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regenica advanced rejuvenation overnight repair

I am always interested in new stem cell human growth factor serums and was intrigued to try out Regenica Replenishing Crème ($175) with human conditioned media. Especially since Regenica was developed by one of the original team members behind SkinMedica TNS (Tissue Nutrient System), which arguably pioneered the use of human growth factors in skincare.

I was given a bottle of Regenica Replenishing Crème, and I used it as my night cream for six weeks. In the mornings, my skin looked refreshed and felt softer. I believe that there was a positive impact on wrinkles but no visible firming. Overall, I would recommend Regenica, with a couple of reservations.

Human Fibroblast Serum Free Conditioned Media is the most dominant active here. These growth factors (or cytokines) are naturally occurring proteins that stimulate cells to go forth and multiply and differentiate themselves from other cells. Growth factors bind to specific receptors on the cell surfaces. 

Regenica has added in some other actives. There is laminaria, a brown seaweed that retains water in its plant tissues. In cosmetics, it is used to form a moisturizer barrier on the skin. One thing I noticed about Regenica Replenishing Crème is that it did leave my skin looking polished. This is due to a couple of exfoliants. Galactoarabinan is a non-irritating exfoliator derived from larch and there is retinyl palmitate, a more controversial ingredient that the FDA has warned can become toxic when exposed to sunlight (in this instance it is OK since I was using Overnight Repair solely as a night cream). Plus there’s salicylic acid, a beta hydroxyl acid.

I’m not that big on exfoliation and would not use a cream or serum with three potent exfoliators every night. I did use Regenica nightly during my trial period, but typically this is the type of product that I would confine to using a couple of times a week.

The only other standout (though the sodium hyaluronate and vitamin C are perfectly respectable) is ceramide 3. Ceramides are natural components of human skin. There are different ceramide types (conveniently numbered – i.e. ceramide 3) and they play an important role by creating a barrier which reduces infection and helps to retain the skin’s moisture.

In a formula that is mostly benign, the only bad guys include drying alcohol, synthetic emollients and the potential neurotoxin, phenoxyethanol.

  • July 18, 2016

    by Marta

    Hi Laura, I had an allergic reaction to TNS. You can read my review here: https://www.truthinaging.com/review/skinmedica-tns-essential-serum-2013-12-02

    Overall, I think Regenica and TNS are much of a muchness. Bottom line, OK but not standouts. I still think other brands with growth factors, AQ and E'shee, are better.

  • July 17, 2016

    by Laura

    Marta, which do you think is better: TNS Essential Serum or this Regenica one?

  • March 8, 2016

    by Steve

    I suspect Mary Ann has not used Regenica and is trolling. I love The entire Regenica line and recommend it to every patient I come in contact with. There is peer reviewed, published data in Medical Journals that show tremendous efficacy. I saw one publication that demonstrated 100% of patients noticed that their skin was brighter after just two weeks. I noticed results after just 3 days!

  • September 15, 2015

    by Marta

    Hi Mary, conditioned media is sometimes supplemented with animal serum. Regenica is saying it's conditioned media is serum-free.

  • September 14, 2015

    by Mary Lanser

    What is human fibroblast serum free?

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