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RHAMM - an alternative to Botox and fillers

Is a Solution for:
Sagging Skin
July 17, 2009 Reviewed by Marta 4 Comments
Earlier this year, there was finally a glimmer of hope for those of us who don't want costly and short-lived fillers or, perish the thought, Botox, which can migrate to the brain as well as making you so devoid of expression to look brain dead. Salvation for those with sagging jowls, hollow cheeks and disappearing lips could be arriving in the form of RHAMM.

This stands for Receptor for Hyaluronan Mediated Motility. Mina Bissell, a cell biologist with Berkeley Lab’s Life Sciences Division and a leading authority on breast cancer, and Eva Turley, an oncology professor at the University of Western Ontario, have been studying the role that RHAMM plays in regulating the signaling of adipocytes (fat cells) during the repairing of tissue wounds from injuries such as skin cuts, heart attacks and stroke. Bissell and Turley, working with mice, discovered that blocking the expression of the RHAMM protein - either by deleting its gene, or through the introduction of a blocking reagent - can be used to selectively induce the generation of fat cells to replace those lost in the aging process. At the same time blocking RHAMM expression also reduces deposits of unhealthy visceral fat.

They believe that this will be non-surgical approach for normalizing skin appearance after reconstructive surgery, for wrinkle reduction, and for face lifts and figure enhancement. And they say the effects will be long-lasting - although this hasn't been specified.

There are compounds on the market now that promote the production of adipocyte cells and result in increased subcutaneous fat. However, they also increase the production of visceral fat. The mouse studies led by Bissell and Turley have shown that blocking RHAMM expression significantly increases subcutaneous fat while decreasing visceral fat. This suggests that blocking RHAMM should also have a beneficial effect on patients with obesity-related diseases, cardiovascular disease or diabetes. Another unique advantage of RHAMM is that its expression in normal adult human tissues is restricted.

Sounds brilliant, right? But before you get too excited, keep in mind RHAMM for wrinkles is said to be about three to six years away.
  • July 26, 2010

    by Anh Smalling

    Cosmetic surgery together with non-surgical treatments are very well-know nowadays. Everybody seems to enjoy the "secret of eternal youth" but they miss an important point. Very often people tend to look just at the price and nothing else. It's very important to find out more about the practitioner first, about his/her background and skills not at the deal that is presented otherwise people could end up with a very miserable result.

  • July 22, 2009

    by synergie

    I'd like to propose that they put the money they would otherwise dedicate to ED research to this.

  • July 17, 2009

    by JulieK

    Sounds like a good meditation mantra... RHAMM RHAMM =) ~jk

  • July 17, 2009

    by Kathy

    I am saving my money NOW! Do you suppose they could hurry it up a bit???

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