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The Five Best with Sodium Hyaluronate

Solution for:

Dry Skin, Fine Lines, Wrinkles
April 18, 2016 Reviewed by Marta 1 Comment

Sodium hyaluronate — the sodium salt of hyaluronic acid — became something of an “it” ingredient when The Archives of Dermatology pronounced it one of three anti-aging treatments available that are proven clinically effective. In our bodies, it is found within the extra-cellular space within tissues, especially those of the face. Its water-binding and water-attracting attributes fill up the spaces between the connective fibers collagen and elastin in the dermis. Like most things, it decreases with age and, therefore, we need to top it up.

As soon as that endorsement from The Archives of Dermatology came out, it seemed as if everything suddenly boasted sodium hyaluronate. It is now so ubiquitous, that it is tempting to say blah. But not so fast, there are new versions with different molecular weights, plant-derived alternatives and formulations that help penetration. Here at Truth In Aging we try to keep in step with technology and are excited to bring the latest and greatest, indeed the Five Best with sodium hyaluronate.

  • Deciem NIOD Multi-Molecular Hyaluronic Complex

    Deciem NIOD Multi-Molecular Hyaluronic Complex ($38 in the shop). NIOD is such an interesting line and it doesn’t do anything by halves. This serum has, can you believe, no less than12 different hyaluronic compounds. They are a mix of high, mid and low molecular weight compounds, as well as plant-based and a fermented high molecular weight hyaluronic acid. And if that wasn’t enough, there’s a peptide-charged delivery system. Talk about punching above its price point.

  • Sciote Super Moist Hyaluronic Serum

    Sciote Super Moist Hyaluronic Serum ($75 in the shop). Here the active is Hyalurosmooth, a plant-derived alternative to sodium hyaluronate. Sciote claims a 50% concentration. This is so hydrating that our reviewer said, memorably, that she went from raisin to grape. There are all sorts of other good things here, but worth a specific call out are wild-crafted green tea and Sciote’s signature MSM, a form of sulfur that has the ability to enhance collagen bundles and keratin, the important stuff in our skin, hair and nails.

  • Your Best Face Hydrate B Concentrate

    Your Best Face Hydrate B Concentrate ($45 in the shop). This is now a classic, a deceptively simple formula that is effective and at a decent price. Not content with sodium hyaluronate, YBF added Syn-Hycan. This is actually meant to stimulate hyaluronan (our natural hyaluronic acid) synthesis and expression of the proteoglycans, decorin and lumican. So this is firming as well as hydrating. There are also three forms of vitamin B. This serum was a Five Best back in 2014 and deservedly on this year’s list.

  • Stemulation Hi-Impact Serum

    Stemulation Hi-Impact Serum ($185 in the shop). Dewy is all I can say. This is one of my favorite all-round serums as, over time, the condition of my skin becomes velvety. leaving it feeling and looking soft and silky smooth. This serious serum uses a trifecta of sH-Oligopeptide-1 (an epidermal growth factor), hyaluronic acid and Madonna lily leaf (this botanical extract may help with hyperpigmentation). The water retaining capability of the hyaluronic acid is given a boost with pseudoalteromonas exopolysaccharides, which does more of the same.

  • Dr. Dennis Gross Hyaluronic Moisture Cushion Oil-Free Moisturizer

    Dr. Dennis Gross Hyaluronic Moisture Cushion Oil-Free Moisturizer ($58 in the shop). This cream lives up to its name with a cushiony bounce that meets the first dip of the finger in the pot. The moisturizer’s unusual consistency seems to be enveloping and soothing the skin. The sodium hyaluronate is ably backed up by phospholipids, another ingredient that draws in and retains moisture. I like watermelon extract, which contains antioxidant lycopenes, cinnamon bark, which has been shown by studies to improve lipid function (lipids are the building blocks of cells). Several skin brighteners make this a good all-rounder.

  • September 11, 2016

    by aa

    Some of the info presented here is misleading. High molecular weight HA does not go through the outer layer of the skin (epidermis) so having it in creams does not help at all, as it is not absorbed by the skin, much like collagen molecules, so heavily advertised as ingredient of creams. High molecular weight HA can only work when injected directly in the derma as in fillers like Juvederm, or when spontaneously produced there by our cells. And low molecular weight HA can be inflammatory. An HA around 50kDa is ideal in a topic creams but nobody indicates the size of HA in their products and only few the percentage of the total weight. HA is a polymer of two disaccharides and this unit can be repeated many times creating HA of different sizes so having 12 of them is not so difficult and impressive. All you need to do is used polymers made of different number of units.

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