I'll get straight to the point: ReLuma Skin Illuminating Anti-aging Serum ($145/0.5oz in the shop) works. In fact, I would go so far as to say this is one of the best anti-aging potions that I have come across. It is about a month since I bought and started to try out ReLuma and it has had a significant impact on overall skin tone, plumpness and diminished wrinkles. And - an important plus for me - no allergic reactions or even the slightest sensitivity.
As we age, the critical proteins for healthy skin start to decline. These proteins and growth factors can be isolated as PDGF, VEGF, FGF, IGF3 and TGF-B. Of these, TGF-B is thought to be the most important because its signals are recognized by the majority of cells. TGF-B expression is also induced during wound healing and studies show that it can increase collagen and fibronectin. Meanwhile, PDGF "increases the rate of cellularity and granulation in tissue formation through increased fibroblast function".
Although PDGF, VEGF, FGF, IGF3 and TGF-B all do their own thing, it is the combination of them that is supposed to get results. For example, in order for TGF-b to stimulate fibroblast cell growth, the presence of PDGF is required. In all, ReLuma has nine different human cytokines in the human fibroblast conditioned media.
So where do they come from? The progenitor cells of the human fibroblast are taken from newborn baby foreskins. These are doubtless from babies whose parents volunteered to have them circumcised and no harm was done (I can't help thinking that there is a nice little sideline for rabbis here). Conditioned media is, in fact, the solution (sugars, amino acids and such) that is put in the petri dish in which the cells are grown. The cells secrete stuff or release it when they die and these proteins are then gathered up and put to use ReLuma.
Back to ReLuma. A couple of tiny caveats: the airless pump is a bit erratic (but then that is all too common) and the serum feels a bit tacky for about 10-15 minutes after application (this seems to wear off and this is not in the slightest one of those shiny/greasy numbers). The two preservatives are potential allergans (the iodopropynyl butylcarbamate was accused of such in a Danish study) and DMDM hydantoin can irritate those of sensitive skin. That would be me, but I am happy to report that I have had absolutely no adverse reactions to ReLuma.
I was so pleased with ReLuma's results for me that I contacted Invitra over the weekend to see if I could spread the love. They responded promptly and generously and I'll shortly be receiving a handful of samples for readers to (honestly) review. Please leave a comment to persuade us that you are deserving and honest.
ReLuma was reviewed again in 2011.
Ingredients in ReLuma Skin Illuminating Anti-Aging Serum
Human Fibroblast Conditioned Media, deionized water, gycerin, sodium PCA, allantoin, panthenol, cellulose gum, DMDM hydantoin, iodopropynyl butylcarbamate.