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TruActivs TriToxin Review

is a Solution for:
Crow's Feet, Fine Lines, Wrinkles
truactiv tritoxin
November 9, 2015 Reviewed by Marta 7 Comments
TRU Rating
Filled with impressive actives, give this serum time to work its magic


Softens crow's feet and forehead lines



When you buy a TruActivs product, your money certainly isn’t going into the packaging. The company boasts that it has its own privately-owned lab and that they invest in ensuring that their products have a high concentration of actives rather than fancy marketing or components. TruActivs TriToxin ($220), which I have been testing for about six weeks, is plastic, utilitarian and proud of it. So does the focus on ingredients pay off?

The short answer is yes, TriToxin, has done a good job of softening crow’s feet and forehead lines. I decided to focus on these areas since I have been neglecting them of late and really thought I was beginning to see a worsening. TriToxin has certainly reversed this and I have been slowly but surely seen cumulative effects over a month and a half.

The formula takes some novel approaches and with three types of venom — bee, snail and “snake” — is not for the faint hearted. There’s a lot going on in this serum, including growth factors, copper and grape stem cells, but I’ll start by discussing snail venom since that was a new one for me.

I didn’t even know snails had venom. I don’t think the garden variety do, we are talking one genus of snail, cone snails (sea snails), which is worth Googling as it is a flamboyantly patterned creature. It recently got the attention of medical science when it was discovered that it’s venom could be used as a powerful painkiller. Cone snail venom is packed with peptides (as much as 100 different peptides in every snail) and in small amounts these neurotoxins prevent muscle contractions.

Bee venom is better known to me as an anti-aging active. Apitoxin acts as a strong anti-inflammatory and antiseptic. One researcher claimed that apitoxin "deserves no less attention of the medical profession than antibiotics of fungal and bacterial origin." It’s 18 active compounds include peptides and hyaluronidase.

The third venom is Syn-Ake isn’t really a snake venom, but a combination of neuropetides that mimic the peptide in vipers called Waglerin-1 to relax muscles and minimize — at least in theory — expression lines. 

It is worth noting that you shouldn’t feel anything with these actives. There is no stinging sensation from bee venom and there is no hint that the facial muscle movement is even slightly impaired. Nor are there any adverse effects from one of the other bee-related actives, royal jelly. This is secreted by honeybees to feed and nurture queen bees. It contains amino acids, fatty acids, antioxidants, proteins, minerals and vitamins (including B1, B2, B5 and B6). Its high water content in addition to its fatty acid content make it an effective moisturizer. Its silicon content can bolster collagen production, supporting skin renewal and firming skin. Royal jelly also contains high amounts of antioxidants, which help combat free radical damage.

Although TruActivs makes a big deal of the venomous sting in TriToxin’s tail, there is a roster of other heavy hitters here. A very welcome inclusion is sH-oligopeptide-1, an epidermal growth factor. There are two forms of plant stem cells, grape and alpine rose. Pseudoalteromonas ferment extract is a peptide sourced from a bacteria that can boost collagen, according to research. Also worth a call out are zinc and copper gluonate.

This unscented cream is definitely active intense. There are few if any fillers and the usual suspects in the preservative department. With visible results in six weeks, TriToxin is my kind of poison. There is just one consideration, however, and that is that there is a price to be paid for such a star-studded cast. I’d really like to know if others would find TriToxin worth a $220 price tag and so we’ll be putting one up for a “Test with Marta” soon!

  • September 10, 2016

    by Kathleen

    I would like to try this product. I would be so nice to purchase a product that really works as it advertises. Is it worth the $220 price label you ask. I suppose it would depend on how long the bottle/product would last and how many applications would be in the bottle. Those questions haven't been answered. It would also be nice to see before and afters or if nothing else let people free trial the item in a sort of group for effectiveness. Advances are made every day in the world of anti-aging and ones that work are wonderful

  • November 12, 2015

    by Marta Wohrle

    Hey Kate! What a lovely start to my day to see your comment. Welcome back to the TIA community. We'd love to have you review again. If, for some reason, you don't get picked for this one, email and have a chat with Elisa our reviews editor about what's in the queue. I hope all has been well with you.

  • November 12, 2015

    by Mar

    I got Botox earlier this year (June) and surprisingly loved it. ALL of my expression lines were gone (horizontal forehead, bunny lines, "elevens" etc). But now that it's been worn off for a few months, I'd love to try this to see how it compares to the needle. I've had luck in the past with retinoids and peptides, and maintain a vitamin c regimen even though I can't tell a real difference :)

  • November 11, 2015

    by kate

    Hi Marty, Immmmm baaaaack! It has been a few years since I last tested products on behalf of Truth in Aging (byline Kate) and TruActives TriToxin is just what I have been waiting for. I am mid 50's, and while I cherish the well earned laugh lines around my eyes, I am starting to notice the dreaded frown lines, lip lines and now wrinkles between my eyes. all of which are just plain horrifying. Time for me to fight back against Ma Nature but without any nips or tucks!

    Love to try this for a few months, on half of my face complete with before and after pics, and let everyone know if this triple whammy is a "Beauty" or "Beast". Pick me, Pick me!!!!

  • November 11, 2015

    by Janice

    I'd really like to try this along with Marta. I've tried a lot of things over the last couple of years, but haven't really settled on a regimen. I have bangs, so the one area I've really neglected are my forehead lines and some weird creases across the top of my nose. I would love to see whether TriToxin can smooth those out and give me the option of getting my bangs off of my forehead next summer!

  • November 10, 2015

    by Diane

    Hi Martha,

    I'd like a chance to try TruActivs TriToxin. The ingredients sound intriguing to say the least! I'm familiar with bee venom, and have tried several products with that ingredient, as there are several companies in New Zealand that are marketing this ingredient. The products I've tried haven't been too impressive. I haven't seen anything with cone snail venom (who knew?) or snake venom analogues. I'd love to give TriToxin a try, but would be reluctant to spend $220 on a bottle without knowing whether it would produce any noticeable results. I'm at the high (ahemm...) end of middle age, and have started to see more fine lines around my eyes, and more alarmingly a number of fine lines on my lower cheeks. If TriToxin could knock some of these on their heads I'd be thrilled!



  • November 10, 2015

    by Melanie

    I'm by no means a vegetarian but really, these poor creatures are most likely giving up their lives for wrinkles?
    Food - yes
    Medicine- yes
    But beauty products? I'm all for looking my best and can show the receipts to prove it. But when is enough enough on this quest for eternal youth? Age isn't something to be ashamed of but proud of. I'm 47 and I'm not happy with all the changes but really, our age is to be celebrated because it means we've overcome some huge obstacles and we are still here to talk about it!

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