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The Best Skin Care Regimen for Your 50s

Closeup of middle-aged woman
January 30, 2018 Reviewed by Marta 11 Comments

The big 5-OH. This is a decade of hormonal ups and downs. Menopause — peri- and the real deal — affects nearly every woman in her 50s. As a result, you will experience a steady decline in estrogen, which causes a fast and furious decline in collagen production — and with it your skin’s bounce, moisture and glow may seem to disappear overnight. Now is the time to fight back. Hormone therapy, where estrogen levels are raised just high enough to alleviate symptoms, is a safe option for many women. At home, focus on strengthening the skin’s moisture barrier, encouraging collagen production and working to thicken the skin. Arm yourself with the ultimate 50-something regimen.

Cleanse and exfoliate

Ditch harsh soaps, lower the temperature of the water and wash your face only at night in order to preserve the already-low levels of moisture in your skin. Choose a low- or no-foam cleanser that will replenish the skin with essential nutrients as it rinses away makeup, dirt and airborne toxins. Look for hydrating ingredients, antioxidants and anti-inflammatory agents.

Skin 2 Skin White Tea Face Wash ($37 in the shop) uses mild cleansing agents that are naturally-derived and is pH balanced to protect the delicate balance of the skin’s acid mantle. It also contains antioxidants like white and green tea, phytonutrients and moisturizing glycerin. You may also like Ao Skincare Prepare Cleanser ($39.95 in the shop). This milky wash is packed with antioxidants, like totarol and ferulic acid, as well as essential omega fatty acids to strengthen the skin barrier.

Once you’ve gotten comfy with a cleanser, get in the habit of weekly exfoliation. This helps create a canvas that lets anti-aging treatments penetrate more effectively. Your starting point may be daily sloughing with a cleansing brush that removes debris and dead cells to keep the skin clear. (Both aforementioned cleansers are compatible with cleansing brushes.)

Or, if your skin can tolerate it, consider twice a week exfoliation with alpha hydroxy acids, such as glycolic or mandelic acid, to promote cell turnover. Try Dr. Dennis Gross Original Alpha Beta Peel ($88 in the shop), which uses a blend of AHAs and BHAs.

Anti-Aging Serum

This is going to be the heavy artillary in your regimen. You can focus on wrinkles or sagging, depending on your major concern - or both. KERACELL Anti-Aging Facial Serum ($100 in the shop) has growth factors for building collagen. Skin 2 Skin's Anti-Sagging Renewal Serum ($73 in the shop) does what it says on the tin with peptides and botanicals.


Perhaps the most important step in your regimen is moisturizing. Because dry skin exacerbates the look of fine lines, wrinkles and uneven texture, you’ll want to load up. Moisturizer replenishes the lipids on the surface of the skin that are weakened in your fifties due to estrogen loss. Find a consistency you are comfortable with — whether it be a rich cream, lightweight lotion or hydrating serum — and a formula that has barrier-bolstering lipids, omega fatty acids and polyphenols.

These days well-formulated creams multitask with added anti-aging benefits, so you may also want to scan ingredient lists for plumping peptides, collagen-boosting vitamin C, anti-inflammatory niacinamide and radiance-enhancing enzymes. Dr. Dennis Gross has a new moisturizer called C+ Collagen Deep Cream ($72 in the shop) that is designed to revive the complexion as well as hydrate. For a lighter hit of hydration, try Your Best Face Hydrate B Concentrate ($45 in the shop).

Get in a retinol routine

Retinol is a derivative of vitamin A that is commonly known for slowing the signs of aging skin. Other forms include retinal, retinoic acid and retinyl ester. Years of research shows this group promotes cell regeneration and can stimulate the production of new collagen, thus decreasing wrinkle depth, smoothing the surface of skin and the lessening the look of dark spots.

