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SKIN by Nulastin Rejuvenating Formula

Is a Solution for:
Sagging Skin
April 18, 2011 Reviewed by Marta 2 Comments

Nulastin was launched only last year, as both the name of the company and the key ingredient. Somehow it managed to trademark the word skin. Perhaps the US Patent & Trademark Office conceded on the grounds that Nulastin’s SKIN is all upper case. I think I might try to trademark leg or toe or TOE, just to see if I can. Anyway, I digress. What you really want to know is what Nulastin (also trademarked) might be.

SKIN by Nulastin claims that Nulastin, aka SH-polypeptide 50, is the precurser to human elastin. Elsewhere, I discovered that SH-polypeptide 50 was discovered in the mid 1980s and the SH stands for small hydrophobic. Beyond that, there is surprisingly little information on SH-polypeptide 50. Outside of planet Nulastin (where the only study was conducted internally on 28 people), I couldn’t find any information on SH-polypeptide 50 and elastin or tropoelastin (the precurser). I did come across a variation, SH-polypeptide-9, used by Jan Marini in her Transformation Face Cream.

Although the Nulastin secret sauce remains an unconvincing enigma, the overall formula for SKIN by Nulastin Reuvenating Formula ($89) looks fairly interesting. Some, however, will be put off by the nature of some of the non-active ingredients. First the good. Hydrating sodium hyaluronate is featured near the top of the ingredients list, along with palmitoyl pentapeptide-4 (the collagen boosting peptide that is known as Matrixyl) and the expression line inhibitor acetyl-hexapeptide-3.

I was interested to see L-selenomethionine. With this ingredient, you will be please to know that there has been at least one independent study showing that topical selenium can reduce sun damage and hyperpigmentation. By using it along with the amino acids L-proline and L-cysteine, Nulastin gets to call it ProliSel (a name that it has, of course, registered).

Things not like include propylene glycol, as this potential irritant is the third most dominant ingredient. Also irritants are the toxicant triethanolamine, the controversial tetrasodium EDTA, iodopropynyl butylcarbomate, and DMDM hydantoin. There are also a couple of parabens. Perhaps Nulastin’s trademark attorney should go after SKIN breakout.

Editor's note: the ingredients here as of the time this review was written. As of 2017 the formula has been revised.

  • June 3, 2017

    by Ian Adamson

    There is nothing enigmatic about Tropoelastin, the bioactive ingredient.

    As a biomedical engineer and sports medicine professional (masters degree), I was intrigued by the clinical efficacy of this product. Systematic review of the science shows that this is solid, so I tested the skin product when it was first launched.

    Initial indications showed measurable improvements in skin tone, plumpness and elasticity, so I have continued using it to this day. The net result is more profound positive changes and arrest of signed of aging.

  • June 3, 2017

    by Leah

    Always a grand step forward when a formulation evolves to meet consumer demands for naturally derived, Paraben-free, cruelty-free ingredients. Likewise, to truly understand a company's mission and focus is to unveil its intention; ethics and a commitment to providing a beneficial user experience with experientially positive results. NULASTIN®, Inc. 2017, is a women run, women-focused company that has proudly partnered with Dr. Burt Ensley, a pioneer in the field of microbiology. Dr. Ensley's methodology for creating Elastatropin®, aka Tropoelastin®, aka .SH-polypeptide 50 is truly unique. His biomaterial is the only known source used in cosmetics to receive funding from the National Science Foundation. Also noteworthy, is that many sources of elastin-replenishment used in cosmetics are animal derived (boiled tendons and ligaments) and/or plant based, questionably effective as a means to deliver elastin to the matrix of the skin. NULASTIN offers a lifetime performance guarantee, which speaks volumes about the efficacy of the products and makes it an easy, no-risk solution to more youthful, supple, fabulous looking skin.

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