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The Best Line of Defense for Different Wrinkles

Senior female face with wrinkles
August 30, 2016 Reviewed by Marta 5 Comments

Know your enemy is a sensible motto in the age old fight against lines. When it comes to wrinkles, I believe that the more I know about them, the more likely I am to do more than just put my hope in a jar. A few weeks ago, I asked myself a very basic question, what is a wrinkle? The answer turned out to be more complex than I would have guessed. To understand the various treatments, you must first understand that there are different types of creases — some dynamic and some more stubborn. Learn the best line of defense whether yours appear only when you smile or they seem permanently etched in your face.

Crow’s feet

I am starting with the lines that dart from the outer corners of the eyes as these are, for most of us, the first that we encounter. They are also called laugh lines since they are caused by repeated facial expressions like smiling or squinting.

There is a class of peptides that target expression lines, known as neuropeptides, although they work by different mechanisms. For example, Argireline works by blocking the release of acetylcholine. Whereas Syn-ake doesn’t block acetylcholine from its release, but from its uptake by the receptors. Syn-ake is deemed to be much more effective at reducing the frequency of muscle contractions.

ClarityRX Get Fit Serum ($105.75 in the shop) has four of these peptides: Argireline, Syn-ake, pentapeptide-18 and SNAP-8. It is working wonders on my crow’s feet. You will also find Argireline in Brad’s Ultra Elastin Lift ($210 in the shop), which also contains Syn-ake. There are three expression line-reducing peptides in Benir Beauty Platinum serum ($195 in the shop).

Eleven lines

Those parallel vertical lines between the eyebrows are also formed from expressions like squinting and frowning, and in the early stages, the peptides mentioned above can be helpful. But when these wrinkles become deep and stubborn, some different approaches are needed.

Subjects in our clinical trials saw good results from the Truth Vitality Lux Renew ($279 in the shop) and there’s a particularly good before and after picture on the eleven lines of one of them.

Deep lines also benefit significantly from growth factors that signal to cells to repair skin. An always reliable choice is AQ Skin Solutions Active Serum ($149 in the shop) with a proprietary complex of human conditioned media.

Fine and crepey lines

We really want to be thinking about skin resurfacing when it comes to fine lines and crepey skin. One of the best approaches is the high-powered exfoliating action of hydroxy acids.

There are 15 of them in Dr. Dennis Gross Skincare Alpha Beta Medi–Spa Peel ($110 in the shop). This is the closest thing to having the iconic peel in the doctor’s New York office. Although your skin doesn’t actually peel with the treatment, dead cells are being efficiently removed to encourage new collagen production as well as creating a pore-tightened and more radiant complexion.

Lip lines

The newly reformulated Your Best Face Define ($70 in the shop) has six peptides to combat lip lines and give the mouth a fuller, more contoured appearance.  Matrixyl Synthe-6, Syn-Hycan, coenzyme Q10, and glycyrrhetinic acid from licorice root and there’s even a complex called Preventhalia for UV protection because, well, who puts sunscreen on their pout.

Forehead lines

There’s nothing scientific about this recommendation, just a personal success story with horizontal forehead lines. I’ve found that a combination of ClarityRX Get Fit and MitoQ has made such a difference that I almost can’t feel my lines when I run my finger over my forehead. I can look at myself in public restroom mirrors under horrid florescent lighting. Now that’s a test.

Marionette lines

Just about the best thing I have found for marionette lines is ultrasound. You can see some of the results in these  before/after pictures of subjects in our clinical trials for the Truth Vitality Lux Renew ($279 in the shop).

Neck lines

Neck lines, or tree rings, are another challenge. Loss of elasticity is a key issue. The skin of the neck has less sebum than the face, so moisturizing is really important.

Deciem NIOD Neck Elasticity Catalyst ($70 in the shop). The NIOD formulas are always interesting and this one is no exception. Hydrating hyaluronic acid plays a critical role and there are plant extracts and peptides that boost the skin’s elastin. 


  • March 23, 2018

    by J

    I think Peggy, Angela and the rest of us who don't want to spend over $100 on a product should get some recommendations before we start thinking that it's all about profit.

  • January 12, 2018

    by Peggy

    Hello. I’ve gone through quite a bit of your recommendations for the over 55 crowd. I’m retired military and could never afford to keep up with all the different suggestions. Aren’t these companies making “anti-aging” products realize many women are retired and on fixed incomes? Are there any quality products out there cheaper? I may not make a lot of money but I want to fight these wrinkles and sagging just as much as anyone else! God Bless. Peggy

  • August 31, 2016

    by Marta

    Hi Debra, I think they are different. Medik8 is more for firming and Get Fit is for expression lines.

    Hi Angela, you could take a look at ASDM's Matrixyl 3000 serum at $35

  • August 30, 2016

    by Debra

    How does Medic8 Firewall compare to some of the new serums, such as, ClarityRX Get Fit? Specifically, on forehead lines? I am currently using it and have in the past. I've also used MitoQ and like it as well.

    Also, is there one serum and/or moisturizer that works for all lines & wrinkles! Lol!

    As always, thanks so much!

  • August 30, 2016

    by angela

    i noticed that all your cream treatments suggestions are all very expensive.
    I am 60 years old with normal/dry skin and a few wrinkles on the 11 and down the nose.
    what will be your alternatives for these issues.

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