If you are new to retinol, start slowly. Try Ao Skincare Rewind Retinal ($119.95 in the shop); it uses retinal, which is less likely to cause skin irritation and flaking, and supports it with antioxidants like bakuchiol and astaxanthin. Apply it every other night, gradually increasing use over time. For a stronger dose, try Sciote Advanced Retinol Crème ($64 in the shop) with a potent 2 percent retinol that is buffered in a soothing aloe base.

Because retinoids can make skin more sensitive to the sun, always apply at night and don’t forget that daily use of sunscreen is a must.


To finetune your regimen, consider taking these extra steps.

Remodel the mouth area

Dermatologists agree, the mouth tends to be the area that bothers women in their 50s most. Sagging skin around the mouth and chin, the folds (or marionette lines) that accompany sag and lip lines are all cause for concern. Treat lax skin to plumping peptides like Matrixyl 3000 and caprooyl tetrapeptide-3. Try Sciote Peptide + Defense Firming Youth Serum ($105 in the shop). To soften vertical lip lines, go for Your Best Face Define (70 in the shop), which uses a peptide complex called Hilurlip.

Give your eyes a lift

Do your eyes appear tired and sunken? Consider an eye cream with retinol, like Dr. Dennis Gross Skincare Ferulic & Retinol Eye Cream ($68 in the shop). By building collagen, these creams help to minimize the appearance of dark circles that are in-part caused by blood vessels close to the surface of thinner skin while also reducing lines and wrinkles. For an all-round multitasking Your Best Face Correct ($150 in the shop) is the be all-end of eye creams.

Pay attention to your neck

The neck has a major gravitational disadvantage. Pay attention to it now to prevent sagging and creases later on. We like fast-absorbing ClarityRx Keep Your Chin Up Age-Defying Neck Serum ($69.50 in the shop). We also recommend using the red LED light and ultrasonic waves settings on the Truth Vitality Lux Renew ($279 in the shop) along the jawline and neck to tighten skin. 

  • January 11, 2019

    by Tamie

    I am at loss on what I should get I keep buying different stuff and not working tired of spending on stuff that doesn't work do you have travel samples

  • December 9, 2018

    by Marta

    Hi Tracy, you can use these either morning,night or both - whatever works best for you. Anything with retinol - such as the DDG Ferulic and Retinol - should be used in the evenings only.

  • December 9, 2018

    by Tracy

    This is wonderful! But is this a before bed routine or both morning and night? And if both is there anything I should only apply at night versus the morning? Thanks!

  • November 26, 2018

    by Marta

    Hi Margaret, the shop is on this website. In the nav bar at the top of the page there is a big green tab that says "shop". And it will take you to the shop main page - this is the URL: Every product recommendation is linked to their shop page where they can be purchased - just click on the product names in this article.

  • November 24, 2018

    by Margaret

    You keep saying the item you cecomend are available "the shop"what shop. ??

  • February 1, 2018

    by Marta

    Hi Becky, the glycolic is not a major feature of the DDG Deep Cream and so I don't think using it after a retinol would be overkill.

  • January 31, 2018

    by Becky

    Thanks Marta! just noticed the Dennis Gross moisturizer mentioned here has glycolic. Does your recommendation to apply retinol and then follow with this particular moisturizer still hold? thanks!

  • January 31, 2018

    by Marta

    Hi Becky, retinol goes first and then wait 10 minutes and then serum followed by moisturizer

  • January 31, 2018

    by Becky

    Marta - what order for the serum -retinol - moisturizer?

  • November 11, 2017

    by Marta

    Hi Robin
    Not even that - unless needed. Depends on how your skin looks and feels after waking up. Sometimes mine needs a splash, other times I feel I need a dab of toner, sometimes nothing. The bi-weekly reference has now been edited to say twice a week.

  • November 11, 2017

    by robin makki

    Thank you for this post, very helpful guide. I have a few questions though:
    - "wash your face only at night" ... is the suggestion to only rinse with water in the AM? or not even that? please explain more.
    - "bi-weekly" can be confusing (at least to me : ) ... do you mean 2x/week or every other week??
    Thanks for your input.

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