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Senté Dermal Repair Cream Review

is a Solution for:
Dry Skin
August 28, 2013 Reviewed by Dennis 8 Comments
TRU Rating
An okay moisturizer but no groundbreaking results


Pleasant and subtle scent


Dries before spreading on face

It is easy for me to know when I really like a new product while testing it. First, I start to worry about running out and I will start rationing it. Second I start trying to convince myself that it's worth it to actually purchase, no matter the price. Sadly I have had neither of those feelings with the Senté Dermal Repair Cream ($169.95) I am testing.

Senté is a "science based" beauty line. Their flagship product is their Dermal Repair Cream and their signature ingredient is Glycoproteins. I was happy to see the short list of ingredients on their website when I was first asked to test the Dermal Repair Cream. I had never heard of glycoproteins in skin care so I was very interested. Glycoproteins are proteins that contain a carbohydrate attached to a protein. I have come upon many claims of its legitimacy when they come to skin care:  cellular repair, increased energy level of skin cells by enhancing the production of energy-rich adenosine and increased hydration and elasticity.

Senté claims this ingredient to be a "breakthrough" further saying their glycoproteins "are 'biologically active,' attaching to the surface of cells and allowing growth factors and other molecules to regenerate the skin."

I have been using Senté Dermal Repair Cream for over a month, and though I think it is an okay moisturizer I have not experienced any ground breaking results nor any of the claims listed on their website such as "profound hydration." I understand the need to talk up your product, but come on.

When my package of Senté Dermal Repair Cream arrived the first thing I noticed was that the ingredients on the box did not match those on the website and that really turned me off. However, to be fair the website only lists key ingredients, the top being glycoproteins.

Glycoproteins is not actually spelled out on the box. I wrote Senté asking for clarification and they were kind enough to get right back to me, "Heparan Sulfate (HS), the active ingredient in Senté Dermal Repair Cream, is a Glycoprotein. Many people are not familiar with HS but are familiar with Glycoproteins, so we use that name as an umbrella term. Other examples of Glycoproteins are Hyaluronic acid, Dermatan Sulfate & Chrondroitan Sulfate, all which are not present in our product."

Strange since hyaluronic acid is listed as an ingredient on both the site and the product, but this might just be a matter of confusion.

The cream itself is white and fragrance free, but there is a scent which is very pleasant and dissipates before you even finish rubbing it in. I found the cream does not have a lot of slip and I thought it dried out too quickly, before I could spread it completely over my face. I had to use about five pumps to cover my face and neck. It does leave a nice finish. No greasy feeling or shiny appearance. There is retinyl palmitate so it's recommended to only use at night.

The dispenser itself is very well designed and I had no problems using it.

Perhaps Senté's Dermal Repair Cream needs more time to come into its own. And although I was happy to test and think that Heparan Sulfate is an interesting ingredient and the rest of the ingredients here are fine with no real nasties, the same can be said for a lot of moisturizers at a much lower price point. I do not see myself mourning or repurchasing the Senté it once it's finished, unless after writing this, I see some profound, groundbreaking results.

  • September 4, 2017

    by Michele Eastern

    Sente Dermal Repair Cream has been a miracle moisturizer for me. The person (I think Dennis) that wrote the long negative review obviously works for a competitor. I'm in wholesale furniture and happy to print my first and last name. I am highly allergic to the sun. This product was never sold to me as something for someone with dry skin. It's for all skin types and I have referred many friends with sensitive skin or skin allergies to even food to this product.
    I was first introduced to the product by my doctor. He's the type of man that doesn't carry a bunch of products. In fact he only carries one of the products from Sente and no other product from Sente or a competitor.
    I struggled for years to find a moisturizer that didn't make me break out in tiny dots. Not only does Sente Dermal Repair work as a moisturizer but within fifteen minutes after being out in the sun, my allergic reaction (hives) on my face completely disappeared. I tried ALL of the other specialized products from several different dermatologist and spas. None of them compare. Sente truly diminishes dark spots and small lines. It also improved my skins tolerance to red wine and lessoned the effect of the sun. Yes, I've always worn sunscreen on my face but it's still not foolproof.

    I think the only reason why so many dermatologists don't carry it is because Sente keeps it simple simon by only carrying a few products. Dermatologists and spas like to sell their patients/clients a ridiculous amount of products to make more money. I am 50 years old and find I only need the one product... their dermal repair cream.

  • June 16, 2017

    by Brockiss

    I love Sente dermal repair cream. I also got my husband using it and after a few months could see a huge difference in his skin. It also works like an exfoliator on my skin. I hate being without it but it is very difficult to find these days.

  • November 6, 2016

    by Josie

    At 55, I consulted my aesthetician for products that would reduce wrinkles and improve the tone and texture of my face, and smooth out the area around my eyes and neck. She highly recommended I try Senté: Bio Complete Serum (pm), Dermal Repair Cream (am), and Intensive Eye Therapy (am & pm). I also bought a toner she liked made by another company. I've used all four products religiously everyday for the past 4 weeks. I also exfoliate 2 - 3x's/wk. After approx 4 weeks, my skin's tone and texture improved slightly on my face, and my neck appeared smoother, but I can't discern a noticeable improvement in the reduction of lines and wrinkles on my face or around my eyes. The eye therapy is also supposed to help with puffiness and dark circles, but I haven't yet noticed a difference.
    Side note: the serum feels a little oily, and the dermal cream feels light and dissipates quickly.
    If you incorporate the Bio Complete Serum into your regime, Senté claims that it takes 8 weeks to notice a "significant improvement" in wrinkles, smoothness and texture and after 4 weeks, less than 15% improvement in texture and 5% or less in smoothness and wrinkles, which seems to be accurate based on my observation.
    I will continue to use the Senté products to see if there is a significant improvement by week 8. For what I paid, I hope so.

  • August 29, 2016

    by lesli

    i have to say that I am not a big spender on moisturizers but I really do love this product. Dennis, perhaps your not familiar with hydration before moisturizing. I found 1 or 2 pumps for my face and 1 pump for my neck more than sufficient.

  • June 26, 2016

    by Sharon Stafford

    I have use Sente face and neck products for about a year. It's not an overnight miracle, it took several months before I saw any difference. The amount and depth of facial wrinkles has been greatly reduced. The "crepe" skin around my neck has improved.

  • June 3, 2015

    by cecey

    Wish I had read this review before I bought it. Would have saved me money.

  • August 29, 2013

    by Dennis

    Marta, if I may, here is the full list of ingredients: deionized water, caprylic/capric triglyceride, c12-15 alkyl benzoate, glyceryl stearate, peg-100 stearate, cetearyl alcohol, glycerin, argania spinosa kernal oil, ethylhexyl palmitate, acetyl glucosamine, potassium cetyl phosphate, dimethicone, cyclopentasiloxane, butylene glycol, heparan sulfate, camellia oleifera leaf extract, butyrospermum parkii (shea butter), palmitoyl hydrolyzed wheat protein, tocopheral acetate, retinyl palmitate, sodium hyaluronate, tocopherol, 1,2 hexandiol, caprylyl glycol, acrylates/c10-30 alkyl acrylate crosspolymer

  • August 28, 2013

    by Marta

    Wow, you'd have to be a big believer in glycoproteins. Otherwise this is a very expensive argan oil.

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