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SKIN by Nulastin Rejuvenating Formula

Is a Solution for:
Sagging Skin
Reviewed by Marta April 18, 2011 0 Comments
Nulastin was launched only last year, as both the name of the company and the key ingredient. Somehow it managed to trademark the word skin. Perhaps the US Patent & Trademark Office conceded on the grounds that Nulastin’s SKIN is all upper case. I think I might try to trademark leg or toe or TOE, just to see if I can. Anyway, I digress. What you really want to know is what Nulastin (also trademarked) might be.

SKIN by Nulastin claims that Nulastin, aka SH-polypeptide 50, is the precurser to human elastin. Elsewhere, I discovered that SH-polypeptide 50 was discovered in the mid 1980s and the SH stands for small hydrophobic. Beyond that, there is surprisingly little information on SH-polypeptide 50. Outside of planet Nulastin (where the only study was conducted internally on 28 people), I couldn’t find any information on SH-polypeptide 50 and elastin or tropoelastin (the precurser). I did come across a variation, SH-polypeptide-9, used by Jan Marini in her Transformation Face Cream.

Although the Nulastin secret sauce remains an unconvincing enigma, the overall formula for SKIN by Nulastin Reuvenating Formula ($89) looks fairly interesting. Some, however, will be put off by the nature of some of the non-active ingredients. First the good. Hydrating sodium hyaluronate is featured near the top of the ingredients list, along with palmitoyl pentapeptide-4 (the collagen boosting peptide that is known as Matrixyl) and the expression line inhibitor acetyl-hexapeptide-3.

I was interested to see L-selenomethionine. With this ingredient, you will be please to know that there has been at least one independent study showing that topical selenium can reduce sun damage and hyperpigmentation. By using it along with the amino acids L-proline and L-cysteine, Nulastin gets to call it ProliSel (a name that it has, of course, registered).

Things not like include propylene glycol, as this potential irritant is the third most dominant ingredient. Also irritants are the toxicant triethanolamine, the controversial tetrasodium EDTA, iodopropynyl butylcarbomate, and DMDM hydantoin. There are also a couple of parabens. Perhaps Nulastin’s trademark attorney should go after SKIN breakout.


Water (Aqua), Carthamus Tinctorius (Safflower) Seed Oil, Propylene Glycol, Isopropyl Palmitate, Sodium Hyaluronate, Glycerine (AND) Palmitoyl pentapeptide-4, Acetyl-Hexapeptide-3, Glyceryl Stearate, PEG-100 Stearate, Tocopheryl acetate (Vitamin E), Ceteareth-20, Cetearyl Alcohol, Stearic Acid, SH-Polypeptide 50 (NulastinTM), L-Selenomethionine and L-Proline and L-Cysteine (ProliSelR), Provitamin B5, Myristyl Myristate, Carbomer, Triethanolamine, Dimethicone, Methylparaben, Propylparaben, DMDM Hydantoin, Iodopropynyl Butylcarbamate, Tetrasodium EDTA, Fragrance

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