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Reviewed and rejected: Skinceuticals Phloretin CF

Reviewed by Marta September 7, 2012 9 Comments

Skinceuticals CE Ferulic is one of those cult products that has devotees eulogizing to an extent that makes Claire's ode to Jurlique look restrained. So I was excited to be given a small vial of Skinceutical's latest potion Phloretin CF. Five years in the making, Phloretin CF is supposed to take CE Ferulic to new antioxidant heights.

The difference between the two is that Phloretin CF has no vitamin E (CE Ferulic had 1%) and has reduced the dose of vitamin C from 15% to 10%. It has kept the 0.5% drop of ferulic acid and added in phloretin at 2%. Ferulic acid is a powerful, plant-derived antioxidant that seeks and destroys free radicals and improves the performance of vitamins C and E. I have been experimenting with success with a DIY concoction of ferulic acid and vitamin C cream.

But what is phloretin? It is a flavenoid that is found exclusively in apples. According to the Journal of Biological Chemistry, phloretin is an inhibitor of sugar transport amongst red blood cells. And a study in Chemical Research in Toxicology found that it is extremely efficient at trapping cytotoxic compounds such as methylglyoxal. Other studies have (tentatively) concluded that it can prevent the onset of cardiovascular diseases. A Dutch research team has pronounced it to be an inhibitor of lipid peroxidation.

All of which goes to show that the adage of an apple a day has a pretty strong scientific foundation. Nonetheless, my experience with Skinceuticals Phloretin CF has been disappointing. For the last six weeks I have dabbed a little every day on the creases between my eyes. I thought I'd given it a pretty easy job because these wrinkles are comparitively new and tiny. Six weeks later, not one whit of difference. If anything, I found it extremely drying and dulling.

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What is it: Ferulic acid

Ferulic acid and vitamin C beats age spots

  • March 2, 2016

    by Kim

    Have you thought of using Camu Camu. It is said to have the highest concentration of Vitamin C than any other substance in the world.
    My original formula using L Ascorbic Acid and Hyaluronic acid had my skin looking like I was in my early 40's, I'm nearly 57 (from Perth, Australia and never used sunblock). At last I looked as young if not younger than most of my friends even though I am much older than them.
    I'm going to experiment with using my Camu formula on one side of my face and my L Ascorbic Acid formula on the other side and see what happens.

  • October 21, 2015

    by Laurie

    This product has been of benefit to a very specific skin problem for me. Got a good peel from talented esthetician. It did it's job. Unfortunately, my husband didn't understand what was "left" when he came back from a trip- told me I had "something under my eye" and proceeded to rip a small piece of peeling skin...Oh. My.

    Left me with a problem. In my 50s, it was slow to heal. Nothing worked, and I truly though I was headed for a cosmetic surgeon- very noticeable. One drop of Phloretin CF, twice a day, directly on the area, though, caused it to scab/slough/scab until it was gone. After that, the product has "lifted" the dark pigmentation.

    Other than that? Eh, it really hasn't done much for the rest of my skin.

  • May 29, 2014

    by Mary

    Be careful with this product. It took me a while to figure out that every time I put some of this on my face, it became itchy and swollen. I do not have any other allergies. Will not use!

  • July 9, 2012

    by M Mellado

    If you truly want a transformation, the Obagi Nu-Derm System provides just that, with results in 6 weeks or less, it totally transforms your skin down to the cellular level, something SkinCeuticals does NOT do.

  • March 21, 2011

    by Eva

    This product has an enormous amount of denaturated alcohol, which can cause free-radical damage (and this product is supposed to prevent free-radical damage), also, blocks the antioxidant benefits of phloretin, so, it's like nothing, you're not going to have anything from phloretin with this serum, and obviously, this is the reason of why you have found this stuff drying and dulling.
    I wouldn't recommend it to anyone, until SkinCeuticals do sommething with this. It's so disappointing, without the alcohol, would be an amazing serum...

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