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What Is It: Sepiwhite

September 25, 2008 Reviewed by Marta 14 Comments

Sepiwhite is being hailed as a breakthrough age spot fader that takes a novel approach to controlling hyperpigmentation. If it works as well as the manufacturer claims then it will be a welcome alternative to hydroquinone (which does work, but at a price - in France it is banned because of links to cancer).

The key thing in the regulation of skin pigmentation is melanotropin, also called alpha-MSH. Melanotropin controls tyrosinase activity, melanin (eumalanin) synthesis and melanosome. Sepiwhite MSH is a molecule that works by "antagonizing" alpha-MSH and inhibiting tyrosinase. Tyrosinase is the essential enzyme in the formation of melanin by converting DOPA to DOPAquinone. Therefore, reducing its activity is a principal method of improving skin tone and the one most commonly claimed for ingredients in current production for skin lightening. However, the manufacturer claims Sepiwhite inhibits all the other stages of pigmentation as well.

In a test conducted by the manufacturer, a 2% solution of Sepiwhite was compared to the same concentrations of arbutin and kojic acid and a 1% (because of its cytotoxicity) dose of hydroquinone. Sepiwhite's results were visible within seven days and the "efficacy greater and faster" than the competing ingredients. It is thought that the speed of its action is due to Sepiwhite's molecular structure, which is well adapted to reach the targeted melanocytes located in the lower layers of the epidermis.

It all sounds impressive, but I have yet to find an independent study.

The chemical name of Sepiwhite is undecylenoyl phenylalanine. You can buy a tub of it in its pure powder form from Making, should you feel inclined to whip up an anti-age spot cream in the kitchen. Pret-a-porter, it can be found in the following products:

DDF Discoloration Reversal Pods ($70 for 28 pods); Sothy's W Double Lightening Serum ($90); Skin White Bleaching Cream ($45.99) (which the company markets as "the Michael Jackson cream"); Arcona Mandarin Brightening Peel ($78/2oz)NutraLuxe High Potency Skin Whitening ($165).

See all FIVE BEST recommendations including Five Best for dark spots, Five Best for sagging skin, Five Best with vitamin C and Five Best eye creams

  • February 20, 2015

    by Michele Watson

    Thank you Marta! It seems to be gentle and effective. The range is called Dermafix and the product is Melanoderm. Their whole range has all the skin actives you teach us about and surprisingly affordable. Might be a good addition to your store...

  • February 7, 2015

    by Marta

    Hi Michele, it is an amino acid. I don't know about long term use, but I did find a study that concluded that side effects were negligable:

  • February 7, 2015

    by Michele Watson

    Hi Marta do you have any updates on the ingredient? Not much on Net. I am trying a product called Melanoderm with it in (by Dermafix). I wanted to use TIA as objective info on it - it contains Sepiwhite.
    Just wondering re safety in bloodstream as am using all over my legs and arms! It seems effective but am worried re reordering if this not safe. I wrote in and the ditsributer says its from amino acid...

  • July 23, 2014

    by yetunde

    Ill love to buy some sepiwhite creams! Can it be shipped to Nigeria! How m any days is the delivery?

  • January 26, 2012

    by Jennifer

    I have to agree with the posts regarding F&F., in the beginning it would work but the consistency of it was not as good. Same thing about the customer service being bad is true and they are so expensive for small quantity. I've officially given up on F&F. Just searching for a new alternative. Tonique products I've tried, but it doesn't work as fast as F&F, but customer service is great and their soap smells so good. I think if Tonique increases a main ingredient it will get my business back.. No more F&F for me

  • February 2, 2010

    by Amy

    I have placed several orders with fair and flawless for a period of one year. However like noted by someone they lack consistency because sometimes they work and sometimes they do not. I continue ordering from them because at the time they were the only non hydroquine product that I know of. When ever I called to inquire about my order or why a particular product did not work this time around, I always get very very rude customer service. I always spoke to the same lady and she is always rude and will hang up the phone on me on several occassion. Since now I know of Tonique I wll never ordr from fair and flawless again.

  • December 23, 2009

    by Rania

    Ignore anything that comes out of Nikkicute's mouth, she is the infamous seller, marketer, and advertiser for Fair & Flawless. She insults others do not agree with her and who dares to speak of anyother products that contains sepiwhite other than F&F...she will bite your head off. It can easily be researched through a google search and "cache" additional info and see how she bites peoples heads off.

    Some of F&F's products can work, although they lack consistency in their formulations so you may end up w/ a jar that's ineffective, very poor and rude customer service, and have given some customers serious 1st and 2nd degree burns when the formulation is poorly handled.

    Speak with real and genuine buyers who have purchased products contains sepiwhite, this is really good stuff that can lighten and even the skin tone safely.

  • November 23, 2009

    by Raynay

    I highly recommend Sepiwhite products from Fair and Flawless. The Sepiwhite in their products have been proven safe, effective and most of all authentic!! Please be aware of rouge sellers who are trying to capitalize on Fair and Flawless success by duplicating their likeness in naming products and website presentation. DON'T BE FOOLED!! Get the REAL thing!!

  • October 7, 2009

    by beautilgirl

    fair and flawless is a total scam.I will never use them again or recommend them to anyone.

  • September 28, 2009

    by Michelle

    I cannot speak for the others here but, I use Tonique it also contains sepiwhite and it is the only skin whitener that keeps my skin light and evenly toned. I highly recommend their products.

  • July 12, 2009

    by Golden Goddess

    ...are you guys sellers or are you actual buyers? I heard sepiwhite is very good, but I want to make sure I buy a brand product that actually works from real buyers and not sellers..

  • May 14, 2009

    by Charlene

    I used Tonique to fade my age spots it worked well. After using the cream I saw results within 5 days.

  • March 12, 2009

    by Nikki

    Yes, that is where I have first heard and
    tried my first sepiwhite cream was from
    the Fair and Flawless company.
    The Facial Whitener cream worked great
    on my complexion, you know a product is
    working when others notice.

    I have always wanted to try the lightening
    5x gel because I heard it was a very
    strong lightener and I need something
    strong to lighten the skin on my body.

  • January 30, 2009

    by Rosetta

    I have used a skin lightening gel containing sepiwhite from
    and the results were amazing. Sepiwhite does work better than hydroquinone,kojic acid and arbutin.

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