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What is it: Artefill

Is a Solution for:
Sagging Skin
April 19, 2008 Reviewed by Marta 1 Comment
Artefill is a permanent injectable wrinkle filler. Invented by a German plastic surgeon, it has been used for more than 13 years in the UK where it goes by the name of Artecoll. It is reputedly responsible for Liz Hurley's pout.

Artecoll has not been without controversy. There have been numerous cases in the UK and Canada of the product migrating unbidden to areas of the face that were not injected and causing something called granulomatous (nasty bumps and lumps).

It is a pretty simple mixture of 80% bovine collagen and 20% PMMA, polymethylacrylate, or as you and I would more likely recognize it, acrylic or Plexiglas. Its consistency is not unlike toothpaste. The bovine collagen eventually disappears leaving the acrylic, which is more than permanent: just think, it will be still be there long after you are gone. Talk about getting your money's worth. As one doctor and early adopter who has since stopped administering to his patients, Claudio de Lorenzi said, the only way to remove it, is to cut it out.

It was FDA approved for the US a couple of years ago, with some minor changes. Artefill was required to reduce the bead size and make more uniform the PMMA, use only local cattle herds for the collagen and manufacture the product in an approved US facility.

One of the problems with Artecoll/Artefill is that the adverse effects can take years to develop. One woman is reported in a European medical journal as developing granulomatous about 12 years after the injections were carried out.
  • September 13, 2014

    by dee

    technically aretfill is not a 'dermal filler.' it's approved by the fda in america as a 'medical implant' devise. most reports of problems are from the older product never approved for use in america by the fda - articoll. reports of artefill migration are purely anecdotal. no controlled scientific study to date has found that the product migrates, though some doctors maintain they've seen it in their practice. it does require an experienced injector. incorrect injection technique can lead to ineffective aesthetic results/correction and long-term problems. in fact most problems with either can be traced to improper injector technique, which includes using the products in areas of the face it's not well suited for. artefill is only fda approved for use in the nasolabial folds (smile lines) area, though most doctors will use in in other places as well. though some dotors do do it, it should 'never' be used directly under the eyes, or between the eyes (frown lines area). any dermal filler can cause granulomas. however since the pmma spheres are in place for a long time, where as other fillers are absorbed by the body in 4 to 12 months, the chances of granuloma formation down the line increase. i like the results over juvaderm.

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