sucrose, Acacia Farnesiana Gum, Potassium Sorbate, Sodium Benzoate, Benzyl Alcohol, Quillaia Saponaria, Yucca Vera, Citric Acid, Limonene, Linalool, Citral

  • October 12, 2016

    by Hilda

    There is a lot of hype and greed involved in Skincare lotions and.
    Women chasing after youthful appearance contribute to unqualified claims and unjustified prices. If a one Oz bottle contains dozens ingredients with active on the bottom, how much good will it do?

  • September 7, 2016

    by Vikki

    Hi I'm 47 but as a smoker and sun worshipper I could easily pass for 55/60. Is there anything I can use?

  • June 8, 2016

    by Betty

    Do any of these products and serums have an impact on the dark almost bruised looking circles under some of our eyes ?

  • February 6, 2016

    by Marta

    Hi LisaAnn, that is a good question and the issue is obviously complex. The active mentioned in this article stabilizes the telomeres and is not actually multiplying cells. When we look at stem cells and growth factors it is striking how precise the signalling from one protein to another. For example, FGF1 signals FGF2 to get on with fibroblast growth and collagen production and is also responsible for keratinocyte resulting in rejuvenated skin. Although there isn't much research on their cosmetic use, there's a ton about how they are safely used for wound healing. There's more here:

  • February 5, 2016

    by LisaAnn

    Is it possible that products claiming to grow new skin or have the ability to start cell division contribute to or maybe even cause the growth of tumor cells, cancer, other biological abnormalities like hormonal issues? If they turn on cell growth wouldn't that have to be all, how could it be selective in the growth?

  • October 7, 2015

    by Einat

    Hi :), I'm a 35 years old woman, with combination skin, a bit of hormonal adult acne (non notiecable) and some fine lines. which products are best suited for me?

  • September 16, 2015

    by Marta

    Hi Hayley, of the products mentioned here Your Best Face Boost is suitable for sensitive skin. And Your Best Face Correct is a great firming eye cream that has teprenone:

  • September 15, 2015

    by Hayley

    Anything good for sagging upper eyelids? Also which product is best for the face if suffer from sensitive skin and outbreaks please?

  • June 20, 2015

    by Terri

    Lydia, the best product I have found for puffy eyes is Skinfinite LOL Eye Serum. It is in the TIA shop and a good buy at $45.

  • June 19, 2015

    by lydia a

    any good creams for eye puffyness!!!

  • September 14, 2010

    by marta

    The wrong images were showing up. The correct ones are posted now and the eye cream is Osmotics Renovage. This is going to be updated to a Five Best, posting tomorrow.

  • September 13, 2010

    by Jaysie

    Marta - Which one of these teprenone products is an eye treatment? I'm confused by the shampoo icons that show up with this article.

  • June 1, 2010

    by anna j

    I use Red Alert serum from Medik8. It feels amazing and helps with redness but also has anti-ageing properties. According to their website, it contains 3% Teprenone in the exact same formula as the trials for the patents and nobel prize. I was so excited i called the company and they were very happy to confirm that they have worked very closely with the original clinical investigators and were most impressed with the anti-redness benefits. they described the same DNA protection and anti-aging effects but said that was not their main focus for this product even though it has very good evidense for efficacy when made according to the trials. Incredible - a company with an anti-aging product that they don't talk about - pinch me!! love the site martha

  • October 15, 2009

    by JulieK

    I use Skinn Wrinkle Balm for "combination" skin (not the dry-normal cited above)- and the difference is amazing. My wrinkle balm is a medium consistency cream that I lather on after all other potions in my nighttime routine to hold in everything during the night. It is not greasy, has a wonderful aroma and, yes, I'm hooked.

    Please note: Wrinkle balm isn't an eye treatment, rather an all over facial potion.

    Peace... ~jk

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