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Reviewed and recommended: CellularSkin RX Relax Plus Vialox

Is a Solution for:
Sagging Skin
May 27, 2009 Reviewed by admin 5 Comments
Relax Plus Vialox.... a much better option for treating wrinkles than South American poisoned blow darts!

Earlier this year I recommended the C+ Firming Serum and The SuperMax Multi-Peptide skin solution from CellularSkin Rx, and although the SuperMax Multi-peptide didn't work as well for Marta, I was so impressed with the CellularSkin RX products I tried that I decided to look into another one.....Relax Plus Vialox. For the past six weeks I have using the topical wrinkle-reducer and it is worth talking about for a number of reasons.

Let me quickly tell you Relax Plus Vialox ($42) is working quite well for me, but let's first start with "how" Relax Plus Vialox works.

According to the manufacturer of the product's active ingredient pentapeptide-3 (pentapeptide-3 is made by Pentapharm, a 50-year old Swiss company) "Vialox contains a curare-like active pentapeptide-3. This peptide acts in a manner similar to that of tubocurarin, (the) main active compound of curare. As with curare, VIALOX acts at the post-synaptic membrane. The peptide is a competitive antagonist at the acetylcholine (ACh) membrane receptor. As the acetylcholine receptors (AChR) are blocked, the ion channel remains closed. Sodium ions (Na+) are not released and the muscles stay relaxed."

For those of us who skipped science class the day they covered cucare and "competitive antagonists", here is the translation: The topical liquid contains a substance (pentapeptide-3) which is SIMILIAR to curare in the way it works. Curare (ku-ra-ree) is what gives South American poisoned blow darts the ability to paralyze its' target.  With Vialox, the topical application of pentapeptide-3 results in a temporary reduction of the muscle contractions, which is the root cause of facial "expression" wrinkles.  Vialox causes even some of the deeper facial wrinkles (forehead, mouth, laugh lines) to relax within minutes*, and to stay fairly relaxed all day. Think of this peptide as a kissing cousin to Botox, but without the needle, the trip to the doctor, and the frozen expressionless look. You can still smile, raise your eyebrows quizzically, and pronounce all consonants.  You just reduce deep expression wrinkles slowly and over time.

There are a variety of "topical peptide wrinkle reducer" products on the market, so make sure you understand exactly what you are buying: they don't all work in the same way, and the difference in pricing does not always correlate directly with quality of ingredients. Some contain chemicals which are designed to simply SLOW the muscle contractions, and some products are designed to completely INHIBIT muscle contractions by blocking the transmission at the nerve receptor site.  The Vialox product uses the blocking method.... and falls into the category of a nicotinic acetylcholine receptor antagonist. (Dazzle your friends at the next cocktail party with that little gem.)

Because pentapeptide-3 selectively binds to its particular receptor and causes charged sodium ions to cease being released (that is what causes the "depolarization" or the cessation of the electrical charge between nerve and muscle) it must be applied twice daily for 4-weeks, then daily from then on. If you stop using it, those receptor sites are going to resume sending the electrical charges between the nerves and muscles, and facial expression wrinkles are going to eventually return. But because I am seeing great results and it is easy, safe and inexpensive to use, I can't imagine why I would discontinue using it.

So now back to the results of my test. After six weeks of twice-daily use, Relax Plus Vialox has made a noticeable difference in the depth and length of some of the stubborn lines, especially the single deep line across my forehead. I also applied it around my mouth to address the few remaining vertical lip lines that I am successfully banishing with continued use of another product containing collagen. And while my forehead wrinkles now do relax right after applying it, *it took about 3 weeks of twice-daily use before that started to happen.  Maybe it takes that much time for results to be noticeable, or more likely,  it is possible my slow start was "user error".... you really do have to thoroughly rub it in to get it to work. I simply rubbed it ON for the first few weeks, I didn't really rub it IN.  Once I understood that distinction, I saw and felt a difference. And by the way, this clear liquid can go on under makeup, sunscreen, moisturizer etc, without leaving a trace, and despite containing paraben preservatives, it is unlikely to aggravate even the most sensitive of skin.

Ah, but there is more (and I am not talking Ginsu knifes). I was also impressed with the packaging of Relax Plus Vialox.  Not because it is pretty or shiny or elegant (which it isn't) but because it is innovative and allows users to receive the freshest of products.  The Relax Plus "kit" contains  two tiny vials which must be combined into one, in order for the Vialox to be activated. My teeny tiny vial lasted a full six weeks, even with twice daily use, and I expect that the additional vials which I just purchased will each last nearly 3 months, and stay fresh until I am ready to use them.

Lastly... the customer service I received was outstanding. The CellularSkin Rx web site is having a sale right now so I am stocking up, and when I ordered additional vials via the web site on a late Friday afternoon, I was impressed to find that my purchase arrived on Monday morning. And I promise you that CellularSkin RX did not know my order was connected with a review for TIA.  I also purchased two other small testers of additional products later that week, and they too arrived within 48 hours. No complex "automatic deliver" schemes here....when you need a product you simply order it, and you can expect it to arrive promptly.

In summary, if you have some stubborn wrinkles that aren't responding as well as you would like to your current facial regime, Relax Plus Vialox from CellularSkin Rx is something I can heartily recommend.

Ingredients in addition to Vialox:

Water, Glycerin, Pullulan, Silica Gum, Carrageenan, Phenonip, Paraben preservatives.
  • February 6, 2010

    by marta

    I am getting good results on vertical lip lines with YBF Define ( and Osmotics Lipofill (

  • February 6, 2010

    by Dawn Smith

    I would like to know what the collagen product you use for vertical lip lines is. I really would like to find something that works. Can you tell me exactly what products you use,how you apply them and how often you apply. Thanks, Dawn

  • November 11, 2009

    by Teresa Macdonald

    Hi Kate,
    Thank you, I enjoyed your review. What is the collagen product you mentioned. I have vertical lines above my lip.

  • May 29, 2009

    by Kate

    Hi Karla,

    Glad you liked the review and thanks for taking the time to comment.

    I started using DermaRadiant's anti-wrinkle cream earlier this spring on my verticle lip wrinkles which I HATED, and it really helped. I did a posting on it earlier, so try the TIA "search" box and you can read the details. Also, the niacin-based Nia24 hydrating facial cream I used "off label" on my actual lips prior to the DermaRadiant product early on helped a great deal...there is a posting Nia24 (specifically for lips) also. I am testing two alternate products (stayed tuned)on my greatly reduced lip wrinkles , but no matter what cream I end up using I plan to continue with the CellularSkinRx Relax plus Vialox underneath, because it will also prevent any new wrinkles from forming. It works on any kind of facial expression wrinkles...crows feet, forehead, nasolabial folds..... but just know it is not an overnight miracle. It took years for those expression wrinkles to show up, and it takes a few months for them to really go away. CellularSkinRx is having a sale on their website, so I am stocking up!

  • May 28, 2009

    by Karla

    Kate, Great review! I was curious as to what the other collagen containing product you have been using for the dastardly insidious vertical lip line is? Thank you, Karla

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