When I posted my Five Best selection for anti-aging ingredients to look out for, Kathy - clearly a have your cake and eat it kind of girl - wrote in and asked whether it would be possible to combine all five in one cream. Well, Glotherapeutics has almost pulled it off with its GloPeptide + Defense serum. It has three of our five - L-carnosine, spin trap and Matrixyl 3000 - and a whole host of other things to boot.

I've been using GloPeptide + Defense for the past six weeks and it lives up to its billing. It promises to revive the appearance of stressed, fatigued skin and give a healthy, radiant appearance. I can say that it does just that. And when I saw my esthetician the other week, she said (peering at me under the big light she uses to sniff out imperfections) I looked as if I'd had Botox (by which she meant, lines were much diminished - particularly on my forehead). It is also nice to use, with a creamy texture - it's not one of those sticky gels - and a delicate citrus smell.

I must admit that on the first encounter I was a little dubious. GloPeptide seemed to pack everything in, including the kitchen sink. The other thing that I'm not quite with the program on is the idea that ingredients should be chirally correct. Perhaps because I don't understand it... Something to do with only using the left side of the molecule so that it is more readily absorbed by the skin. But then my skeptical antenna really began to buzz (or whatever it is that antennae do) when I saw that it contains Calmosensine - a peptide that is designed to reduce the effects of "negative feelings" on the skin.

There are some people that might say that I could do with Calmosensine on a permanent intravenous drip. Still, I can't quite buy it - despite the in vivo tests conducted by the manufacturer. For those of you with an open mind, it is supposed to modulate perceptions of heat, touch and irritation. It may also interest some of you to know that is used in a product for controlling premature ejaculation.

Ultimately, I was won over by the rest of the ingredients. In addition to my three favorites (mentioned above), there are plenty of antioxidants in the form of, to name just a few, rooibus (red tea), epigallocatechin gallate (the really effective component in green tea), palmitoyl tripeptide-3 (also goes by the name of Syn-Coll and mimics the skin’s ability to produce collagen), niacinamide (vitamin B) and copper peptide. I always like to find a new botanical and was interested to see crataegus monogyna. This is hawthorne and there are studies showing that it is an antioxidant.

I do have a serious reservation in recommending GloPeptide + Defense and that is the inclusion of sodium benzoate. This is carcinogenic when it encounters vitamin C, has been banned from fizzy drinks in the UK and, according to one scientist, it kills off DNA. But I suppose I'm getting negative again - I'd better reach out for another swig of Calmosensine.

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Aqua (Water), Helianthus Annuus (Sunflower) Seed Oil, Caprylic/Capric Triglyceride, Squalane, Rhodiola Rosea Root Extract, Glucose, Chondrus Crispus (Carrageenan), Polawax, Sodium PCA, Cetearyl Olivate, Sorbitan Olivate, Ribes Nigrum (Black Currant) Seed Oil, L-sodium Hyaluronate, Thermus Thermophilus Ferment, Butylene Glycol, Carbomer, Polysorbate 20, Palmitoyl Oligopeptide, Palmitoyl Tetrapeptide-7, Algae Extract, Palmitoyl Tripeptide-3, Rosa Rubiginosa Seed Oil, Laureth-3, Hydroethylcellulouse, Acetyl Dipeptide-1 Cetyl Ester, Alcohol Denat., Cassia Alata Leaf Extract, Rooibos (Aspalathus Lineasris) Extract, White Peony Extract, Simmondsia Chinensis (Jojoba) Seed Oil, Glycerin, Cocos Nucifera (Coconut) Fruit Juice, Epigallocatechin Gallate, Phyllantus Emblica (Amla) Fruit Extract, L-carnosine, Niacinamide, Spin Trap (Phenyl Butyl Nitrone), Acetyl L-carnitine, Ubiquinone, R-lipoic Acid, Crataegus Monogyna Leaf Extract, Phytic Acid, Adenine, Vitamin B Complex, L-glutathione, Cysteine, Tocotrienols, Copper Peptide, Selenium, Manganese, Superoxide Dismutase, Trehalose, D-ribose, C 18-36 Acid Triglyceride, Xanthan Gum, Citrus Aurantifolia (Lime) Oil, Citrus Paradisi (Grapefruit) Peel Oil, Citrus Nobilis (Mandarin Orange) Peel Oil, D-alpha-tocopherol, Gluconolactone, Sodium Benzoate