Cosmedicine Megadose Skin Fortifying Serum is the kind of product that really annoys me; it is such a cynical con (probably to be expected given the faux pharma packaging and branding: usually a dead giveaway).
Now I should point out that Truth In Aging does not accept free products to review. The mission to be a skeptical curmudgeon cannot be compromised. However, sometimes the products I buy come with little trial sachets, which is how I came by Cosmedicine's Megadose serum. I want it on record that I would never pay $80 for what is little more than a mixture of silicones.
What gets me about Cosmedicine is that it actually proudly proclaims that the "active ingredient" in Megadose Skin Fortifying Serum is dimethicone. This is a silicone commonly used in hair and skin products. It sits on the surface to create a silky, velvety feeling. Perfectly nice, but completely pointless. Silicone is not doing anything to improve the condition of the skin. There is nothing "active" about it.
Curiously, Cosmedicine Megadose serum also contains the two peptides that make up matrixyl 3000 (which does show promise of being a very good anti-oxidant). However, since the dimethicone amount is stated to be 1% and is dwarfed by cyclopentasiloxane (another silicone, commonly found in hairspray), it is probably safe to assume that the quantity of matrixyl 3000 in this product is not a megadose, but a dose so small as to be inconsequential.
On top of all of this, Megadose serum has a nasty gooey texture, a violent orange color and smells like diapers.